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Gene: C5orf28 |
Gene summary for C5ORF28 |
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Gene information | Species | Human | Gene symbol | C5orf28 | Gene ID | 64417 |
Gene name | transmembrane protein 267 | |
Gene Alias | C5orf28 | |
Cytomap | 5p12 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R0B8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64417 | C5orf28 | P2T-E | Human | Esophagus | ESCC | 9.02e-11 | 1.82e-01 | 0.1177 |
64417 | C5orf28 | P4T-E | Human | Esophagus | ESCC | 3.85e-16 | 3.58e-01 | 0.1323 |
64417 | C5orf28 | P5T-E | Human | Esophagus | ESCC | 8.56e-12 | 2.85e-01 | 0.1327 |
64417 | C5orf28 | P8T-E | Human | Esophagus | ESCC | 1.75e-25 | 3.88e-01 | 0.0889 |
64417 | C5orf28 | P9T-E | Human | Esophagus | ESCC | 1.08e-07 | 2.02e-01 | 0.1131 |
64417 | C5orf28 | P10T-E | Human | Esophagus | ESCC | 8.08e-19 | 2.80e-01 | 0.116 |
64417 | C5orf28 | P11T-E | Human | Esophagus | ESCC | 1.06e-12 | 4.02e-01 | 0.1426 |
64417 | C5orf28 | P12T-E | Human | Esophagus | ESCC | 2.06e-08 | 2.17e-01 | 0.1122 |
64417 | C5orf28 | P15T-E | Human | Esophagus | ESCC | 5.19e-07 | 1.63e-01 | 0.1149 |
64417 | C5orf28 | P16T-E | Human | Esophagus | ESCC | 2.03e-09 | 2.55e-01 | 0.1153 |
64417 | C5orf28 | P17T-E | Human | Esophagus | ESCC | 3.52e-10 | 3.73e-01 | 0.1278 |
64417 | C5orf28 | P20T-E | Human | Esophagus | ESCC | 7.88e-10 | 2.38e-01 | 0.1124 |
64417 | C5orf28 | P21T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.70e-01 | 0.1617 |
64417 | C5orf28 | P22T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.32e-01 | 0.1236 |
64417 | C5orf28 | P23T-E | Human | Esophagus | ESCC | 1.18e-21 | 4.68e-01 | 0.108 |
64417 | C5orf28 | P24T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.45e-01 | 0.1287 |
64417 | C5orf28 | P26T-E | Human | Esophagus | ESCC | 1.47e-14 | 2.56e-01 | 0.1276 |
64417 | C5orf28 | P27T-E | Human | Esophagus | ESCC | 4.12e-11 | 2.57e-01 | 0.1055 |
64417 | C5orf28 | P28T-E | Human | Esophagus | ESCC | 4.17e-05 | 1.28e-01 | 0.1149 |
64417 | C5orf28 | P30T-E | Human | Esophagus | ESCC | 2.89e-13 | 4.03e-01 | 0.137 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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