|
Gene: DNAJC19 |
Gene summary for DNAJC19 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DNAJC19 | Gene ID | 131118 |
Gene name | DnaJ heat shock protein family (Hsp40) member C19 | |
Gene Alias | PAM18 | |
Cytomap | 3q26.33 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q96DA6 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
131118 | DNAJC19 | LZE2T | Human | Esophagus | ESCC | 2.38e-07 | 1.39e+00 | 0.082 |
131118 | DNAJC19 | LZE4T | Human | Esophagus | ESCC | 1.17e-16 | 6.55e-01 | 0.0811 |
131118 | DNAJC19 | LZE5T | Human | Esophagus | ESCC | 3.74e-03 | 6.68e-01 | 0.0514 |
131118 | DNAJC19 | LZE7T | Human | Esophagus | ESCC | 1.07e-12 | 1.05e+00 | 0.0667 |
131118 | DNAJC19 | LZE8T | Human | Esophagus | ESCC | 1.43e-03 | 4.21e-01 | 0.067 |
131118 | DNAJC19 | LZE20T | Human | Esophagus | ESCC | 4.37e-07 | 6.08e-01 | 0.0662 |
131118 | DNAJC19 | LZE22T | Human | Esophagus | ESCC | 4.54e-08 | 8.53e-01 | 0.068 |
131118 | DNAJC19 | LZE24T | Human | Esophagus | ESCC | 8.00e-30 | 9.87e-01 | 0.0596 |
131118 | DNAJC19 | LZE21T | Human | Esophagus | ESCC | 2.41e-08 | 1.12e+00 | 0.0655 |
131118 | DNAJC19 | LZE6T | Human | Esophagus | ESCC | 4.64e-08 | 8.00e-01 | 0.0845 |
131118 | DNAJC19 | P1T-E | Human | Esophagus | ESCC | 1.80e-14 | 1.11e+00 | 0.0875 |
131118 | DNAJC19 | P2T-E | Human | Esophagus | ESCC | 5.37e-82 | 1.75e+00 | 0.1177 |
131118 | DNAJC19 | P4T-E | Human | Esophagus | ESCC | 1.65e-69 | 2.33e+00 | 0.1323 |
131118 | DNAJC19 | P5T-E | Human | Esophagus | ESCC | 1.30e-84 | 1.87e+00 | 0.1327 |
131118 | DNAJC19 | P8T-E | Human | Esophagus | ESCC | 9.56e-75 | 1.32e+00 | 0.0889 |
131118 | DNAJC19 | P9T-E | Human | Esophagus | ESCC | 8.41e-52 | 1.35e+00 | 0.1131 |
131118 | DNAJC19 | P10T-E | Human | Esophagus | ESCC | 8.05e-95 | 1.83e+00 | 0.116 |
131118 | DNAJC19 | P11T-E | Human | Esophagus | ESCC | 1.47e-24 | 1.53e+00 | 0.1426 |
131118 | DNAJC19 | P12T-E | Human | Esophagus | ESCC | 8.11e-105 | 2.42e+00 | 0.1122 |
131118 | DNAJC19 | P15T-E | Human | Esophagus | ESCC | 8.78e-66 | 1.81e+00 | 0.1149 |
Page: 1 2 3 4 5 6 7 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | |
Oral cavity | LP | |
Oral cavity | EOLP | |
Oral cavity | NEOLP | |
Esophagus | HGIN |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0006839110 | Esophagus | ESCC | mitochondrial transport | 187/8552 | 254/18723 | 8.35e-20 | 9.81e-18 | 187 |
GO:0072655110 | Esophagus | ESCC | establishment of protein localization to mitochondrion | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:0070585110 | Esophagus | ESCC | protein localization to mitochondrion | 100/8552 | 125/18723 | 2.96e-15 | 1.77e-13 | 100 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:0006626110 | Esophagus | ESCC | protein targeting to mitochondrion | 81/8552 | 100/18723 | 3.60e-13 | 1.67e-11 | 81 |
GO:00718069 | Esophagus | ESCC | protein transmembrane transport | 47/8552 | 59/18723 | 9.02e-08 | 1.51e-06 | 47 |
GO:0061458110 | Esophagus | ESCC | reproductive system development | 247/8552 | 427/18723 | 2.24e-07 | 3.42e-06 | 247 |
GO:004860818 | Esophagus | ESCC | reproductive structure development | 245/8552 | 424/18723 | 2.82e-07 | 4.14e-06 | 245 |
GO:1990542110 | Esophagus | ESCC | mitochondrial transmembrane transport | 72/8552 | 102/18723 | 2.94e-07 | 4.23e-06 | 72 |
GO:00650026 | Esophagus | ESCC | intracellular protein transmembrane transport | 40/8552 | 51/18723 | 1.76e-06 | 2.08e-05 | 40 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:00447433 | Esophagus | ESCC | protein transmembrane import into intracellular organelle | 29/8552 | 36/18723 | 1.91e-05 | 1.67e-04 | 29 |
GO:00066505 | Esophagus | ESCC | glycerophospholipid metabolic process | 174/8552 | 306/18723 | 4.92e-05 | 3.85e-04 | 174 |
GO:00464864 | Esophagus | ESCC | glycerolipid metabolic process | 211/8552 | 392/18723 | 6.51e-04 | 3.46e-03 | 211 |
GO:00301503 | Esophagus | ESCC | protein import into mitochondrial matrix | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DNAJC19 | SNV | Missense_Mutation | novel | c.70N>A | p.Gln24Lys | p.Q24K | Q96DA6 | protein_coding | tolerated(0.21) | benign(0.06) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
DNAJC19 | SNV | Missense_Mutation | rs199774384 | c.251N>A | p.Arg84Gln | p.R84Q | Q96DA6 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DNAJC19 | SNV | Missense_Mutation | novel | c.220N>T | p.Asn74Tyr | p.N74Y | Q96DA6 | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
DNAJC19 | SNV | Missense_Mutation | c.119N>C | p.Leu40Pro | p.L40P | Q96DA6 | protein_coding | deleterious(0) | possibly_damaging(0.819) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DNAJC19 | SNV | Missense_Mutation | novel | c.301N>A | p.Ala101Thr | p.A101T | Q96DA6 | protein_coding | tolerated(0.53) | benign(0.072) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJC19 | SNV | Missense_Mutation | rs199774384 | c.251N>A | p.Arg84Gln | p.R84Q | Q96DA6 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
DNAJC19 | deletion | Frame_Shift_Del | c.348delN | p.Lys116AsnfsTer6 | p.K116Nfs*6 | Q96DA6 | protein_coding | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
DNAJC19 | SNV | Missense_Mutation | novel | c.198A>G | p.Ile66Met | p.I66M | Q96DA6 | protein_coding | deleterious(0) | possibly_damaging(0.715) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
DNAJC19 | SNV | Missense_Mutation | rs750384728 | c.58C>T | p.Arg20Cys | p.R20C | Q96DA6 | protein_coding | deleterious(0.01) | benign(0) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DNAJC19 | SNV | Missense_Mutation | rs199774384 | c.251G>A | p.Arg84Gln | p.R84Q | Q96DA6 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |