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Gene: C2orf74 |
Gene summary for C2ORF74 |
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Gene information | Species | Human | Gene symbol | C2orf74 | Gene ID | 339804 |
Gene name | chromosome 2 open reading frame 74 | |
Gene Alias | C2orf74 | |
Cytomap | 2p15 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A8MZ97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
339804 | C2orf74 | LZE4T | Human | Esophagus | ESCC | 3.86e-11 | 2.71e-01 | 0.0811 |
339804 | C2orf74 | LZE24T | Human | Esophagus | ESCC | 2.66e-16 | 3.79e-01 | 0.0596 |
339804 | C2orf74 | LZE6T | Human | Esophagus | ESCC | 2.96e-03 | 1.72e-01 | 0.0845 |
339804 | C2orf74 | P1T-E | Human | Esophagus | ESCC | 3.50e-13 | 4.63e-01 | 0.0875 |
339804 | C2orf74 | P4T-E | Human | Esophagus | ESCC | 3.52e-15 | 3.22e-01 | 0.1323 |
339804 | C2orf74 | P5T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.94e-01 | 0.1327 |
339804 | C2orf74 | P8T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.28e-01 | 0.0889 |
339804 | C2orf74 | P9T-E | Human | Esophagus | ESCC | 2.30e-02 | 1.01e-01 | 0.1131 |
339804 | C2orf74 | P10T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.44e-01 | 0.116 |
339804 | C2orf74 | P12T-E | Human | Esophagus | ESCC | 3.60e-13 | 2.89e-01 | 0.1122 |
339804 | C2orf74 | P16T-E | Human | Esophagus | ESCC | 4.24e-18 | 2.88e-01 | 0.1153 |
339804 | C2orf74 | P17T-E | Human | Esophagus | ESCC | 1.49e-02 | 1.41e-01 | 0.1278 |
339804 | C2orf74 | P20T-E | Human | Esophagus | ESCC | 3.17e-29 | 4.83e-01 | 0.1124 |
339804 | C2orf74 | P21T-E | Human | Esophagus | ESCC | 7.74e-41 | 6.97e-01 | 0.1617 |
339804 | C2orf74 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.57e-01 | 0.1236 |
339804 | C2orf74 | P23T-E | Human | Esophagus | ESCC | 2.37e-12 | 3.30e-01 | 0.108 |
339804 | C2orf74 | P24T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.76e-01 | 0.1287 |
339804 | C2orf74 | P30T-E | Human | Esophagus | ESCC | 9.20e-05 | 1.89e-01 | 0.137 |
339804 | C2orf74 | P31T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.18e-01 | 0.1251 |
339804 | C2orf74 | P32T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.00e-01 | 0.1666 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C2orf74 | insertion | In_Frame_Ins | novel | c.255_256insGTGACATTTTCTAGGGAGGTAATTGTTGTGGATCTTGGGAAT | p.Val86_Asn99dup | p.V86_N99dup | protein_coding | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
C2orf74 | SNV | Missense_Mutation | novel | c.141N>T | p.Glu47Asp | p.E47D | protein_coding | tolerated(0.51) | benign(0.003) | TCGA-EK-A2IP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.57N>C | p.Gln19His | p.Q19H | protein_coding | tolerated(0.08) | benign(0.077) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.242N>T | p.Arg81Ile | p.R81I | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
C2orf74 | SNV | Missense_Mutation | rs574904888 | c.314N>A | p.Arg105Gln | p.R105Q | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
C2orf74 | SNV | Missense_Mutation | rs771315443 | c.326N>A | p.Arg109Gln | p.R109Q | protein_coding | tolerated(0.19) | benign(0.06) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.281N>G | p.Val94Gly | p.V94G | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.235N>A | p.Gln79Lys | p.Q79K | protein_coding | deleterious(0.04) | benign(0.167) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C2orf74 | SNV | Missense_Mutation | novel | c.174N>T | p.Glu58Asp | p.E58D | protein_coding | tolerated(0.6) | benign(0.328) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD | |
C2orf74 | SNV | Missense_Mutation | rs574904888 | c.314G>A | p.Arg105Gln | p.R105Q | protein_coding | tolerated(0.57) | benign(0.007) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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