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Gene: TMEM167B |
Gene summary for TMEM167B |
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Gene information | Species | Human | Gene symbol | TMEM167B | Gene ID | 56900 |
Gene name | transmembrane protein 167B | |
Gene Alias | AD-020 | |
Cytomap | 1p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q9NRX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56900 | TMEM167B | LZE4T | Human | Esophagus | ESCC | 2.10e-17 | 4.00e-01 | 0.0811 |
56900 | TMEM167B | LZE5T | Human | Esophagus | ESCC | 2.14e-03 | 9.48e-02 | 0.0514 |
56900 | TMEM167B | LZE7T | Human | Esophagus | ESCC | 2.88e-05 | 4.60e-02 | 0.0667 |
56900 | TMEM167B | LZE20T | Human | Esophagus | ESCC | 3.36e-11 | 2.24e-01 | 0.0662 |
56900 | TMEM167B | LZE24T | Human | Esophagus | ESCC | 1.37e-15 | 3.32e-01 | 0.0596 |
56900 | TMEM167B | LZE6T | Human | Esophagus | ESCC | 3.41e-07 | 1.87e-02 | 0.0845 |
56900 | TMEM167B | P1T-E | Human | Esophagus | ESCC | 7.72e-08 | 4.29e-01 | 0.0875 |
56900 | TMEM167B | P2T-E | Human | Esophagus | ESCC | 8.33e-16 | 2.54e-01 | 0.1177 |
56900 | TMEM167B | P4T-E | Human | Esophagus | ESCC | 2.46e-15 | 2.90e-01 | 0.1323 |
56900 | TMEM167B | P5T-E | Human | Esophagus | ESCC | 9.55e-20 | 4.20e-01 | 0.1327 |
56900 | TMEM167B | P8T-E | Human | Esophagus | ESCC | 2.04e-17 | 2.50e-01 | 0.0889 |
56900 | TMEM167B | P9T-E | Human | Esophagus | ESCC | 9.36e-21 | 4.12e-01 | 0.1131 |
56900 | TMEM167B | P10T-E | Human | Esophagus | ESCC | 1.02e-26 | 3.53e-01 | 0.116 |
56900 | TMEM167B | P11T-E | Human | Esophagus | ESCC | 9.34e-19 | 2.43e-01 | 0.1426 |
56900 | TMEM167B | P12T-E | Human | Esophagus | ESCC | 2.09e-40 | 7.26e-01 | 0.1122 |
56900 | TMEM167B | P15T-E | Human | Esophagus | ESCC | 4.95e-14 | 2.63e-01 | 0.1149 |
56900 | TMEM167B | P16T-E | Human | Esophagus | ESCC | 2.49e-17 | 1.39e-01 | 0.1153 |
56900 | TMEM167B | P17T-E | Human | Esophagus | ESCC | 5.63e-10 | 2.30e-01 | 0.1278 |
56900 | TMEM167B | P19T-E | Human | Esophagus | ESCC | 1.78e-03 | 2.49e-01 | 0.1662 |
56900 | TMEM167B | P20T-E | Human | Esophagus | ESCC | 4.14e-16 | 3.62e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM167B | SNV | Missense_Mutation | novel | c.168N>G | p.His56Gln | p.H56Q | Q9NRX6 | protein_coding | tolerated(0.09) | benign(0.357) | TCGA-BH-A0DK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TMEM167B | SNV | Missense_Mutation | novel | c.187N>C | p.Cys63Arg | p.C63R | Q9NRX6 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM167B | SNV | Missense_Mutation | novel | c.220N>C | p.Lys74Gln | p.K74Q | Q9NRX6 | protein_coding | tolerated(0.58) | benign(0.063) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMEM167B | SNV | Missense_Mutation | c.145G>T | p.Ala49Ser | p.A49S | Q9NRX6 | protein_coding | tolerated(0.25) | benign(0.022) | TCGA-CH-5766-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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