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Gene: C14orf166 |
Gene summary for C14ORF166 |
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Gene information | Species | Human | Gene symbol | C14orf166 | Gene ID | 51637 |
Gene name | RNA transcription, translation and transport factor | |
Gene Alias | C14orf166 | |
Cytomap | 14q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000394 | UniProtAcc | Q549M8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51637 | C14orf166 | GSM4909281 | Human | Breast | IDC | 2.44e-15 | -2.90e-01 | 0.21 |
51637 | C14orf166 | GSM4909282 | Human | Breast | IDC | 2.44e-15 | -2.90e-01 | -0.0288 |
51637 | C14orf166 | GSM4909285 | Human | Breast | IDC | 2.44e-15 | -2.90e-01 | 0.21 |
51637 | C14orf166 | GSM4909286 | Human | Breast | IDC | 5.48e-15 | -2.90e-01 | 0.1081 |
51637 | C14orf166 | GSM4909287 | Human | Breast | IDC | 4.02e-18 | -2.90e-01 | 0.2057 |
51637 | C14orf166 | GSM4909288 | Human | Breast | IDC | 8.02e-04 | -2.90e-01 | 0.0988 |
51637 | C14orf166 | GSM4909289 | Human | Breast | IDC | 1.80e-02 | -2.90e-01 | 0.1064 |
51637 | C14orf166 | GSM4909290 | Human | Breast | IDC | 7.88e-13 | -2.90e-01 | 0.2096 |
51637 | C14orf166 | GSM4909291 | Human | Breast | IDC | 2.70e-10 | -2.90e-01 | 0.1753 |
51637 | C14orf166 | GSM4909293 | Human | Breast | IDC | 1.08e-15 | -2.90e-01 | 0.1581 |
51637 | C14orf166 | GSM4909294 | Human | Breast | IDC | 2.12e-16 | -2.90e-01 | 0.2022 |
51637 | C14orf166 | GSM4909295 | Human | Breast | IDC | 5.68e-08 | -2.90e-01 | 0.0898 |
51637 | C14orf166 | GSM4909296 | Human | Breast | IDC | 1.08e-15 | -2.90e-01 | 0.1524 |
51637 | C14orf166 | GSM4909297 | Human | Breast | IDC | 1.51e-18 | -2.90e-01 | 0.1517 |
51637 | C14orf166 | GSM4909298 | Human | Breast | IDC | 4.12e-17 | -2.90e-01 | 0.1551 |
51637 | C14orf166 | GSM4909299 | Human | Breast | IDC | 4.80e-16 | -2.90e-01 | 0.035 |
51637 | C14orf166 | GSM4909300 | Human | Breast | IDC | 5.69e-07 | -2.90e-01 | 0.0334 |
51637 | C14orf166 | GSM4909301 | Human | Breast | IDC | 4.12e-17 | -2.90e-01 | 0.1577 |
51637 | C14orf166 | GSM4909302 | Human | Breast | IDC | 7.44e-18 | -2.90e-01 | 0.1545 |
51637 | C14orf166 | GSM4909303 | Human | Breast | IDC | 1.98e-04 | -2.90e-01 | 0.0438 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C14orf166 | insertion | Frame_Shift_Ins | novel | c.623_624insTGGG | p.Ile209GlyfsTer25 | p.I209Gfs*25 | Q9Y224 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
C14orf166 | SNV | Missense_Mutation | c.562N>A | p.Leu188Ile | p.L188I | Q9Y224 | protein_coding | tolerated(0.13) | benign(0.207) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
C14orf166 | SNV | Missense_Mutation | c.177C>A | p.Phe59Leu | p.F59L | Q9Y224 | protein_coding | tolerated(0.64) | benign(0) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
C14orf166 | SNV | Missense_Mutation | rs748105780 | c.41N>T | p.Pro14Leu | p.P14L | Q9Y224 | protein_coding | tolerated(0.46) | probably_damaging(0.951) | TCGA-D5-6932-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
C14orf166 | SNV | Missense_Mutation | c.562C>A | p.Leu188Ile | p.L188I | Q9Y224 | protein_coding | tolerated(0.13) | benign(0.207) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C14orf166 | SNV | Missense_Mutation | c.377A>C | p.Asn126Thr | p.N126T | Q9Y224 | protein_coding | deleterious(0.02) | benign(0.01) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
C14orf166 | SNV | Missense_Mutation | novel | c.82N>C | p.Phe28Leu | p.F28L | Q9Y224 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
C14orf166 | SNV | Missense_Mutation | novel | c.560N>G | p.Ile187Ser | p.I187S | Q9Y224 | protein_coding | tolerated(0.74) | benign(0.062) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
C14orf166 | SNV | Missense_Mutation | c.562N>T | p.Leu188Phe | p.L188F | Q9Y224 | protein_coding | deleterious(0.02) | possibly_damaging(0.65) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C14orf166 | SNV | Missense_Mutation | c.215N>G | p.Lys72Arg | p.K72R | Q9Y224 | protein_coding | tolerated(0.28) | benign(0.174) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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