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Gene: ZNF562 |
Gene summary for ZNF562 |
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Gene information | Species | Human | Gene symbol | ZNF562 | Gene ID | 54811 |
Gene name | zinc finger protein 562 | |
Gene Alias | ZNF562 | |
Cytomap | 19p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A024R7A3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54811 | ZNF562 | LZE4T | Human | Esophagus | ESCC | 5.82e-05 | 1.28e-01 | 0.0811 |
54811 | ZNF562 | LZE7T | Human | Esophagus | ESCC | 2.36e-09 | 3.31e-01 | 0.0667 |
54811 | ZNF562 | LZE8T | Human | Esophagus | ESCC | 8.99e-03 | 8.29e-02 | 0.067 |
54811 | ZNF562 | LZE20T | Human | Esophagus | ESCC | 1.68e-03 | 9.12e-02 | 0.0662 |
54811 | ZNF562 | LZE24T | Human | Esophagus | ESCC | 6.42e-09 | 2.83e-01 | 0.0596 |
54811 | ZNF562 | P1T-E | Human | Esophagus | ESCC | 4.22e-05 | 3.14e-01 | 0.0875 |
54811 | ZNF562 | P2T-E | Human | Esophagus | ESCC | 1.71e-12 | 7.67e-02 | 0.1177 |
54811 | ZNF562 | P4T-E | Human | Esophagus | ESCC | 2.64e-05 | 1.83e-01 | 0.1323 |
54811 | ZNF562 | P5T-E | Human | Esophagus | ESCC | 1.31e-14 | 1.83e-01 | 0.1327 |
54811 | ZNF562 | P8T-E | Human | Esophagus | ESCC | 7.20e-17 | 2.11e-01 | 0.0889 |
54811 | ZNF562 | P9T-E | Human | Esophagus | ESCC | 8.08e-12 | 2.54e-01 | 0.1131 |
54811 | ZNF562 | P10T-E | Human | Esophagus | ESCC | 2.11e-13 | 1.82e-01 | 0.116 |
54811 | ZNF562 | P11T-E | Human | Esophagus | ESCC | 1.12e-02 | 2.51e-01 | 0.1426 |
54811 | ZNF562 | P12T-E | Human | Esophagus | ESCC | 3.22e-12 | 1.35e-01 | 0.1122 |
54811 | ZNF562 | P15T-E | Human | Esophagus | ESCC | 2.40e-05 | 7.93e-02 | 0.1149 |
54811 | ZNF562 | P16T-E | Human | Esophagus | ESCC | 8.35e-09 | 6.89e-02 | 0.1153 |
54811 | ZNF562 | P20T-E | Human | Esophagus | ESCC | 5.09e-03 | 1.42e-01 | 0.1124 |
54811 | ZNF562 | P21T-E | Human | Esophagus | ESCC | 8.06e-08 | 8.17e-02 | 0.1617 |
54811 | ZNF562 | P22T-E | Human | Esophagus | ESCC | 1.74e-09 | 1.18e-01 | 0.1236 |
54811 | ZNF562 | P23T-E | Human | Esophagus | ESCC | 6.36e-12 | 2.72e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF562 | SNV | Missense_Mutation | c.216N>C | p.Glu72Asp | p.E72D | Q6V9R5 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
ZNF562 | SNV | Missense_Mutation | novel | c.481N>T | p.Asp161Tyr | p.D161Y | Q6V9R5 | protein_coding | tolerated(0.07) | probably_damaging(0.993) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZNF562 | SNV | Missense_Mutation | rs759010276 | c.103N>G | p.Asn35Asp | p.N35D | Q6V9R5 | protein_coding | tolerated(0.26) | benign(0.099) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ZNF562 | SNV | Missense_Mutation | c.664C>G | p.His222Asp | p.H222D | Q6V9R5 | protein_coding | deleterious(0.02) | probably_damaging(0.991) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
ZNF562 | SNV | Missense_Mutation | novel | c.827N>T | p.Ser276Phe | p.S276F | Q6V9R5 | protein_coding | deleterious(0) | benign(0.121) | TCGA-E2-A1LG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
ZNF562 | SNV | Missense_Mutation | c.325N>G | p.Gln109Glu | p.Q109E | Q6V9R5 | protein_coding | tolerated(0.84) | benign(0) | TCGA-UU-A93S-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
ZNF562 | SNV | Missense_Mutation | c.147G>C | p.Glu49Asp | p.E49D | Q6V9R5 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3697-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF562 | SNV | Missense_Mutation | c.1034A>C | p.Glu345Ala | p.E345A | Q6V9R5 | protein_coding | deleterious(0.02) | possibly_damaging(0.587) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZNF562 | SNV | Missense_Mutation | c.710N>A | p.Cys237Tyr | p.C237Y | Q6V9R5 | protein_coding | deleterious(0.02) | benign(0) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZNF562 | SNV | Missense_Mutation | novel | c.606A>C | p.Gln202His | p.Q202H | Q6V9R5 | protein_coding | deleterious(0.01) | benign(0.28) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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