![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: EFCAB14 |
Gene summary for EFCAB14 |
![]() |
Gene information | Species | Human | Gene symbol | EFCAB14 | Gene ID | 9813 |
Gene name | EF-hand calcium binding domain 14 | |
Gene Alias | KIAA0494 | |
Cytomap | 1p33 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | O75071 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9813 | EFCAB14 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.44e-02 | 3.05e-01 | -0.1088 |
9813 | EFCAB14 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-15 | 5.53e-01 | -0.1954 |
9813 | EFCAB14 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.00e-17 | 9.03e-01 | 0.294 |
9813 | EFCAB14 | A015-C-203 | Human | Colorectum | FAP | 6.33e-09 | -1.53e-01 | -0.1294 |
9813 | EFCAB14 | A001-C-108 | Human | Colorectum | FAP | 1.13e-04 | -1.60e-01 | -0.0272 |
9813 | EFCAB14 | A002-C-205 | Human | Colorectum | FAP | 1.54e-04 | -1.71e-01 | -0.1236 |
9813 | EFCAB14 | A015-C-006 | Human | Colorectum | FAP | 4.26e-03 | -2.51e-01 | -0.0994 |
9813 | EFCAB14 | A015-C-106 | Human | Colorectum | FAP | 4.75e-02 | -1.12e-01 | -0.0511 |
9813 | EFCAB14 | A002-C-114 | Human | Colorectum | FAP | 2.53e-03 | -1.93e-01 | -0.1561 |
9813 | EFCAB14 | A015-C-104 | Human | Colorectum | FAP | 1.07e-09 | -1.17e-01 | -0.1899 |
9813 | EFCAB14 | A001-C-014 | Human | Colorectum | FAP | 1.91e-02 | -1.48e-01 | 0.0135 |
9813 | EFCAB14 | A002-C-016 | Human | Colorectum | FAP | 2.04e-07 | -1.46e-01 | 0.0521 |
9813 | EFCAB14 | A002-C-116 | Human | Colorectum | FAP | 1.63e-11 | -1.42e-01 | -0.0452 |
9813 | EFCAB14 | A018-E-020 | Human | Colorectum | FAP | 4.61e-04 | -1.70e-01 | -0.2034 |
9813 | EFCAB14 | F034 | Human | Colorectum | FAP | 2.93e-08 | -1.80e-01 | -0.0665 |
9813 | EFCAB14 | F072B | Human | Colorectum | FAP | 2.02e-02 | -1.19e-01 | 0.257 |
9813 | EFCAB14 | CRC-1-8810 | Human | Colorectum | CRC | 1.42e-02 | 1.89e-01 | 0.6257 |
9813 | EFCAB14 | CRC-3-11773 | Human | Colorectum | CRC | 6.97e-03 | -1.37e-01 | 0.2564 |
9813 | EFCAB14 | LZE4T | Human | Esophagus | ESCC | 1.38e-09 | 1.79e-01 | 0.0811 |
9813 | EFCAB14 | LZE7T | Human | Esophagus | ESCC | 7.69e-05 | 2.42e-01 | 0.0667 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EFCAB14 | SNV | Missense_Mutation | c.1331N>T | p.Arg444Leu | p.R444L | O75071 | protein_coding | tolerated(0.45) | benign(0.001) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
EFCAB14 | SNV | Missense_Mutation | novel | c.1213N>G | p.Pro405Ala | p.P405A | O75071 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EFCAB14 | SNV | Missense_Mutation | c.116C>T | p.Ser39Leu | p.S39L | O75071 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
EFCAB14 | insertion | Frame_Shift_Ins | novel | c.1210_1211insTTTTTAGTAAAGAT | p.Lys404IlefsTer27 | p.K404Ifs*27 | O75071 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EFCAB14 | SNV | Missense_Mutation | rs148637456 | c.1435N>A | p.Asp479Asn | p.D479N | O75071 | protein_coding | tolerated(0.11) | benign(0.012) | TCGA-VS-A8EC-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
EFCAB14 | SNV | Missense_Mutation | c.987N>A | p.Met329Ile | p.M329I | O75071 | protein_coding | tolerated(0.16) | benign(0) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
EFCAB14 | SNV | Missense_Mutation | c.1016N>T | p.Arg339Ile | p.R339I | O75071 | protein_coding | tolerated(0.18) | possibly_damaging(0.549) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
EFCAB14 | SNV | Missense_Mutation | c.604T>G | p.Leu202Val | p.L202V | O75071 | protein_coding | tolerated(0.09) | benign(0.41) | TCGA-DM-A280-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EFCAB14 | SNV | Missense_Mutation | c.89N>A | p.Arg30His | p.R30H | O75071 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-F5-6813-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
EFCAB14 | SNV | Missense_Mutation | novel | c.1094N>T | p.Ser365Phe | p.S365F | O75071 | protein_coding | deleterious(0) | possibly_damaging(0.76) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |