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Gene: WIPF2 |
Gene summary for WIPF2 |
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Gene information | Species | Human | Gene symbol | WIPF2 | Gene ID | 147179 |
Gene name | WAS/WASL interacting protein family member 2 | |
Gene Alias | WICH | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0006928 | UniProtAcc | Q8TF74 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
147179 | WIPF2 | GSM4909291 | Human | Breast | IDC | 7.93e-13 | 5.42e-01 | 0.1753 |
147179 | WIPF2 | GSM4909292 | Human | Breast | IDC | 1.37e-16 | 1.09e+00 | 0.1236 |
147179 | WIPF2 | GSM4909308 | Human | Breast | IDC | 1.13e-03 | 2.50e-01 | 0.158 |
147179 | WIPF2 | GSM4909311 | Human | Breast | IDC | 6.63e-07 | -4.99e-02 | 0.1534 |
147179 | WIPF2 | GSM4909319 | Human | Breast | IDC | 1.81e-08 | -5.32e-02 | 0.1563 |
147179 | WIPF2 | GSM4909321 | Human | Breast | IDC | 3.22e-03 | 3.85e-02 | 0.1559 |
147179 | WIPF2 | NCCBC14 | Human | Breast | DCIS | 4.96e-27 | 8.95e-01 | 0.2021 |
147179 | WIPF2 | DCIS2 | Human | Breast | DCIS | 3.75e-36 | 2.10e-01 | 0.0085 |
147179 | WIPF2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.02e-16 | 7.33e-01 | -0.1808 |
147179 | WIPF2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.25e-05 | 5.78e-01 | -0.0811 |
147179 | WIPF2 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.95e-04 | 4.08e-01 | -0.1088 |
147179 | WIPF2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-25 | 8.66e-01 | -0.1954 |
147179 | WIPF2 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.31e-08 | 1.07e+00 | -0.2602 |
147179 | WIPF2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.78e-05 | 5.39e-01 | -0.1207 |
147179 | WIPF2 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.60e-04 | 4.74e-01 | -0.1526 |
147179 | WIPF2 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.35e-10 | 6.54e-01 | -0.1464 |
147179 | WIPF2 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.70e-03 | 3.38e-01 | -0.1001 |
147179 | WIPF2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.07e-13 | 6.73e-01 | -0.059 |
147179 | WIPF2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.15e-03 | 7.17e-01 | -0.2061 |
147179 | WIPF2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.50e-03 | 6.00e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0030048 | Colorectum | AD | actin filament-based movement | 44/3918 | 127/18723 | 2.31e-04 | 2.99e-03 | 44 |
GO:00300481 | Colorectum | SER | actin filament-based movement | 38/2897 | 127/18723 | 2.80e-05 | 7.56e-04 | 38 |
GO:00300482 | Colorectum | MSS | actin filament-based movement | 44/3467 | 127/18723 | 1.11e-05 | 2.64e-04 | 44 |
GO:00300483 | Colorectum | FAP | actin filament-based movement | 44/2622 | 127/18723 | 3.48e-09 | 5.93e-07 | 44 |
GO:00300484 | Colorectum | CRC | actin filament-based movement | 42/2078 | 127/18723 | 2.96e-11 | 1.97e-08 | 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0513043 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0414416 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa0513053 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0414417 | Breast | DCIS | Endocytosis | 37/846 | 251/8465 | 9.92e-03 | 4.40e-02 | 3.24e-02 | 37 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05135 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051351 | Colorectum | AD | Yersinia infection | 58/2092 | 137/8465 | 3.90e-06 | 4.35e-05 | 2.78e-05 | 58 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa051352 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa051303 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa051353 | Colorectum | SER | Yersinia infection | 43/1580 | 137/8465 | 2.15e-04 | 2.10e-03 | 1.52e-03 | 43 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WIPF2 | SNV | Missense_Mutation | c.49C>T | p.Pro17Ser | p.P17S | Q8TF74 | protein_coding | deleterious_low_confidence(0.03) | probably_damaging(0.994) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
WIPF2 | insertion | In_Frame_Ins | novel | c.142_143insTCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCGATT | p.Thr48delinsIleSerAlaHisCysAsnLeuHisLeuLeuGlySerSerAspSer | p.T48delinsISAHCNLHLLGSSDS | Q8TF74 | protein_coding | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD | ||
WIPF2 | deletion | Frame_Shift_Del | novel | c.1269delC | p.Ser423ArgfsTer44 | p.S423Rfs*44 | Q8TF74 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
WIPF2 | SNV | Missense_Mutation | c.845N>A | p.Ser282Tyr | p.S282Y | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
WIPF2 | SNV | Missense_Mutation | novel | c.519N>A | p.Ser173Arg | p.S173R | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
WIPF2 | SNV | Missense_Mutation | c.238N>T | p.Ala80Ser | p.A80S | Q8TF74 | protein_coding | tolerated(0.41) | benign(0.029) | TCGA-AZ-4616-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | |
WIPF2 | SNV | Missense_Mutation | c.998G>A | p.Arg333Gln | p.R333Q | Q8TF74 | protein_coding | deleterious(0.03) | probably_damaging(0.953) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
WIPF2 | SNV | Missense_Mutation | c.1220A>G | p.Asp407Gly | p.D407G | Q8TF74 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-5341-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
WIPF2 | deletion | Frame_Shift_Del | c.613_616delNNNN | p.Glu206AsnfsTer31 | p.E206Nfs*31 | Q8TF74 | protein_coding | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
WIPF2 | deletion | Frame_Shift_Del | c.25delN | p.Pro10HisfsTer20 | p.P10Hfs*20 | Q8TF74 | protein_coding | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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