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Gene: ZNF555 |
Gene summary for ZNF555 |
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Gene information | Species | Human | Gene symbol | ZNF555 | Gene ID | 148254 |
Gene name | zinc finger protein 555 | |
Gene Alias | ZNF555 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8NEP9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
148254 | ZNF555 | HCC1 | Human | Liver | HCC | 2.15e-06 | 6.39e-01 | 0.5336 |
148254 | ZNF555 | HCC2 | Human | Liver | HCC | 5.37e-04 | 1.62e+00 | 0.5341 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZNF555 | SNV | Missense_Mutation | c.806N>T | p.Ser269Leu | p.S269L | Q8NEP9 | protein_coding | tolerated(0.07) | benign(0.012) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
ZNF555 | SNV | Missense_Mutation | novel | c.1615N>G | p.Lys539Glu | p.K539E | Q8NEP9 | protein_coding | tolerated(0.06) | possibly_damaging(0.86) | TCGA-A2-A3XV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
ZNF555 | SNV | Missense_Mutation | c.200N>C | p.Lys67Thr | p.K67T | Q8NEP9 | protein_coding | tolerated(0.27) | benign(0.026) | TCGA-A8-A09Q-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | |
ZNF555 | SNV | Missense_Mutation | c.791N>G | p.Ala264Gly | p.A264G | Q8NEP9 | protein_coding | deleterious(0.03) | possibly_damaging(0.756) | TCGA-D8-A1Y0-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | cyclophosphamide+methotrexatum+fluorouracillum | SD | |
ZNF555 | SNV | Missense_Mutation | c.451G>T | p.Val151Phe | p.V151F | Q8NEP9 | protein_coding | deleterious(0.04) | benign(0.094) | TCGA-E9-A1RC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
ZNF555 | insertion | Nonsense_Mutation | novel | c.1561_1562insCACTCCAGCCTGGGTAACAGAGTAAGACTCTGTCTCA | p.Glu521AlafsTer6 | p.E521Afs*6 | Q8NEP9 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF555 | insertion | Nonsense_Mutation | novel | c.747_748insACATCTTAATCTGTACAAGAAAATTC | p.His250ThrfsTer3 | p.H250Tfs*3 | Q8NEP9 | protein_coding | TCGA-A8-A07B-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZNF555 | insertion | Frame_Shift_Ins | novel | c.732_733insGTACA | p.Ser245ValfsTer34 | p.S245Vfs*34 | Q8NEP9 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF555 | insertion | Nonsense_Mutation | novel | c.734_735insAAAATTCCACCTGGAGTAAAACAGTATGAA | p.Ser245delinsArgLysPheHisLeuGluTerAsnSerMetAsn | p.S245delinsRKFHLE*NSMN | Q8NEP9 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ZNF555 | SNV | Missense_Mutation | novel | c.673G>C | p.Glu225Gln | p.E225Q | Q8NEP9 | protein_coding | deleterious(0.01) | benign(0.085) | TCGA-EA-A5ZE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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