![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: UBR7 |
Gene summary for UBR7 |
![]() |
Gene information | Species | Human | Gene symbol | UBR7 | Gene ID | 55148 |
Gene name | ubiquitin protein ligase E3 component n-recognin 7 | |
Gene Alias | C14orf130 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N806 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55148 | UBR7 | LZE4T | Human | Esophagus | ESCC | 3.46e-06 | 2.46e-01 | 0.0811 |
55148 | UBR7 | LZE7T | Human | Esophagus | ESCC | 9.26e-04 | 1.78e-01 | 0.0667 |
55148 | UBR7 | LZE20T | Human | Esophagus | ESCC | 2.71e-06 | 1.22e-01 | 0.0662 |
55148 | UBR7 | LZE22T | Human | Esophagus | ESCC | 2.17e-03 | 3.10e-01 | 0.068 |
55148 | UBR7 | LZE24T | Human | Esophagus | ESCC | 1.13e-09 | 2.64e-01 | 0.0596 |
55148 | UBR7 | P1T-E | Human | Esophagus | ESCC | 2.60e-03 | 2.06e-01 | 0.0875 |
55148 | UBR7 | P2T-E | Human | Esophagus | ESCC | 7.00e-13 | 2.62e-01 | 0.1177 |
55148 | UBR7 | P4T-E | Human | Esophagus | ESCC | 2.99e-09 | 2.51e-01 | 0.1323 |
55148 | UBR7 | P5T-E | Human | Esophagus | ESCC | 3.04e-06 | 2.20e-01 | 0.1327 |
55148 | UBR7 | P8T-E | Human | Esophagus | ESCC | 7.77e-16 | 2.50e-01 | 0.0889 |
55148 | UBR7 | P9T-E | Human | Esophagus | ESCC | 3.50e-03 | 2.69e-02 | 0.1131 |
55148 | UBR7 | P10T-E | Human | Esophagus | ESCC | 8.78e-31 | 5.88e-01 | 0.116 |
55148 | UBR7 | P11T-E | Human | Esophagus | ESCC | 7.84e-08 | 4.49e-01 | 0.1426 |
55148 | UBR7 | P12T-E | Human | Esophagus | ESCC | 3.23e-24 | 4.80e-01 | 0.1122 |
55148 | UBR7 | P15T-E | Human | Esophagus | ESCC | 7.77e-19 | 4.99e-01 | 0.1149 |
55148 | UBR7 | P16T-E | Human | Esophagus | ESCC | 5.07e-18 | 3.80e-01 | 0.1153 |
55148 | UBR7 | P17T-E | Human | Esophagus | ESCC | 2.38e-04 | 2.01e-01 | 0.1278 |
55148 | UBR7 | P19T-E | Human | Esophagus | ESCC | 2.68e-02 | 3.81e-01 | 0.1662 |
55148 | UBR7 | P20T-E | Human | Esophagus | ESCC | 1.19e-13 | 3.21e-01 | 0.1124 |
55148 | UBR7 | P21T-E | Human | Esophagus | ESCC | 1.79e-08 | 1.98e-01 | 0.1617 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UBR7 | SNV | Missense_Mutation | novel | c.1144G>A | p.Glu382Lys | p.E382K | Q8N806 | protein_coding | deleterious(0.03) | benign(0.186) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
UBR7 | SNV | Missense_Mutation | rs267604099 | c.292N>T | p.Arg98Cys | p.R98C | Q8N806 | protein_coding | tolerated(0.06) | probably_damaging(0.957) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
UBR7 | SNV | Missense_Mutation | novel | c.772N>A | p.Glu258Lys | p.E258K | Q8N806 | protein_coding | tolerated(0.14) | benign(0.009) | TCGA-E2-A1IU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
UBR7 | deletion | Frame_Shift_Del | c.990delN | p.Leu331Ter | p.L331* | Q8N806 | protein_coding | TCGA-E2-A14T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |||
UBR7 | SNV | Missense_Mutation | novel | c.169N>T | p.Ala57Ser | p.A57S | Q8N806 | protein_coding | deleterious(0.03) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UBR7 | SNV | Missense_Mutation | novel | c.800N>G | p.Ser267Cys | p.S267C | Q8N806 | protein_coding | tolerated(0.16) | benign(0.353) | TCGA-VS-A9V1-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
UBR7 | SNV | Missense_Mutation | novel | c.1273N>G | p.Ser425Gly | p.S425G | Q8N806 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.746) | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
UBR7 | insertion | Nonsense_Mutation | novel | c.1111_1112insCTCTGGAGTGTGTCT | p.Glu371delinsAlaLeuGluCysValTer | p.E371delinsALECV* | Q8N806 | protein_coding | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | ||
UBR7 | SNV | Missense_Mutation | c.470T>A | p.Val157Asp | p.V157D | Q8N806 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
UBR7 | SNV | Missense_Mutation | rs372446489 | c.638G>A | p.Arg213Gln | p.R213Q | Q8N806 | protein_coding | tolerated(0.58) | benign(0) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |