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Gene: ARID3A |
Gene summary for ARID3A |
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Gene information | Species | Human | Gene symbol | ARID3A | Gene ID | 1820 |
Gene name | AT-rich interaction domain 3A | |
Gene Alias | BRIGHT | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q99856 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1820 | ARID3A | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.50e-04 | 1.84e-01 | 0.0155 |
1820 | ARID3A | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.17e-03 | 4.22e-01 | 0.0216 |
1820 | ARID3A | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.85e-12 | 4.46e-01 | -0.0811 |
1820 | ARID3A | HTA11_78_2000001011 | Human | Colorectum | AD | 1.40e-04 | 3.09e-01 | -0.1088 |
1820 | ARID3A | HTA11_347_2000001011 | Human | Colorectum | AD | 7.11e-03 | 7.91e-02 | -0.1954 |
1820 | ARID3A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.76e-05 | 3.56e-01 | -0.1207 |
1820 | ARID3A | HTA11_696_2000001011 | Human | Colorectum | AD | 6.36e-03 | 2.33e-01 | -0.1464 |
1820 | ARID3A | HTA11_866_2000001011 | Human | Colorectum | AD | 3.68e-10 | 3.58e-01 | -0.1001 |
1820 | ARID3A | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.89e-04 | 2.30e-01 | -0.059 |
1820 | ARID3A | HTA11_546_2000001011 | Human | Colorectum | AD | 8.11e-05 | 3.85e-01 | -0.0842 |
1820 | ARID3A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.88e-17 | 4.66e-01 | 0.096 |
1820 | ARID3A | HTA11_9408_2000001011 | Human | Colorectum | AD | 2.86e-02 | 4.54e-01 | 0.0451 |
1820 | ARID3A | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.96e-09 | 4.09e-01 | 0.0338 |
1820 | ARID3A | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.00e-20 | 5.36e-01 | 0.0674 |
1820 | ARID3A | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.65e-07 | 4.75e-01 | 0.0112 |
1820 | ARID3A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.25e-17 | 5.69e-01 | 0.0588 |
1820 | ARID3A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.92e-11 | 3.65e-01 | 0.281 |
1820 | ARID3A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.72e-24 | 6.70e-01 | 0.3859 |
1820 | ARID3A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.00e-35 | 1.35e+00 | 0.2585 |
1820 | ARID3A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.69e-34 | 7.74e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Oral cavity | OSCC | ![]() |
Oral cavity | LP | ![]() |
Oral cavity | EOLP | ![]() |
Oral cavity | NEOLP | ![]() |
Esophagus | HGIN | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARID3A | SNV | Missense_Mutation | c.302N>T | p.Ser101Leu | p.S101L | Q99856 | protein_coding | deleterious_low_confidence(0.02) | benign(0.108) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARID3A | SNV | Missense_Mutation | c.867N>G | p.Ile289Met | p.I289M | Q99856 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ARID3A | insertion | Nonsense_Mutation | novel | c.1766_1767insGTTTAAGCTGGGCTCACGTCTGTAATCCCAGCACTT | p.Asn589delinsLysPheLysLeuGlySerArgLeuTerSerGlnHisPhe | p.N589delinsKFKLGSRL*SQHF | Q99856 | protein_coding | TCGA-B6-A0I6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
ARID3A | SNV | Missense_Mutation | c.947C>G | p.Thr316Ser | p.T316S | Q99856 | protein_coding | deleterious(0.03) | possibly_damaging(0.886) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
ARID3A | SNV | Missense_Mutation | c.1473G>C | p.Met491Ile | p.M491I | Q99856 | protein_coding | deleterious(0) | benign(0.119) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARID3A | SNV | Missense_Mutation | novel | c.535C>T | p.Pro179Ser | p.P179S | Q99856 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARID3A | SNV | Missense_Mutation | rs150609955 | c.1733C>T | p.Ala578Val | p.A578V | Q99856 | protein_coding | deleterious_low_confidence(0.01) | benign(0.063) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARID3A | SNV | Missense_Mutation | c.964N>A | p.Leu322Met | p.L322M | Q99856 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARID3A | SNV | Missense_Mutation | rs145361495 | c.988C>T | p.Arg330Trp | p.R330W | Q99856 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARID3A | SNV | Missense_Mutation | novel | c.352G>A | p.Ala118Thr | p.A118T | Q99856 | protein_coding | tolerated_low_confidence(0.06) | benign(0.018) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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