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Gene: ZNF805 |
Gene summary for ZNF805 |
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Gene information | Species | Human | Gene symbol | ZNF805 | Gene ID | 390980 |
Gene name | zinc finger protein 805 | |
Gene Alias | ZNF805 | |
Cytomap | 19q13.43 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5CZA5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
390980 | ZNF805 | HCC1 | Human | Liver | HCC | 1.33e-05 | 2.53e+00 | 0.5336 |
390980 | ZNF805 | HCC2 | Human | Liver | HCC | 1.60e-10 | 1.68e+00 | 0.5341 |
390980 | ZNF805 | S027 | Human | Liver | HCC | 2.57e-02 | 1.59e-01 | 0.2446 |
390980 | ZNF805 | S029 | Human | Liver | HCC | 1.62e-03 | 1.45e-01 | 0.2581 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF805 | SNV | Missense_Mutation | c.286N>G | p.Thr96Ala | p.T96A | Q5CZA5 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-A8-A08G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
ZNF805 | SNV | Missense_Mutation | rs770566139 | c.1435N>A | p.Gly479Arg | p.G479R | Q5CZA5 | protein_coding | deleterious(0.01) | probably_damaging(0.987) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF805 | SNV | Missense_Mutation | c.835C>T | p.Arg279Trp | p.R279W | Q5CZA5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ZNF805 | SNV | Missense_Mutation | novel | c.1691N>A | p.Arg564Lys | p.R564K | Q5CZA5 | protein_coding | tolerated(0.41) | benign(0) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF805 | SNV | Missense_Mutation | c.1097N>T | p.Thr366Ile | p.T366I | Q5CZA5 | protein_coding | deleterious(0) | possibly_damaging(0.873) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
ZNF805 | SNV | Missense_Mutation | novel | c.1046N>A | p.Gly349Asp | p.G349D | Q5CZA5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF805 | SNV | Missense_Mutation | c.262N>C | p.Gly88Arg | p.G88R | Q5CZA5 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-EK-A2PM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF805 | SNV | Missense_Mutation | c.1114N>A | p.Glu372Lys | p.E372K | Q5CZA5 | protein_coding | tolerated(0.15) | benign(0.178) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
ZNF805 | SNV | Missense_Mutation | novel | c.590N>G | p.Gln197Arg | p.Q197R | Q5CZA5 | protein_coding | tolerated(0.35) | benign(0) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
ZNF805 | SNV | Missense_Mutation | c.262G>A | p.Gly88Arg | p.G88R | Q5CZA5 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-A6-6137-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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