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Gene: HDHD3 |
Gene summary for HDHD3 |
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Gene information | Species | Human | Gene symbol | HDHD3 | Gene ID | 81932 |
Gene name | haloacid dehalogenase like hydrolase domain containing 3 | |
Gene Alias | 2810435D12Rik | |
Cytomap | 9q32 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BSH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81932 | HDHD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.36e-09 | 6.80e-01 | -0.1808 |
81932 | HDHD3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.78e-08 | 6.04e-01 | -0.0811 |
81932 | HDHD3 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.30e-04 | 5.28e-01 | -0.1088 |
81932 | HDHD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.43e-21 | 7.12e-01 | -0.1954 |
81932 | HDHD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.67e-07 | 1.30e+00 | -0.2602 |
81932 | HDHD3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.01e-02 | 5.19e-01 | -0.1207 |
81932 | HDHD3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.77e-07 | 6.95e-01 | -0.1526 |
81932 | HDHD3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.35e-16 | 7.56e-01 | -0.1464 |
81932 | HDHD3 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.13e-05 | 4.94e-01 | -0.1001 |
81932 | HDHD3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.04e-16 | 8.30e-01 | -0.059 |
81932 | HDHD3 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.74e-09 | 8.02e-01 | -0.0842 |
81932 | HDHD3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.94e-03 | 2.64e-01 | 0.096 |
81932 | HDHD3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.39e-02 | 4.71e-01 | -0.0177 |
81932 | HDHD3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.78e-05 | 5.72e-01 | 0.281 |
81932 | HDHD3 | A002-C-010 | Human | Colorectum | FAP | 3.12e-02 | -1.38e-01 | 0.242 |
81932 | HDHD3 | A001-C-207 | Human | Colorectum | FAP | 2.24e-03 | -2.77e-01 | 0.1278 |
81932 | HDHD3 | A015-C-203 | Human | Colorectum | FAP | 1.26e-11 | -1.24e-01 | -0.1294 |
81932 | HDHD3 | A015-C-204 | Human | Colorectum | FAP | 8.86e-04 | -2.45e-01 | -0.0228 |
81932 | HDHD3 | A002-C-201 | Human | Colorectum | FAP | 2.68e-06 | -2.26e-01 | 0.0324 |
81932 | HDHD3 | A002-C-203 | Human | Colorectum | FAP | 5.83e-03 | -1.30e-01 | 0.2786 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDHD3 | SNV | Missense_Mutation | novel | c.226N>A | p.Leu76Met | p.L76M | Q9BSH5 | protein_coding | tolerated(0.16) | benign(0.073) | TCGA-AR-A0TV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | c.352N>A | p.Glu118Lys | p.E118K | Q9BSH5 | protein_coding | tolerated(0.84) | benign(0.01) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD | |
HDHD3 | SNV | Missense_Mutation | novel | c.331N>C | p.Trp111Arg | p.W111R | Q9BSH5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs772718812 | c.23N>A | p.Arg8Gln | p.R8Q | Q9BSH5 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs528728306 | c.416G>A | p.Arg139Gln | p.R139Q | Q9BSH5 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-D5-6924-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | rs148070774 | c.65N>A | p.Arg22His | p.R22H | Q9BSH5 | protein_coding | deleterious(0.02) | benign(0.075) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.308N>C | p.Lys103Thr | p.K103T | Q9BSH5 | protein_coding | tolerated(0.13) | benign(0.055) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.155N>T | p.Ala52Val | p.A52V | Q9BSH5 | protein_coding | tolerated(0.29) | benign(0.069) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.394G>A | p.Ala132Thr | p.A132T | Q9BSH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-AX-A3G8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HDHD3 | SNV | Missense_Mutation | novel | c.641C>T | p.Pro214Leu | p.P214L | Q9BSH5 | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CC-A5UD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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