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Gene: FAM129B |
Gene summary for FAM129B |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM129B | Gene ID | 64855 |
Gene name | niban apoptosis regulator 2 | |
Gene Alias | C9orf88 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R872 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64855 | FAM129B | HTA11_3410_2000001011 | Human | Colorectum | AD | 6.18e-16 | -3.90e-01 | 0.0155 |
64855 | FAM129B | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.85e-09 | -3.90e-01 | -0.1808 |
64855 | FAM129B | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.06e-06 | -3.90e-01 | -0.0811 |
64855 | FAM129B | HTA11_78_2000001011 | Human | Colorectum | AD | 1.03e-10 | -3.90e-01 | -0.1088 |
64855 | FAM129B | HTA11_347_2000001011 | Human | Colorectum | AD | 3.32e-17 | -3.90e-01 | -0.1954 |
64855 | FAM129B | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.02e-06 | -3.90e-01 | -0.1207 |
64855 | FAM129B | HTA11_83_2000001011 | Human | Colorectum | SER | 4.39e-05 | -3.90e-01 | -0.1526 |
64855 | FAM129B | HTA11_696_2000001011 | Human | Colorectum | AD | 3.31e-19 | -3.90e-01 | -0.1464 |
64855 | FAM129B | HTA11_866_2000001011 | Human | Colorectum | AD | 4.78e-17 | -3.90e-01 | -0.1001 |
64855 | FAM129B | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.15e-12 | -3.90e-01 | -0.059 |
64855 | FAM129B | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.96e-02 | -3.90e-01 | -0.2061 |
64855 | FAM129B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.46e-04 | -3.90e-01 | -0.0842 |
64855 | FAM129B | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.34e-03 | -3.90e-01 | -0.0179 |
64855 | FAM129B | HTA11_866_3004761011 | Human | Colorectum | AD | 6.48e-14 | -3.90e-01 | 0.096 |
64855 | FAM129B | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.67e-02 | -3.90e-01 | 0.0528 |
64855 | FAM129B | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.91e-03 | -3.90e-01 | -0.0177 |
64855 | FAM129B | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.48e-08 | -3.90e-01 | 0.0338 |
64855 | FAM129B | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.78e-17 | -3.90e-01 | 0.0674 |
64855 | FAM129B | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.30e-03 | -3.90e-01 | 0.0112 |
64855 | FAM129B | HTA11_6818_2000001021 | Human | Colorectum | AD | 4.99e-06 | -3.90e-01 | 0.0588 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM129B | SNV | Missense_Mutation | c.1460N>A | p.Val487Glu | p.V487E | Q96TA1 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
FAM129B | SNV | Missense_Mutation | rs769941762 | c.202C>T | p.Arg68Cys | p.R68C | Q96TA1 | protein_coding | deleterious(0.03) | benign(0.031) | TCGA-BH-A0HI-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
FAM129B | SNV | Missense_Mutation | c.445G>A | p.Ala149Thr | p.A149T | Q96TA1 | protein_coding | tolerated(0.57) | benign(0.003) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FAM129B | SNV | Missense_Mutation | novel | c.1481A>G | p.Glu494Gly | p.E494G | Q96TA1 | protein_coding | deleterious(0.01) | possibly_damaging(0.663) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM129B | SNV | Missense_Mutation | rs749442375 | c.1333N>A | p.Val445Met | p.V445M | Q96TA1 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-UL-AAZ6-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | herceptin | SD |
FAM129B | SNV | Missense_Mutation | novel | c.641N>A | p.Arg214His | p.R214H | Q96TA1 | protein_coding | tolerated(0.08) | probably_damaging(0.975) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM129B | SNV | Missense_Mutation | novel | c.1769G>A | p.Gly590Asp | p.G590D | Q96TA1 | protein_coding | deleterious(0) | benign(0.241) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM129B | SNV | Missense_Mutation | c.73N>A | p.Leu25Met | p.L25M | Q96TA1 | protein_coding | tolerated(0.25) | benign(0.302) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FAM129B | SNV | Missense_Mutation | rs773683224 | c.134N>A | p.Arg45His | p.R45H | Q96TA1 | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FAM129B | SNV | Missense_Mutation | c.535N>A | p.Glu179Lys | p.E179K | Q96TA1 | protein_coding | tolerated(0.13) | probably_damaging(0.989) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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