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Gene: FAM174A |
Gene summary for FAM174A |
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Gene information | Species | Human | Gene symbol | FAM174A | Gene ID | 345757 |
Gene name | family with sequence similarity 174 member A | |
Gene Alias | HGS_RE408 | |
Cytomap | 5q21.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8TBP5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
345757 | FAM174A | LZE3D | Human | Esophagus | HGIN | 1.81e-02 | 5.40e-01 | 0.0668 |
345757 | FAM174A | LZE4T | Human | Esophagus | ESCC | 1.25e-13 | 2.07e-01 | 0.0811 |
345757 | FAM174A | LZE7T | Human | Esophagus | ESCC | 1.50e-10 | 2.45e-01 | 0.0667 |
345757 | FAM174A | LZE8T | Human | Esophagus | ESCC | 5.07e-11 | 3.51e-01 | 0.067 |
345757 | FAM174A | LZE20T | Human | Esophagus | ESCC | 3.14e-10 | 1.12e-01 | 0.0662 |
345757 | FAM174A | LZE24T | Human | Esophagus | ESCC | 6.91e-15 | 6.32e-01 | 0.0596 |
345757 | FAM174A | LZE6T | Human | Esophagus | ESCC | 8.96e-07 | 2.59e-01 | 0.0845 |
345757 | FAM174A | P1T-E | Human | Esophagus | ESCC | 2.05e-11 | 6.75e-01 | 0.0875 |
345757 | FAM174A | P2T-E | Human | Esophagus | ESCC | 4.10e-28 | 3.78e-01 | 0.1177 |
345757 | FAM174A | P4T-E | Human | Esophagus | ESCC | 1.02e-19 | 4.77e-01 | 0.1323 |
345757 | FAM174A | P5T-E | Human | Esophagus | ESCC | 1.10e-08 | 1.26e-01 | 0.1327 |
345757 | FAM174A | P8T-E | Human | Esophagus | ESCC | 1.27e-32 | 5.29e-01 | 0.0889 |
345757 | FAM174A | P9T-E | Human | Esophagus | ESCC | 3.13e-11 | 2.81e-01 | 0.1131 |
345757 | FAM174A | P10T-E | Human | Esophagus | ESCC | 6.63e-20 | 2.04e-01 | 0.116 |
345757 | FAM174A | P11T-E | Human | Esophagus | ESCC | 1.40e-21 | 6.98e-01 | 0.1426 |
345757 | FAM174A | P12T-E | Human | Esophagus | ESCC | 2.15e-30 | 4.88e-01 | 0.1122 |
345757 | FAM174A | P15T-E | Human | Esophagus | ESCC | 3.55e-12 | 2.43e-01 | 0.1149 |
345757 | FAM174A | P16T-E | Human | Esophagus | ESCC | 3.67e-11 | 1.37e-02 | 0.1153 |
345757 | FAM174A | P17T-E | Human | Esophagus | ESCC | 8.51e-17 | 5.99e-01 | 0.1278 |
345757 | FAM174A | P19T-E | Human | Esophagus | ESCC | 1.22e-03 | 8.42e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM174A | SNV | Missense_Mutation | rs779059148 | c.443N>A | p.Arg148Lys | p.R148K | Q8TBP5 | protein_coding | tolerated(0.26) | probably_damaging(0.992) | TCGA-AO-A0JC-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | SD |
FAM174A | SNV | Missense_Mutation | c.238G>C | p.Glu80Gln | p.E80Q | Q8TBP5 | protein_coding | tolerated(0.1) | possibly_damaging(0.881) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
FAM174A | insertion | Frame_Shift_Ins | novel | c.211_212insCA | p.Glu72LeufsTer41 | p.E72Lfs*41 | Q8TBP5 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
FAM174A | insertion | In_Frame_Ins | novel | c.213_214insCTTCTAATCTCAACTCCTCTAAAAGAAAAAAAG | p.Ala71_Glu72insLeuLeuIleSerThrProLeuLysGluLysLys | p.A71_E72insLLISTPLKEKK | Q8TBP5 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
FAM174A | SNV | Missense_Mutation | c.238N>A | p.Glu80Lys | p.E80K | Q8TBP5 | protein_coding | tolerated(0.1) | possibly_damaging(0.473) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
FAM174A | SNV | Missense_Mutation | c.238N>A | p.Glu80Lys | p.E80K | Q8TBP5 | protein_coding | tolerated(0.1) | possibly_damaging(0.473) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM174A | SNV | Missense_Mutation | c.464N>T | p.Arg155Ile | p.R155I | Q8TBP5 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FAM174A | SNV | Missense_Mutation | c.155C>T | p.Thr52Ile | p.T52I | Q8TBP5 | protein_coding | deleterious_low_confidence(0.02) | benign(0.261) | TCGA-AZ-6605-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folfox | SD | |
FAM174A | SNV | Missense_Mutation | c.553N>T | p.Ala185Ser | p.A185S | Q8TBP5 | protein_coding | deleterious(0.02) | possibly_damaging(0.559) | TCGA-D5-6537-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD | |
FAM174A | SNV | Missense_Mutation | c.266N>T | p.Ala89Val | p.A89V | Q8TBP5 | protein_coding | tolerated(0.32) | benign(0.049) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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