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Gene: WDR27 |
Gene summary for WDR27 |
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Gene information | Species | Human | Gene symbol | WDR27 | Gene ID | 253769 |
Gene name | WD repeat domain 27 | |
Gene Alias | WDR27 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A2RRH5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
253769 | WDR27 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.16e-14 | -4.36e-01 | 0.0155 |
253769 | WDR27 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.79e-06 | -4.81e-01 | -0.1808 |
253769 | WDR27 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.35e-08 | -4.29e-01 | -0.1088 |
253769 | WDR27 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.43e-06 | -3.98e-01 | -0.1464 |
253769 | WDR27 | HTA11_866_2000001011 | Human | Colorectum | AD | 8.78e-04 | -3.63e-01 | -0.1001 |
253769 | WDR27 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.17e-07 | -4.06e-01 | 0.096 |
253769 | WDR27 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.13e-03 | -3.41e-01 | 0.0338 |
253769 | WDR27 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.13e-04 | -3.25e-01 | 0.0674 |
253769 | WDR27 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.06e-02 | -3.35e-01 | 0.281 |
253769 | WDR27 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.43e-02 | -2.69e-01 | 0.3859 |
253769 | WDR27 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.70e-03 | -4.35e-01 | 0.2585 |
253769 | WDR27 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.74e-09 | -3.98e-01 | 0.3005 |
253769 | WDR27 | A001-C-207 | Human | Colorectum | FAP | 6.02e-04 | -1.61e-01 | 0.1278 |
253769 | WDR27 | A015-C-203 | Human | Colorectum | FAP | 1.47e-12 | -3.25e-01 | -0.1294 |
253769 | WDR27 | A015-C-204 | Human | Colorectum | FAP | 1.33e-04 | -1.61e-01 | -0.0228 |
253769 | WDR27 | A014-C-040 | Human | Colorectum | FAP | 2.28e-03 | -1.90e-01 | -0.1184 |
253769 | WDR27 | A002-C-201 | Human | Colorectum | FAP | 1.94e-12 | -2.40e-01 | 0.0324 |
253769 | WDR27 | A001-C-119 | Human | Colorectum | FAP | 4.95e-04 | -1.83e-01 | -0.1557 |
253769 | WDR27 | A001-C-108 | Human | Colorectum | FAP | 3.16e-04 | -1.30e-01 | -0.0272 |
253769 | WDR27 | A002-C-205 | Human | Colorectum | FAP | 5.71e-20 | -2.79e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR27 | SNV | Missense_Mutation | novel | c.1472N>T | p.Ser491Leu | p.S491L | A2RRH5 | protein_coding | tolerated(0.11) | benign(0.104) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
WDR27 | SNV | Missense_Mutation | c.412N>T | p.Val138Phe | p.V138F | A2RRH5 | protein_coding | deleterious(0) | possibly_damaging(0.595) | TCGA-D8-A1JM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine | SD | |
WDR27 | SNV | Missense_Mutation | novel | c.1618G>A | p.Ala540Thr | p.A540T | A2RRH5 | protein_coding | tolerated(0.29) | possibly_damaging(0.573) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR27 | SNV | Missense_Mutation | rs377380907 | c.1081G>A | p.Val361Ile | p.V361I | A2RRH5 | protein_coding | tolerated(1) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR27 | SNV | Missense_Mutation | novel | c.739N>A | p.Asp247Asn | p.D247N | A2RRH5 | protein_coding | tolerated(0.12) | benign(0.111) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WDR27 | SNV | Missense_Mutation | c.2211N>G | p.Ile737Met | p.I737M | A2RRH5 | protein_coding | deleterious(0) | benign(0.329) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR27 | SNV | Missense_Mutation | c.1745C>T | p.Ser582Leu | p.S582L | A2RRH5 | protein_coding | deleterious(0.04) | possibly_damaging(0.744) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
WDR27 | insertion | In_Frame_Ins | novel | c.50_51insATATTTTTCTCC | p.Asp17delinsGluTyrPheSerPro | p.D17delinsEYFSP | A2RRH5 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
WDR27 | SNV | Missense_Mutation | novel | c.1147A>C | p.Ile383Leu | p.I383L | A2RRH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.606) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
WDR27 | SNV | Missense_Mutation | rs370224643 | c.2465N>A | p.Arg822Gln | p.R822Q | A2RRH5 | protein_coding | deleterious(0.01) | possibly_damaging(0.806) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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