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Gene: TRMT12 |
Gene summary for TRMT12 |
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Gene information | Species | Human | Gene symbol | TRMT12 | Gene ID | 55039 |
Gene name | tRNA methyltransferase 12 homolog | |
Gene Alias | TRM12 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | Q53H54 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55039 | TRMT12 | LZE4T | Human | Esophagus | ESCC | 5.83e-04 | 1.32e-01 | 0.0811 |
55039 | TRMT12 | LZE20T | Human | Esophagus | ESCC | 2.75e-02 | 1.55e-01 | 0.0662 |
55039 | TRMT12 | LZE24T | Human | Esophagus | ESCC | 5.37e-04 | 1.99e-01 | 0.0596 |
55039 | TRMT12 | P2T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.78e-01 | 0.1177 |
55039 | TRMT12 | P4T-E | Human | Esophagus | ESCC | 1.53e-09 | 1.50e-01 | 0.1323 |
55039 | TRMT12 | P5T-E | Human | Esophagus | ESCC | 2.72e-06 | 9.67e-02 | 0.1327 |
55039 | TRMT12 | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 6.99e-02 | 0.0889 |
55039 | TRMT12 | P9T-E | Human | Esophagus | ESCC | 1.13e-03 | 8.78e-02 | 0.1131 |
55039 | TRMT12 | P10T-E | Human | Esophagus | ESCC | 1.12e-11 | 1.29e-01 | 0.116 |
55039 | TRMT12 | P11T-E | Human | Esophagus | ESCC | 2.70e-05 | 2.74e-01 | 0.1426 |
55039 | TRMT12 | P12T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.78e-01 | 0.1122 |
55039 | TRMT12 | P15T-E | Human | Esophagus | ESCC | 4.35e-15 | 3.11e-01 | 0.1149 |
55039 | TRMT12 | P16T-E | Human | Esophagus | ESCC | 6.56e-15 | 2.89e-01 | 0.1153 |
55039 | TRMT12 | P17T-E | Human | Esophagus | ESCC | 1.59e-02 | 2.02e-01 | 0.1278 |
55039 | TRMT12 | P20T-E | Human | Esophagus | ESCC | 1.35e-03 | 1.33e-01 | 0.1124 |
55039 | TRMT12 | P21T-E | Human | Esophagus | ESCC | 1.30e-15 | 2.79e-01 | 0.1617 |
55039 | TRMT12 | P22T-E | Human | Esophagus | ESCC | 1.88e-11 | 1.90e-01 | 0.1236 |
55039 | TRMT12 | P23T-E | Human | Esophagus | ESCC | 6.01e-12 | 2.70e-01 | 0.108 |
55039 | TRMT12 | P24T-E | Human | Esophagus | ESCC | 4.12e-11 | 1.94e-01 | 0.1287 |
55039 | TRMT12 | P26T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.44e-01 | 0.1276 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
GO:0030488 | Liver | HCC | tRNA methylation | 29/7958 | 41/18723 | 2.38e-04 | 1.79e-03 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRMT12 | SNV | Missense_Mutation | c.599A>T | p.Glu200Val | p.E200V | Q53H54 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TRMT12 | SNV | Missense_Mutation | c.1163N>G | p.Thr388Ser | p.T388S | Q53H54 | protein_coding | tolerated(0.78) | benign(0) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TRMT12 | insertion | Nonsense_Mutation | novel | c.679_680insATTTACTACCAGTTTCTGTCTGACCCAGTCAGACATCT | p.Arg227HisfsTer8 | p.R227Hfs*8 | Q53H54 | protein_coding | TCGA-A2-A0ER-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
TRMT12 | insertion | In_Frame_Ins | novel | c.1034_1035insGCT | p.Lys345_Asn346insLeu | p.K345_N346insL | Q53H54 | protein_coding | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRMT12 | insertion | Frame_Shift_Ins | novel | c.1036_1037insAGCTCTCAAATATTGCAGATAGGGTG | p.Asn346LysfsTer19 | p.N346Kfs*19 | Q53H54 | protein_coding | TCGA-A8-A081-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TRMT12 | insertion | Frame_Shift_Ins | novel | c.1081_1082insCCAGGGTTGTTCACCTGCCCAAAAAT | p.Leu361ProfsTer74 | p.L361Pfs*74 | Q53H54 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
TRMT12 | SNV | Missense_Mutation | novel | c.76N>C | p.Glu26Gln | p.E26Q | Q53H54 | protein_coding | tolerated(0.07) | probably_damaging(0.946) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
TRMT12 | SNV | Missense_Mutation | c.884G>T | p.Arg295Ile | p.R295I | Q53H54 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
TRMT12 | SNV | Missense_Mutation | c.1210G>A | p.Ala404Thr | p.A404T | Q53H54 | protein_coding | tolerated(0.42) | benign(0.015) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
TRMT12 | SNV | Missense_Mutation | c.965G>A | p.Cys322Tyr | p.C322Y | Q53H54 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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