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Gene: GRAMD3 |
Gene summary for GRAMD3 |
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Gene information | Species | Human | Gene symbol | GRAMD3 | Gene ID | 65983 |
Gene name | GRAM domain containing 2B | |
Gene Alias | GRAMD3 | |
Cytomap | 5q23.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96HH9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65983 | GRAMD3 | P1T-E | Human | Esophagus | ESCC | 1.17e-02 | 9.13e-01 | 0.0875 |
65983 | GRAMD3 | P2T-E | Human | Esophagus | ESCC | 1.76e-19 | 4.17e-01 | 0.1177 |
65983 | GRAMD3 | P4T-E | Human | Esophagus | ESCC | 1.02e-08 | 1.35e-01 | 0.1323 |
65983 | GRAMD3 | P5T-E | Human | Esophagus | ESCC | 5.80e-05 | -3.59e-02 | 0.1327 |
65983 | GRAMD3 | P8T-E | Human | Esophagus | ESCC | 1.27e-31 | 9.57e-01 | 0.0889 |
65983 | GRAMD3 | P9T-E | Human | Esophagus | ESCC | 3.56e-03 | 4.97e-02 | 0.1131 |
65983 | GRAMD3 | P10T-E | Human | Esophagus | ESCC | 2.53e-08 | -2.41e-02 | 0.116 |
65983 | GRAMD3 | P11T-E | Human | Esophagus | ESCC | 3.80e-12 | 5.65e-01 | 0.1426 |
65983 | GRAMD3 | P12T-E | Human | Esophagus | ESCC | 1.90e-09 | 2.03e-01 | 0.1122 |
65983 | GRAMD3 | P15T-E | Human | Esophagus | ESCC | 1.17e-04 | 2.32e-01 | 0.1149 |
65983 | GRAMD3 | P16T-E | Human | Esophagus | ESCC | 1.26e-15 | 3.22e-01 | 0.1153 |
65983 | GRAMD3 | P19T-E | Human | Esophagus | ESCC | 5.38e-10 | 6.48e-01 | 0.1662 |
65983 | GRAMD3 | P20T-E | Human | Esophagus | ESCC | 1.23e-06 | 8.28e-02 | 0.1124 |
65983 | GRAMD3 | P21T-E | Human | Esophagus | ESCC | 2.75e-03 | 2.39e-01 | 0.1617 |
65983 | GRAMD3 | P23T-E | Human | Esophagus | ESCC | 1.82e-29 | 1.71e+00 | 0.108 |
65983 | GRAMD3 | P24T-E | Human | Esophagus | ESCC | 6.12e-04 | 8.51e-02 | 0.1287 |
65983 | GRAMD3 | P26T-E | Human | Esophagus | ESCC | 2.89e-08 | 1.35e-01 | 0.1276 |
65983 | GRAMD3 | P27T-E | Human | Esophagus | ESCC | 8.42e-16 | 3.01e-01 | 0.1055 |
65983 | GRAMD3 | P31T-E | Human | Esophagus | ESCC | 4.28e-03 | 1.64e-02 | 0.1251 |
65983 | GRAMD3 | P32T-E | Human | Esophagus | ESCC | 6.68e-06 | 1.54e-02 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRAMD3 | SNV | Missense_Mutation | novel | c.1057N>G | p.Gln353Glu | p.Q353E | Q96HH9 | protein_coding | tolerated(0.38) | benign(0.006) | TCGA-AQ-A7U7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Targeted Molecular therapy | rituximab | CR |
GRAMD3 | SNV | Missense_Mutation | novel | c.1102G>C | p.Val368Leu | p.V368L | Q96HH9 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BH-A5IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
GRAMD3 | insertion | Frame_Shift_Ins | novel | c.177_178insTGCCATCTTAACATGTCTTTCTTTAGGCTCAGTCTCCATGGAGT | p.Pro60CysfsTer49 | p.P60Cfs*49 | Q96HH9 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
GRAMD3 | SNV | Missense_Mutation | c.331N>A | p.Glu111Lys | p.E111K | Q96HH9 | protein_coding | deleterious(0) | benign(0.09) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GRAMD3 | insertion | Frame_Shift_Ins | novel | c.1003_1004insT | p.Val337CysfsTer13 | p.V337Cfs*13 | Q96HH9 | protein_coding | TCGA-Q1-A73Q-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
GRAMD3 | SNV | Missense_Mutation | novel | c.530N>C | p.Lys177Thr | p.K177T | Q96HH9 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GRAMD3 | SNV | Missense_Mutation | c.1333A>G | p.Asn445Asp | p.N445D | Q96HH9 | protein_coding | tolerated(0.74) | benign(0.001) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRAMD3 | SNV | Missense_Mutation | c.1305N>G | p.Ile435Met | p.I435M | Q96HH9 | protein_coding | deleterious(0) | possibly_damaging(0.621) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
GRAMD3 | SNV | Missense_Mutation | c.1004T>G | p.Leu335Arg | p.L335R | Q96HH9 | protein_coding | tolerated(0.21) | benign(0.368) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GRAMD3 | SNV | Missense_Mutation | rs780081964 | c.592N>T | p.Pro198Ser | p.P198S | Q96HH9 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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