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Gene: ARMC7 |
Gene summary for ARMC7 |
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Gene information | Species | Human | Gene symbol | ARMC7 | Gene ID | 79637 |
Gene name | armadillo repeat containing 7 | |
Gene Alias | ARMC7 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9H6L4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79637 | ARMC7 | LZE4T | Human | Esophagus | ESCC | 3.20e-03 | 1.45e-01 | 0.0811 |
79637 | ARMC7 | LZE20T | Human | Esophagus | ESCC | 4.11e-02 | 1.13e-01 | 0.0662 |
79637 | ARMC7 | LZE22T | Human | Esophagus | ESCC | 1.26e-02 | 3.98e-01 | 0.068 |
79637 | ARMC7 | LZE24T | Human | Esophagus | ESCC | 5.81e-07 | 1.95e-01 | 0.0596 |
79637 | ARMC7 | LZE21T | Human | Esophagus | ESCC | 3.02e-02 | 2.13e-01 | 0.0655 |
79637 | ARMC7 | P2T-E | Human | Esophagus | ESCC | 2.19e-10 | 6.91e-02 | 0.1177 |
79637 | ARMC7 | P5T-E | Human | Esophagus | ESCC | 7.34e-03 | 2.84e-02 | 0.1327 |
79637 | ARMC7 | P8T-E | Human | Esophagus | ESCC | 1.99e-08 | 1.07e-01 | 0.0889 |
79637 | ARMC7 | P9T-E | Human | Esophagus | ESCC | 4.94e-05 | 1.38e-01 | 0.1131 |
79637 | ARMC7 | P10T-E | Human | Esophagus | ESCC | 4.68e-22 | 2.76e-01 | 0.116 |
79637 | ARMC7 | P11T-E | Human | Esophagus | ESCC | 2.61e-03 | 2.20e-01 | 0.1426 |
79637 | ARMC7 | P12T-E | Human | Esophagus | ESCC | 1.31e-14 | 1.81e-01 | 0.1122 |
79637 | ARMC7 | P15T-E | Human | Esophagus | ESCC | 3.96e-10 | 2.62e-01 | 0.1149 |
79637 | ARMC7 | P16T-E | Human | Esophagus | ESCC | 8.00e-17 | 1.06e-01 | 0.1153 |
79637 | ARMC7 | P20T-E | Human | Esophagus | ESCC | 7.67e-28 | 5.63e-01 | 0.1124 |
79637 | ARMC7 | P21T-E | Human | Esophagus | ESCC | 1.64e-09 | 1.70e-01 | 0.1617 |
79637 | ARMC7 | P22T-E | Human | Esophagus | ESCC | 1.22e-19 | 1.64e-01 | 0.1236 |
79637 | ARMC7 | P24T-E | Human | Esophagus | ESCC | 1.32e-06 | 8.17e-02 | 0.1287 |
79637 | ARMC7 | P26T-E | Human | Esophagus | ESCC | 1.08e-11 | 1.82e-01 | 0.1276 |
79637 | ARMC7 | P27T-E | Human | Esophagus | ESCC | 4.25e-04 | 9.31e-02 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARMC7 | SNV | Missense_Mutation | c.256N>A | p.Pro86Thr | p.P86T | Q9H6L4 | protein_coding | tolerated(0.39) | benign(0.021) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ARMC7 | SNV | Missense_Mutation | c.211G>A | p.Glu71Lys | p.E71K | Q9H6L4 | protein_coding | deleterious(0.02) | benign(0.372) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | |
ARMC7 | SNV | Missense_Mutation | novel | c.50T>C | p.Leu17Pro | p.L17P | Q9H6L4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ARMC7 | SNV | Missense_Mutation | novel | c.214N>T | p.Thr72Ser | p.T72S | Q9H6L4 | protein_coding | tolerated(0.31) | benign(0) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARMC7 | SNV | Missense_Mutation | novel | c.151N>A | p.Glu51Lys | p.E51K | Q9H6L4 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-DD-AACN-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ARMC7 | SNV | Missense_Mutation | novel | c.83N>T | p.Gln28Leu | p.Q28L | Q9H6L4 | protein_coding | tolerated(0.09) | benign(0.021) | TCGA-05-4424-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Targeted Molecular therapy | erlotinib | SD |
ARMC7 | SNV | Missense_Mutation | c.204G>T | p.Glu68Asp | p.E68D | Q9H6L4 | protein_coding | tolerated(0.09) | benign(0.174) | TCGA-99-8025-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | gemzar | SD | |
ARMC7 | SNV | Missense_Mutation | rs752190084 | c.383N>T | p.Pro128Leu | p.P128L | Q9H6L4 | protein_coding | deleterious(0.03) | benign(0.024) | TCGA-37-A5EL-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | temodal | PD |
ARMC7 | SNV | Missense_Mutation | c.200C>G | p.Ser67Trp | p.S67W | Q9H6L4 | protein_coding | deleterious(0) | probably_damaging(0.937) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | |
ARMC7 | SNV | Missense_Mutation | novel | c.139N>A | p.Pro47Thr | p.P47T | Q9H6L4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CN-A6V1-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Immunotherapy | erbitux | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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