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Gene: TMEM163 |
Gene summary for TMEM163 |
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Gene information | Species | Human | Gene symbol | TMEM163 | Gene ID | 81615 |
Gene name | transmembrane protein 163 | |
Gene Alias | DC29 | |
Cytomap | 2q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000041 | UniProtAcc | Q8TC26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81615 | TMEM163 | RNA-P10T2-P10T2-1 | Human | Lung | AAH | 1.81e-02 | 6.49e-01 | -0.1271 |
81615 | TMEM163 | RNA-P10T2-P10T2-3 | Human | Lung | AAH | 3.80e-05 | 8.09e-01 | -0.1408 |
81615 | TMEM163 | RNA-P10T2-P10T2-4 | Human | Lung | AAH | 2.01e-04 | 6.02e-01 | -0.138 |
81615 | TMEM163 | RNA-P23T2-P23T2-2 | Human | Lung | MIAC | 5.81e-03 | 9.57e-01 | -0.028 |
81615 | TMEM163 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 8.89e-25 | 1.07e+00 | -0.2116 |
81615 | TMEM163 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 4.36e-09 | 1.01e+00 | -0.1941 |
81615 | TMEM163 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 3.09e-16 | 1.20e+00 | -0.2107 |
81615 | TMEM163 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 5.07e-15 | 1.03e+00 | -0.2119 |
81615 | TMEM163 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.68e-07 | 8.98e-01 | 0.1829 |
81615 | TMEM163 | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.09e-09 | 9.19e-01 | 0.1835 |
81615 | TMEM163 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.94e-09 | 8.74e-01 | 0.1859 |
81615 | TMEM163 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 7.24e-64 | 1.46e+00 | -0.0166 |
81615 | TMEM163 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 3.03e-69 | 1.50e+00 | -0.0132 |
81615 | TMEM163 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 2.22e-71 | 1.51e+00 | -0.013 |
81615 | TMEM163 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 4.10e-75 | 1.54e+00 | -0.0121 |
81615 | TMEM163 | RNA-P7T1-P7T1-1 | Human | Lung | AIS | 2.36e-11 | 9.78e-01 | -0.0961 |
81615 | TMEM163 | RNA-P7T1-P7T1-2 | Human | Lung | AIS | 2.39e-09 | 8.80e-01 | -0.0876 |
81615 | TMEM163 | RNA-P7T1-P7T1-3 | Human | Lung | AIS | 3.12e-07 | 9.72e-01 | -0.0822 |
81615 | TMEM163 | RNA-P7T1-P7T1-4 | Human | Lung | AIS | 4.79e-09 | 9.17e-01 | -0.0809 |
81615 | TMEM163 | HTA12-23-1 | Human | Pancreas | PDAC | 1.89e-09 | 1.12e+00 | 0.3405 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM163 | SNV | Missense_Mutation | c.238N>A | p.Glu80Lys | p.E80K | Q8TC26 | protein_coding | tolerated(0.2) | probably_damaging(0.992) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM163 | SNV | Missense_Mutation | c.301G>C | p.Ala101Pro | p.A101P | Q8TC26 | protein_coding | tolerated(0.09) | probably_damaging(0.919) | TCGA-AN-A0FV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM163 | SNV | Missense_Mutation | c.636N>T | p.Lys212Asn | p.K212N | Q8TC26 | protein_coding | tolerated(0.06) | benign(0.013) | TCGA-C5-A1ME-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
TMEM163 | deletion | Frame_Shift_Del | c.470delN | p.Ile157ThrfsTer4 | p.I157Tfs*4 | Q8TC26 | protein_coding | TCGA-ZJ-AAXF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
TMEM163 | SNV | Missense_Mutation | rs755523021 | c.331G>A | p.Val111Ile | p.V111I | Q8TC26 | protein_coding | tolerated(0.63) | benign(0.05) | TCGA-A6-5656-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TMEM163 | SNV | Missense_Mutation | c.782N>A | p.Gly261Asp | p.G261D | Q8TC26 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
TMEM163 | SNV | Missense_Mutation | c.244C>A | p.Gln82Lys | p.Q82K | Q8TC26 | protein_coding | deleterious(0.03) | probably_damaging(0.968) | TCGA-AA-3844-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | |
TMEM163 | SNV | Missense_Mutation | rs376678158 | c.719N>T | p.Ala240Val | p.A240V | Q8TC26 | protein_coding | tolerated(0.08) | probably_damaging(0.991) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TMEM163 | SNV | Missense_Mutation | c.412N>T | p.Arg138Cys | p.R138C | Q8TC26 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
TMEM163 | SNV | Missense_Mutation | c.413N>A | p.Arg138His | p.R138H | Q8TC26 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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