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Gene: CYB561D2 |
Gene summary for CYB561D2 |
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Gene information | Species | Human | Gene symbol | CYB561D2 | Gene ID | 11068 |
Gene name | cytochrome b561 family member D2 | |
Gene Alias | 101F6 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | A0A024R342 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11068 | CYB561D2 | LZE4T | Human | Esophagus | ESCC | 4.06e-02 | 7.71e-02 | 0.0811 |
11068 | CYB561D2 | LZE20T | Human | Esophagus | ESCC | 8.90e-07 | 1.53e-01 | 0.0662 |
11068 | CYB561D2 | LZE22T | Human | Esophagus | ESCC | 2.17e-02 | 1.89e-01 | 0.068 |
11068 | CYB561D2 | LZE24T | Human | Esophagus | ESCC | 2.93e-11 | 2.71e-01 | 0.0596 |
11068 | CYB561D2 | P1T-E | Human | Esophagus | ESCC | 1.57e-04 | 3.82e-01 | 0.0875 |
11068 | CYB561D2 | P2T-E | Human | Esophagus | ESCC | 8.23e-09 | 7.24e-02 | 0.1177 |
11068 | CYB561D2 | P4T-E | Human | Esophagus | ESCC | 1.52e-11 | 3.42e-01 | 0.1323 |
11068 | CYB561D2 | P5T-E | Human | Esophagus | ESCC | 1.44e-05 | 1.48e-01 | 0.1327 |
11068 | CYB561D2 | P8T-E | Human | Esophagus | ESCC | 3.21e-08 | 1.59e-01 | 0.0889 |
11068 | CYB561D2 | P9T-E | Human | Esophagus | ESCC | 1.17e-17 | 3.74e-01 | 0.1131 |
11068 | CYB561D2 | P10T-E | Human | Esophagus | ESCC | 1.75e-14 | 2.90e-01 | 0.116 |
11068 | CYB561D2 | P11T-E | Human | Esophagus | ESCC | 1.15e-08 | 2.75e-01 | 0.1426 |
11068 | CYB561D2 | P12T-E | Human | Esophagus | ESCC | 1.50e-07 | 1.61e-01 | 0.1122 |
11068 | CYB561D2 | P15T-E | Human | Esophagus | ESCC | 6.16e-13 | 1.81e-01 | 0.1149 |
11068 | CYB561D2 | P16T-E | Human | Esophagus | ESCC | 6.00e-11 | 1.50e-01 | 0.1153 |
11068 | CYB561D2 | P17T-E | Human | Esophagus | ESCC | 5.97e-09 | 2.67e-01 | 0.1278 |
11068 | CYB561D2 | P19T-E | Human | Esophagus | ESCC | 1.19e-04 | 5.12e-01 | 0.1662 |
11068 | CYB561D2 | P20T-E | Human | Esophagus | ESCC | 5.35e-05 | 1.51e-01 | 0.1124 |
11068 | CYB561D2 | P21T-E | Human | Esophagus | ESCC | 2.33e-36 | 5.85e-01 | 0.1617 |
11068 | CYB561D2 | P22T-E | Human | Esophagus | ESCC | 1.14e-14 | 2.66e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CYB561D2 | SNV | Missense_Mutation | c.629N>C | p.Val210Ala | p.V210A | O14569 | protein_coding | deleterious(0) | possibly_damaging(0.696) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CYB561D2 | SNV | Missense_Mutation | c.557C>T | p.Ser186Phe | p.S186F | O14569 | protein_coding | tolerated(0.1) | benign(0.046) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD | |
CYB561D2 | deletion | Frame_Shift_Del | novel | c.152delN | p.Met52CysfsTer8 | p.M52Cfs*8 | O14569 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
CYB561D2 | SNV | Missense_Mutation | novel | c.493N>T | p.Val165Leu | p.V165L | O14569 | protein_coding | tolerated(0.38) | benign(0.006) | TCGA-AG-A00Y-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CYB561D2 | SNV | Missense_Mutation | novel | c.301N>A | p.Leu101Ile | p.L101I | O14569 | protein_coding | deleterious(0.02) | benign(0.148) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CYB561D2 | SNV | Missense_Mutation | c.67N>A | p.Ala23Thr | p.A23T | O14569 | protein_coding | tolerated(0.23) | benign(0.013) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CYB561D2 | SNV | Missense_Mutation | rs779823879 | c.251N>A | p.Arg84His | p.R84H | O14569 | protein_coding | deleterious(0) | benign(0.007) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYB561D2 | SNV | Missense_Mutation | c.67N>A | p.Ala23Thr | p.A23T | O14569 | protein_coding | tolerated(0.23) | benign(0.013) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
CYB561D2 | SNV | Missense_Mutation | novel | c.16G>A | p.Glu6Lys | p.E6K | O14569 | protein_coding | tolerated(0.12) | benign(0.355) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CYB561D2 | SNV | Missense_Mutation | novel | c.148N>T | p.Val50Leu | p.V50L | O14569 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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