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Gene: DMAC2 |
Gene summary for DMAC2 |
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Gene information | Species | Human | Gene symbol | DMAC2 | Gene ID | 55101 |
Gene name | distal membrane arm assembly component 2 | |
Gene Alias | ATP5SL | |
Cytomap | 19q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NW81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55101 | DMAC2 | S014 | Human | Liver | HCC | 2.07e-29 | 7.42e-01 | 0.2254 |
55101 | DMAC2 | S015 | Human | Liver | HCC | 1.19e-42 | 1.20e+00 | 0.2375 |
55101 | DMAC2 | S016 | Human | Liver | HCC | 2.19e-28 | 6.28e-01 | 0.2243 |
55101 | DMAC2 | S027 | Human | Liver | HCC | 9.18e-07 | 4.39e-01 | 0.2446 |
55101 | DMAC2 | S028 | Human | Liver | HCC | 1.44e-13 | 4.04e-01 | 0.2503 |
55101 | DMAC2 | S029 | Human | Liver | HCC | 5.83e-19 | 5.05e-01 | 0.2581 |
55101 | DMAC2 | male-WTA | Human | Thyroid | PTC | 1.25e-05 | 1.06e-01 | 0.1037 |
55101 | DMAC2 | PTC01 | Human | Thyroid | PTC | 2.71e-09 | 1.70e-01 | 0.1899 |
55101 | DMAC2 | PTC03 | Human | Thyroid | PTC | 1.79e-02 | 1.72e-01 | 0.1784 |
55101 | DMAC2 | PTC04 | Human | Thyroid | PTC | 2.43e-03 | 1.40e-01 | 0.1927 |
55101 | DMAC2 | PTC05 | Human | Thyroid | PTC | 2.87e-07 | 2.90e-01 | 0.2065 |
55101 | DMAC2 | PTC06 | Human | Thyroid | PTC | 1.18e-11 | 2.71e-01 | 0.2057 |
55101 | DMAC2 | PTC07 | Human | Thyroid | PTC | 5.11e-12 | 2.68e-01 | 0.2044 |
55101 | DMAC2 | ATC09 | Human | Thyroid | ATC | 1.29e-03 | 1.75e-01 | 0.2871 |
55101 | DMAC2 | ATC11 | Human | Thyroid | ATC | 5.35e-04 | 3.68e-01 | 0.3386 |
55101 | DMAC2 | ATC12 | Human | Thyroid | ATC | 2.56e-04 | 1.42e-01 | 0.34 |
55101 | DMAC2 | ATC13 | Human | Thyroid | ATC | 5.07e-25 | 4.49e-01 | 0.34 |
55101 | DMAC2 | ATC1 | Human | Thyroid | ATC | 2.78e-04 | 2.04e-01 | 0.2878 |
55101 | DMAC2 | ATC2 | Human | Thyroid | ATC | 4.44e-15 | 9.53e-01 | 0.34 |
55101 | DMAC2 | ATC3 | Human | Thyroid | ATC | 6.30e-07 | 3.99e-01 | 0.338 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:1902600 | Colorectum | AD | proton transmembrane transport | 66/3918 | 157/18723 | 1.59e-09 | 1.17e-07 | 66 |
GO:0009144 | Colorectum | AD | purine nucleoside triphosphate metabolic process | 43/3918 | 88/18723 | 5.05e-09 | 3.19e-07 | 43 |
GO:0009205 | Colorectum | AD | purine ribonucleoside triphosphate metabolic process | 39/3918 | 82/18723 | 6.58e-08 | 3.40e-06 | 39 |
GO:0009141 | Colorectum | AD | nucleoside triphosphate metabolic process | 48/3918 | 112/18723 | 1.27e-07 | 6.02e-06 | 48 |
GO:0006754 | Colorectum | AD | ATP biosynthetic process | 30/3918 | 57/18723 | 1.27e-07 | 6.02e-06 | 30 |
GO:0009145 | Colorectum | AD | purine nucleoside triphosphate biosynthetic process | 34/3918 | 69/18723 | 1.54e-07 | 6.78e-06 | 34 |
GO:0009199 | Colorectum | AD | ribonucleoside triphosphate metabolic process | 40/3918 | 89/18723 | 3.04e-07 | 1.21e-05 | 40 |
GO:0009152 | Colorectum | AD | purine ribonucleotide biosynthetic process | 64/3918 | 169/18723 | 3.09e-07 | 1.22e-05 | 64 |
GO:0009206 | Colorectum | AD | purine ribonucleoside triphosphate biosynthetic process | 33/3918 | 68/18723 | 3.68e-07 | 1.43e-05 | 33 |
GO:0009201 | Colorectum | AD | ribonucleoside triphosphate biosynthetic process | 34/3918 | 74/18723 | 1.23e-06 | 4.01e-05 | 34 |
GO:0009260 | Colorectum | AD | ribonucleotide biosynthetic process | 66/3918 | 182/18723 | 1.25e-06 | 4.02e-05 | 66 |
GO:0009142 | Colorectum | AD | nucleoside triphosphate biosynthetic process | 37/3918 | 85/18723 | 2.16e-06 | 6.35e-05 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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