![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: GDAP2 |
Gene summary for GDAP2 |
![]() |
Gene information | Species | Human | Gene symbol | GDAP2 | Gene ID | 54834 |
Gene name | ganglioside induced differentiation associated protein 2 | |
Gene Alias | MACROD3 | |
Cytomap | 1p12 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q9NXN4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54834 | GDAP2 | LZE4T | Human | Esophagus | ESCC | 8.80e-11 | 2.93e-01 | 0.0811 |
54834 | GDAP2 | LZE7T | Human | Esophagus | ESCC | 3.91e-03 | 2.07e-01 | 0.0667 |
54834 | GDAP2 | LZE20T | Human | Esophagus | ESCC | 7.69e-04 | 1.94e-01 | 0.0662 |
54834 | GDAP2 | LZE24T | Human | Esophagus | ESCC | 1.78e-07 | 2.48e-01 | 0.0596 |
54834 | GDAP2 | P1T-E | Human | Esophagus | ESCC | 3.11e-04 | 1.79e-01 | 0.0875 |
54834 | GDAP2 | P2T-E | Human | Esophagus | ESCC | 3.97e-15 | 2.69e-01 | 0.1177 |
54834 | GDAP2 | P4T-E | Human | Esophagus | ESCC | 8.16e-14 | 3.62e-01 | 0.1323 |
54834 | GDAP2 | P5T-E | Human | Esophagus | ESCC | 4.50e-07 | 1.50e-01 | 0.1327 |
54834 | GDAP2 | P8T-E | Human | Esophagus | ESCC | 6.29e-19 | 2.34e-01 | 0.0889 |
54834 | GDAP2 | P9T-E | Human | Esophagus | ESCC | 1.06e-07 | 1.97e-01 | 0.1131 |
54834 | GDAP2 | P10T-E | Human | Esophagus | ESCC | 7.37e-18 | 2.35e-01 | 0.116 |
54834 | GDAP2 | P11T-E | Human | Esophagus | ESCC | 9.09e-07 | 2.27e-01 | 0.1426 |
54834 | GDAP2 | P12T-E | Human | Esophagus | ESCC | 3.77e-18 | 2.57e-01 | 0.1122 |
54834 | GDAP2 | P15T-E | Human | Esophagus | ESCC | 2.47e-08 | 1.84e-01 | 0.1149 |
54834 | GDAP2 | P16T-E | Human | Esophagus | ESCC | 2.86e-06 | 1.87e-01 | 0.1153 |
54834 | GDAP2 | P17T-E | Human | Esophagus | ESCC | 8.59e-03 | 1.33e-01 | 0.1278 |
54834 | GDAP2 | P19T-E | Human | Esophagus | ESCC | 4.82e-02 | 1.92e-01 | 0.1662 |
54834 | GDAP2 | P20T-E | Human | Esophagus | ESCC | 6.00e-13 | 2.49e-01 | 0.1124 |
54834 | GDAP2 | P21T-E | Human | Esophagus | ESCC | 7.23e-16 | 2.81e-01 | 0.1617 |
54834 | GDAP2 | P22T-E | Human | Esophagus | ESCC | 2.63e-10 | 1.32e-01 | 0.1236 |
Page: 1 2 3 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325261 | Esophagus | ESCC | response to retinoic acid | 63/8552 | 107/18723 | 4.05e-03 | 1.62e-02 | 63 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GDAP2 | SNV | Missense_Mutation | rs766549019 | c.559C>T | p.Arg187Cys | p.R187C | Q9NXN4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GDAP2 | SNV | Missense_Mutation | novel | c.1159N>A | p.Val387Ile | p.V387I | Q9NXN4 | protein_coding | tolerated(0.14) | probably_damaging(0.997) | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
GDAP2 | SNV | Missense_Mutation | novel | c.1111N>G | p.Leu371Val | p.L371V | Q9NXN4 | protein_coding | tolerated(0.17) | benign(0.306) | TCGA-D8-A145-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
GDAP2 | deletion | Frame_Shift_Del | novel | c.526delT | p.Tyr176IlefsTer3 | p.Y176Ifs*3 | Q9NXN4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GDAP2 | SNV | Missense_Mutation | novel | c.1082C>A | p.Pro361His | p.P361H | Q9NXN4 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GDAP2 | SNV | Missense_Mutation | novel | c.43A>G | p.Thr15Ala | p.T15A | Q9NXN4 | protein_coding | tolerated(0.16) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GDAP2 | SNV | Missense_Mutation | rs757285829 | c.91N>A | p.Asp31Asn | p.D31N | Q9NXN4 | protein_coding | tolerated(0.34) | benign(0.009) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR |
GDAP2 | SNV | Missense_Mutation | novel | c.76G>A | p.Glu26Lys | p.E26K | Q9NXN4 | protein_coding | tolerated(0.31) | benign(0.018) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GDAP2 | SNV | Missense_Mutation | novel | c.538N>A | p.Asp180Asn | p.D180N | Q9NXN4 | protein_coding | tolerated(0.15) | possibly_damaging(0.864) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
GDAP2 | SNV | Missense_Mutation | novel | c.593A>G | p.Glu198Gly | p.E198G | Q9NXN4 | protein_coding | tolerated(0.06) | benign(0.038) | TCGA-AA-3494-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PR |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |