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Gene: CCT5 |
Gene summary for CCT5 |
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Gene information | Species | Human | Gene symbol | CCT5 | Gene ID | 22948 |
Gene name | chaperonin containing TCP1 subunit 5 | |
Gene Alias | CCT-epsilon | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | B4DX08 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22948 | CCT5 | GSM4909282 | Human | Breast | IDC | 2.85e-20 | 5.90e-01 | -0.0288 |
22948 | CCT5 | GSM4909285 | Human | Breast | IDC | 4.43e-23 | 6.30e-01 | 0.21 |
22948 | CCT5 | GSM4909286 | Human | Breast | IDC | 1.57e-03 | -6.90e-02 | 0.1081 |
22948 | CCT5 | GSM4909288 | Human | Breast | IDC | 3.72e-04 | 3.12e-01 | 0.0988 |
22948 | CCT5 | GSM4909293 | Human | Breast | IDC | 9.82e-03 | -1.12e-01 | 0.1581 |
22948 | CCT5 | GSM4909296 | Human | Breast | IDC | 2.19e-11 | -3.38e-01 | 0.1524 |
22948 | CCT5 | GSM4909297 | Human | Breast | IDC | 3.63e-07 | -8.96e-02 | 0.1517 |
22948 | CCT5 | GSM4909301 | Human | Breast | IDC | 2.05e-04 | -2.72e-01 | 0.1577 |
22948 | CCT5 | GSM4909307 | Human | Breast | IDC | 6.30e-06 | -2.84e-01 | 0.1569 |
22948 | CCT5 | GSM4909311 | Human | Breast | IDC | 1.89e-25 | -2.72e-01 | 0.1534 |
22948 | CCT5 | GSM4909312 | Human | Breast | IDC | 1.01e-06 | -4.73e-02 | 0.1552 |
22948 | CCT5 | GSM4909313 | Human | Breast | IDC | 6.29e-05 | -2.99e-01 | 0.0391 |
22948 | CCT5 | GSM4909318 | Human | Breast | IDC | 3.11e-09 | 7.13e-01 | 0.2031 |
22948 | CCT5 | GSM4909319 | Human | Breast | IDC | 8.51e-27 | -3.80e-01 | 0.1563 |
22948 | CCT5 | GSM4909320 | Human | Breast | IDC | 1.30e-02 | -3.16e-01 | 0.1575 |
22948 | CCT5 | GSM4909321 | Human | Breast | IDC | 9.26e-09 | -1.47e-01 | 0.1559 |
22948 | CCT5 | brca1 | Human | Breast | Precancer | 8.88e-31 | 6.44e-01 | -0.0338 |
22948 | CCT5 | brca2 | Human | Breast | Precancer | 2.36e-11 | 4.02e-01 | -0.024 |
22948 | CCT5 | brca3 | Human | Breast | Precancer | 4.68e-05 | 3.82e-01 | -0.0263 |
22948 | CCT5 | M2 | Human | Breast | IDC | 1.03e-18 | 7.91e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00064578 | Breast | Precancer | protein folding | 43/1080 | 212/18723 | 3.48e-13 | 7.45e-11 | 43 |
GO:00508219 | Breast | Precancer | protein stabilization | 29/1080 | 191/18723 | 1.67e-06 | 6.08e-05 | 29 |
GO:00316479 | Breast | Precancer | regulation of protein stability | 38/1080 | 298/18723 | 3.73e-06 | 1.19e-04 | 38 |
GO:00108338 | Breast | Precancer | telomere maintenance via telomere lengthening | 15/1080 | 81/18723 | 5.31e-05 | 1.11e-03 | 15 |
GO:00007238 | Breast | Precancer | telomere maintenance | 20/1080 | 131/18723 | 6.10e-05 | 1.25e-03 | 20 |
GO:19901734 | Breast | Precancer | protein localization to nucleoplasm | 6/1080 | 14/18723 | 7.30e-05 | 1.44e-03 | 6 |
GO:20005738 | Breast | Precancer | positive regulation of DNA biosynthetic process | 13/1080 | 66/18723 | 8.54e-05 | 1.63e-03 | 13 |
GO:19049519 | Breast | Precancer | positive regulation of establishment of protein localization | 36/1080 | 319/18723 | 9.30e-05 | 1.75e-03 | 36 |
GO:19048743 | Breast | Precancer | positive regulation of telomerase RNA localization to Cajal body | 6/1080 | 15/18723 | 1.16e-04 | 2.08e-03 | 6 |
GO:19048516 | Breast | Precancer | positive regulation of establishment of protein localization to telomere | 5/1080 | 10/18723 | 1.25e-04 | 2.21e-03 | 5 |
GO:00070047 | Breast | Precancer | telomere maintenance via telomerase | 13/1080 | 69/18723 | 1.37e-04 | 2.38e-03 | 13 |
GO:19043567 | Breast | Precancer | regulation of telomere maintenance via telomere lengthening | 12/1080 | 61/18723 | 1.61e-04 | 2.69e-03 | 12 |
GO:19043588 | Breast | Precancer | positive regulation of telomere maintenance via telomere lengthening | 9/1080 | 37/18723 | 1.96e-04 | 3.10e-03 | 9 |
GO:00702034 | Breast | Precancer | regulation of establishment of protein localization to telomere | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048694 | Breast | Precancer | regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:19048714 | Breast | Precancer | positive regulation of protein localization to Cajal body | 5/1080 | 11/18723 | 2.18e-04 | 3.35e-03 | 5 |
GO:00062786 | Breast | Precancer | RNA-dependent DNA biosynthetic process | 13/1080 | 75/18723 | 3.27e-04 | 4.64e-03 | 13 |
GO:0035036 | Breast | Precancer | sperm-egg recognition | 10/1080 | 48/18723 | 3.43e-04 | 4.81e-03 | 10 |
GO:00702026 | Breast | Precancer | regulation of establishment of protein localization to chromosome | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
GO:19034053 | Breast | Precancer | protein localization to nuclear body | 5/1080 | 12/18723 | 3.56e-04 | 4.93e-03 | 5 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT5 | SNV | Missense_Mutation | rs762786367 | c.1046N>T | p.Thr349Ile | p.T349I | P48643 | protein_coding | deleterious(0) | possibly_damaging(0.71) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
CCT5 | SNV | Missense_Mutation | c.1031G>T | p.Arg344Met | p.R344M | P48643 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CCT5 | SNV | Missense_Mutation | c.1018C>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
CCT5 | SNV | Missense_Mutation | c.1018N>T | p.Arg340Trp | p.R340W | P48643 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006G>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | novel | c.359N>T | p.Ala120Val | p.A120V | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | rs768768696 | c.1006N>A | p.Ala336Thr | p.A336T | P48643 | protein_coding | tolerated(0.07) | benign(0.325) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CCT5 | SNV | Missense_Mutation | c.338N>A | p.Ala113Asp | p.A113D | P48643 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
CCT5 | SNV | Missense_Mutation | novel | c.819N>G | p.Asp273Glu | p.D273E | P48643 | protein_coding | tolerated(1) | benign(0.019) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
CCT5 | SNV | Missense_Mutation | c.1400N>A | p.Gly467Asp | p.G467D | P48643 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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