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Gene: FAM58A |
Gene summary for FAM58A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM58A | Gene ID | 92002 |
Gene name | cyclin Q | |
Gene Alias | CycM | |
Cytomap | Xq28 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8N1B3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
92002 | FAM58A | P1T-E | Human | Esophagus | ESCC | 3.61e-10 | 4.62e-01 | 0.0875 |
92002 | FAM58A | P2T-E | Human | Esophagus | ESCC | 1.28e-40 | 7.58e-01 | 0.1177 |
92002 | FAM58A | P4T-E | Human | Esophagus | ESCC | 4.23e-26 | 6.40e-01 | 0.1323 |
92002 | FAM58A | P5T-E | Human | Esophagus | ESCC | 1.85e-27 | 5.27e-01 | 0.1327 |
92002 | FAM58A | P8T-E | Human | Esophagus | ESCC | 2.42e-09 | 1.76e-01 | 0.0889 |
92002 | FAM58A | P9T-E | Human | Esophagus | ESCC | 1.29e-23 | 5.45e-01 | 0.1131 |
92002 | FAM58A | P10T-E | Human | Esophagus | ESCC | 1.30e-40 | 7.54e-01 | 0.116 |
92002 | FAM58A | P11T-E | Human | Esophagus | ESCC | 3.00e-05 | 2.61e-01 | 0.1426 |
92002 | FAM58A | P12T-E | Human | Esophagus | ESCC | 8.49e-16 | 3.60e-01 | 0.1122 |
92002 | FAM58A | P15T-E | Human | Esophagus | ESCC | 2.38e-07 | 2.14e-01 | 0.1149 |
92002 | FAM58A | P16T-E | Human | Esophagus | ESCC | 2.20e-11 | 2.02e-01 | 0.1153 |
92002 | FAM58A | P19T-E | Human | Esophagus | ESCC | 6.36e-04 | 5.13e-01 | 0.1662 |
92002 | FAM58A | P20T-E | Human | Esophagus | ESCC | 6.92e-13 | 2.00e-01 | 0.1124 |
92002 | FAM58A | P21T-E | Human | Esophagus | ESCC | 1.09e-30 | 5.66e-01 | 0.1617 |
92002 | FAM58A | P22T-E | Human | Esophagus | ESCC | 2.72e-62 | 9.88e-01 | 0.1236 |
92002 | FAM58A | P23T-E | Human | Esophagus | ESCC | 4.18e-43 | 1.02e+00 | 0.108 |
92002 | FAM58A | P24T-E | Human | Esophagus | ESCC | 5.21e-19 | 4.11e-01 | 0.1287 |
92002 | FAM58A | P26T-E | Human | Esophagus | ESCC | 5.09e-21 | 4.54e-01 | 0.1276 |
92002 | FAM58A | P27T-E | Human | Esophagus | ESCC | 3.55e-05 | 1.54e-01 | 0.1055 |
92002 | FAM58A | P28T-E | Human | Esophagus | ESCC | 5.15e-38 | 7.43e-01 | 0.1149 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM58A | SNV | Missense_Mutation | novel | c.473N>A | p.Arg158His | p.R158H | Q8N1B3 | protein_coding | tolerated(0.15) | possibly_damaging(0.809) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | novel | c.223N>C | p.Ser75Pro | p.S75P | Q8N1B3 | protein_coding | deleterious(0.04) | possibly_damaging(0.738) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | c.563N>T | p.Ala188Val | p.A188V | Q8N1B3 | protein_coding | deleterious(0.01) | benign(0.311) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | novel | c.196G>A | p.Ala66Thr | p.A66T | Q8N1B3 | protein_coding | tolerated(0.58) | benign(0.011) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FAM58A | SNV | Missense_Mutation | c.508N>A | p.Ala170Thr | p.A170T | Q8N1B3 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | c.364G>A | p.Val122Met | p.V122M | Q8N1B3 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | novel | c.646C>T | p.Pro216Ser | p.P216S | Q8N1B3 | protein_coding | tolerated(0.21) | benign(0.073) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | novel | c.436N>T | p.Leu146Phe | p.L146F | Q8N1B3 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
FAM58A | SNV | Missense_Mutation | c.508N>A | p.Ala170Thr | p.A170T | Q8N1B3 | protein_coding | deleterious(0) | possibly_damaging(0.841) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM58A | SNV | Missense_Mutation | novel | c.433N>A | p.Leu145Met | p.L145M | Q8N1B3 | protein_coding | tolerated(0.21) | probably_damaging(0.991) | TCGA-AX-A3FT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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