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Gene: FAM60A |
Gene summary for FAM60A |
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Gene information | Species | Human | Gene symbol | FAM60A | Gene ID | 58516 |
Gene name | SIN3-HDAC complex associated factor | |
Gene Alias | C12orf14 | |
Cytomap | 12p11.21 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q9NP50 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
58516 | FAM60A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.19e-18 | 2.96e-01 | 0.294 |
58516 | FAM60A | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.42e-04 | 8.07e-01 | 0.3487 |
58516 | FAM60A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.31e-25 | 6.23e-01 | 0.281 |
58516 | FAM60A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.93e-21 | 4.82e-01 | 0.3859 |
58516 | FAM60A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.57e-07 | 3.09e-01 | 0.2585 |
58516 | FAM60A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.56e-16 | 3.54e-01 | 0.3005 |
58516 | FAM60A | P1T-E | Human | Esophagus | ESCC | 1.34e-15 | 1.03e+00 | 0.0875 |
58516 | FAM60A | P2T-E | Human | Esophagus | ESCC | 1.23e-117 | 2.16e+00 | 0.1177 |
58516 | FAM60A | P4T-E | Human | Esophagus | ESCC | 4.74e-53 | 1.52e+00 | 0.1323 |
58516 | FAM60A | P5T-E | Human | Esophagus | ESCC | 2.37e-32 | 8.77e-01 | 0.1327 |
58516 | FAM60A | P8T-E | Human | Esophagus | ESCC | 1.65e-60 | 1.36e+00 | 0.0889 |
58516 | FAM60A | P9T-E | Human | Esophagus | ESCC | 1.68e-22 | 6.23e-01 | 0.1131 |
58516 | FAM60A | P10T-E | Human | Esophagus | ESCC | 3.60e-75 | 1.49e+00 | 0.116 |
58516 | FAM60A | P11T-E | Human | Esophagus | ESCC | 4.50e-05 | 4.14e-01 | 0.1426 |
58516 | FAM60A | P12T-E | Human | Esophagus | ESCC | 2.81e-72 | 1.54e+00 | 0.1122 |
58516 | FAM60A | P15T-E | Human | Esophagus | ESCC | 7.53e-47 | 1.30e+00 | 0.1149 |
58516 | FAM60A | P16T-E | Human | Esophagus | ESCC | 4.42e-104 | 2.07e+00 | 0.1153 |
58516 | FAM60A | P17T-E | Human | Esophagus | ESCC | 2.46e-17 | 1.09e+00 | 0.1278 |
58516 | FAM60A | P19T-E | Human | Esophagus | ESCC | 3.82e-03 | 7.68e-01 | 0.1662 |
58516 | FAM60A | P20T-E | Human | Esophagus | ESCC | 2.22e-36 | 1.09e+00 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM60A | SNV | Missense_Mutation | c.32N>A | p.Arg11Gln | p.R11Q | Q9NP50 | protein_coding | tolerated(0.08) | probably_damaging(0.979) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
FAM60A | SNV | Missense_Mutation | c.149G>A | p.Gly50Glu | p.G50E | Q9NP50 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM60A | SNV | Missense_Mutation | c.487N>T | p.Asp163Tyr | p.D163Y | Q9NP50 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FAM60A | SNV | Missense_Mutation | c.340N>A | p.Glu114Lys | p.E114K | Q9NP50 | protein_coding | tolerated(0.19) | benign(0.007) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FAM60A | SNV | Missense_Mutation | novel | c.312N>C | p.Lys104Asn | p.K104N | Q9NP50 | protein_coding | tolerated(0.06) | benign(0.154) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
FAM60A | SNV | Missense_Mutation | c.97C>T | p.Arg33Cys | p.R33C | Q9NP50 | protein_coding | tolerated(0.06) | probably_damaging(0.994) | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM60A | SNV | Missense_Mutation | novel | c.212A>C | p.Lys71Thr | p.K71T | Q9NP50 | protein_coding | tolerated(0.16) | benign(0.163) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
FAM60A | SNV | Missense_Mutation | novel | c.401C>T | p.Ser134Phe | p.S134F | Q9NP50 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FAM60A | SNV | Missense_Mutation | c.32G>A | p.Arg11Gln | p.R11Q | Q9NP50 | protein_coding | tolerated(0.08) | probably_damaging(0.979) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
FAM60A | SNV | Missense_Mutation | novel | c.638C>A | p.Pro213His | p.P213H | Q9NP50 | protein_coding | deleterious_low_confidence(0.01) | benign(0.04) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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