![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: ZNF672 |
Gene summary for ZNF672 |
![]() |
Gene information | Species | Human | Gene symbol | ZNF672 | Gene ID | 79894 |
Gene name | zinc finger protein 672 | |
Gene Alias | ZNF672 | |
Cytomap | 1q44 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q499Z4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79894 | ZNF672 | LZE24T | Human | Esophagus | ESCC | 4.39e-11 | 3.11e-01 | 0.0596 |
79894 | ZNF672 | LZE21T | Human | Esophagus | ESCC | 3.72e-03 | 1.63e-01 | 0.0655 |
79894 | ZNF672 | P1T-E | Human | Esophagus | ESCC | 8.30e-05 | 2.34e-01 | 0.0875 |
79894 | ZNF672 | P2T-E | Human | Esophagus | ESCC | 2.26e-15 | 2.41e-01 | 0.1177 |
79894 | ZNF672 | P4T-E | Human | Esophagus | ESCC | 1.80e-02 | 5.13e-02 | 0.1323 |
79894 | ZNF672 | P5T-E | Human | Esophagus | ESCC | 6.69e-09 | 1.19e-01 | 0.1327 |
79894 | ZNF672 | P8T-E | Human | Esophagus | ESCC | 1.17e-08 | 9.87e-02 | 0.0889 |
79894 | ZNF672 | P9T-E | Human | Esophagus | ESCC | 1.43e-11 | 1.46e-01 | 0.1131 |
79894 | ZNF672 | P10T-E | Human | Esophagus | ESCC | 2.07e-06 | 1.06e-01 | 0.116 |
79894 | ZNF672 | P11T-E | Human | Esophagus | ESCC | 1.37e-09 | 3.33e-01 | 0.1426 |
79894 | ZNF672 | P12T-E | Human | Esophagus | ESCC | 2.86e-18 | 2.02e-01 | 0.1122 |
79894 | ZNF672 | P15T-E | Human | Esophagus | ESCC | 2.94e-11 | 2.04e-01 | 0.1149 |
79894 | ZNF672 | P16T-E | Human | Esophagus | ESCC | 9.48e-06 | 9.28e-02 | 0.1153 |
79894 | ZNF672 | P17T-E | Human | Esophagus | ESCC | 5.54e-04 | 2.71e-01 | 0.1278 |
79894 | ZNF672 | P19T-E | Human | Esophagus | ESCC | 2.16e-02 | 2.39e-01 | 0.1662 |
79894 | ZNF672 | P20T-E | Human | Esophagus | ESCC | 1.21e-10 | 1.03e-01 | 0.1124 |
79894 | ZNF672 | P21T-E | Human | Esophagus | ESCC | 2.52e-10 | 2.38e-01 | 0.1617 |
79894 | ZNF672 | P22T-E | Human | Esophagus | ESCC | 2.85e-05 | 9.30e-02 | 0.1236 |
79894 | ZNF672 | P23T-E | Human | Esophagus | ESCC | 1.78e-14 | 3.32e-01 | 0.108 |
79894 | ZNF672 | P24T-E | Human | Esophagus | ESCC | 5.88e-07 | 1.16e-01 | 0.1287 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF672 | SNV | Missense_Mutation | c.196G>A | p.Gly66Ser | p.G66S | Q499Z4 | protein_coding | deleterious(0) | benign(0.405) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
ZNF672 | SNV | Missense_Mutation | c.887C>T | p.Ser296Phe | p.S296F | Q499Z4 | protein_coding | deleterious(0) | possibly_damaging(0.447) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
ZNF672 | SNV | Missense_Mutation | novel | c.1069C>T | p.His357Tyr | p.H357Y | Q499Z4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ZNF672 | SNV | Missense_Mutation | novel | c.956N>A | p.Arg319His | p.R319H | Q499Z4 | protein_coding | tolerated(0.58) | benign(0.005) | TCGA-VS-A9V2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ZNF672 | SNV | Missense_Mutation | novel | c.1001N>T | p.Thr334Met | p.T334M | Q499Z4 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF672 | SNV | Missense_Mutation | c.592N>A | p.Ala198Thr | p.A198T | Q499Z4 | protein_coding | tolerated(0.76) | benign(0) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF672 | SNV | Missense_Mutation | rs756294849 | c.601N>C | p.Cys201Arg | p.C201R | Q499Z4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF672 | SNV | Missense_Mutation | rs774072544 | c.856G>A | p.Ala286Thr | p.A286T | Q499Z4 | protein_coding | tolerated(0.7) | benign(0.003) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
ZNF672 | SNV | Missense_Mutation | c.1262N>A | p.Arg421His | p.R421H | Q499Z4 | protein_coding | tolerated(0.07) | benign(0.003) | TCGA-AZ-5403-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
ZNF672 | SNV | Missense_Mutation | rs372064469 | c.605N>A | p.Gly202Asp | p.G202D | Q499Z4 | protein_coding | tolerated(0.45) | benign(0.003) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |