Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048857 | Colorectum | AD | neural nucleus development | 27/3918 | 64/18723 | 9.57e-05 | 1.45e-03 | 27 |
GO:1901654 | Colorectum | AD | response to ketone | 59/3918 | 194/18723 | 1.14e-03 | 1.04e-02 | 59 |
GO:00488571 | Colorectum | SER | neural nucleus development | 26/2897 | 64/18723 | 1.09e-06 | 5.11e-05 | 26 |
GO:19016541 | Colorectum | SER | response to ketone | 44/2897 | 194/18723 | 5.01e-03 | 3.88e-02 | 44 |
GO:00488572 | Colorectum | MSS | neural nucleus development | 26/3467 | 64/18723 | 3.19e-05 | 6.30e-04 | 26 |
GO:19016542 | Colorectum | MSS | response to ketone | 58/3467 | 194/18723 | 7.70e-05 | 1.28e-03 | 58 |
GO:00488573 | Colorectum | MSI-H | neural nucleus development | 13/1319 | 64/18723 | 4.43e-04 | 9.50e-03 | 13 |
GO:19016543 | Colorectum | MSI-H | response to ketone | 26/1319 | 194/18723 | 1.17e-03 | 1.92e-02 | 26 |
GO:19016544 | Colorectum | FAP | response to ketone | 45/2622 | 194/18723 | 3.67e-04 | 4.63e-03 | 45 |
GO:00488574 | Colorectum | FAP | neural nucleus development | 19/2622 | 64/18723 | 8.94e-04 | 9.08e-03 | 19 |
GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
GO:0021543 | Colorectum | FAP | pallium development | 36/2622 | 169/18723 | 6.06e-03 | 3.81e-02 | 36 |
GO:0030900 | Colorectum | FAP | forebrain development | 70/2622 | 379/18723 | 8.64e-03 | 4.98e-02 | 70 |
GO:00309001 | Colorectum | CRC | forebrain development | 66/2078 | 379/18723 | 1.36e-04 | 2.57e-03 | 66 |
GO:00488575 | Colorectum | CRC | neural nucleus development | 17/2078 | 64/18723 | 4.59e-04 | 6.70e-03 | 17 |
GO:00219871 | Colorectum | CRC | cerebral cortex development | 24/2078 | 114/18723 | 1.45e-03 | 1.57e-02 | 24 |
GO:00215431 | Colorectum | CRC | pallium development | 32/2078 | 169/18723 | 1.74e-03 | 1.79e-02 | 32 |
GO:0021537 | Colorectum | CRC | telencephalon development | 43/2078 | 248/18723 | 2.01e-03 | 2.01e-02 | 43 |
GO:190165420 | Esophagus | HGIN | response to ketone | 48/2587 | 194/18723 | 3.17e-05 | 8.12e-04 | 48 |
GO:00335748 | Esophagus | HGIN | response to testosterone | 15/2587 | 42/18723 | 3.03e-04 | 5.13e-03 | 15 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FOXP2 | SNV | Missense_Mutation | novel | c.2042G>T | p.Gly681Val | p.G681V | O15409 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FOXP2 | SNV | Missense_Mutation | rs760842249 | c.113N>A | p.Gly38Asp | p.G38D | O15409 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.997) | TCGA-AO-A03V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
FOXP2 | SNV | Missense_Mutation | | c.2122G>A | p.Glu708Lys | p.E708K | O15409 | protein_coding | deleterious(0.02) | benign(0.217) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
FOXP2 | SNV | Missense_Mutation | | c.86N>A | p.Ala29Asp | p.A29D | O15409 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.997) | TCGA-E2-A1IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
FOXP2 | SNV | Missense_Mutation | novel | c.1280T>C | p.Leu427Pro | p.L427P | O15409 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | | SD |
FOXP2 | insertion | Nonsense_Mutation | novel | c.1839_1840insCCCTTTAGTTAATAATAAATTCTATTTT | p.Thr614ProfsTer4 | p.T614Pfs*4 | O15409 | protein_coding | | | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
FOXP2 | insertion | Frame_Shift_Ins | novel | c.2005_2006insGAAGAAGCAAGAAGGACACCCTGTGGCAAAATCTGGA | p.Asp669GlyfsTer22 | p.D669Gfs*22 | O15409 | protein_coding | | | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
FOXP2 | insertion | Nonsense_Mutation | novel | c.154_155insATTAGTGATATTCTTGATAGATTTTATTTCCAGCTTTCATATCT | p.Leu52HisfsTer2 | p.L52Hfs*2 | O15409 | protein_coding | | | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
FOXP2 | insertion | Nonsense_Mutation | novel | c.1814_1815insGTTAATAATAAATT | p.Tyr605Ter | p.Y605* | O15409 | protein_coding | | | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
FOXP2 | insertion | Nonsense_Mutation | novel | c.1815_1816insTATTTTATCAGTTTGTGATTG | p.Tyr605_Gln606insTyrPheIleSerLeuTerLeu | p.Y605_Q606insYFISL*L | O15409 | protein_coding | | | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |