![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMEM128 |
Gene summary for TMEM128 |
![]() |
Gene information | Species | Human | Gene symbol | TMEM128 | Gene ID | 85013 |
Gene name | transmembrane protein 128 | |
Gene Alias | TMEM128 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | B7Z3K1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
85013 | TMEM128 | LZE7T | Human | Esophagus | ESCC | 4.18e-06 | 5.64e-01 | 0.0667 |
85013 | TMEM128 | LZE20T | Human | Esophagus | ESCC | 1.29e-04 | 1.47e-01 | 0.0662 |
85013 | TMEM128 | LZE24T | Human | Esophagus | ESCC | 4.19e-06 | 2.60e-01 | 0.0596 |
85013 | TMEM128 | P1T-E | Human | Esophagus | ESCC | 3.67e-04 | 1.40e-01 | 0.0875 |
85013 | TMEM128 | P2T-E | Human | Esophagus | ESCC | 1.11e-26 | 5.38e-01 | 0.1177 |
85013 | TMEM128 | P4T-E | Human | Esophagus | ESCC | 1.81e-14 | 2.87e-01 | 0.1323 |
85013 | TMEM128 | P5T-E | Human | Esophagus | ESCC | 1.06e-08 | 1.94e-01 | 0.1327 |
85013 | TMEM128 | P8T-E | Human | Esophagus | ESCC | 2.72e-26 | 4.72e-01 | 0.0889 |
85013 | TMEM128 | P10T-E | Human | Esophagus | ESCC | 3.17e-11 | 2.02e-01 | 0.116 |
85013 | TMEM128 | P11T-E | Human | Esophagus | ESCC | 3.39e-02 | 1.70e-01 | 0.1426 |
85013 | TMEM128 | P12T-E | Human | Esophagus | ESCC | 1.23e-33 | 5.23e-01 | 0.1122 |
85013 | TMEM128 | P15T-E | Human | Esophagus | ESCC | 2.93e-07 | 1.86e-01 | 0.1149 |
85013 | TMEM128 | P16T-E | Human | Esophagus | ESCC | 2.40e-39 | 6.28e-01 | 0.1153 |
85013 | TMEM128 | P17T-E | Human | Esophagus | ESCC | 4.01e-06 | 1.56e-01 | 0.1278 |
85013 | TMEM128 | P19T-E | Human | Esophagus | ESCC | 3.61e-02 | 1.68e-01 | 0.1662 |
85013 | TMEM128 | P20T-E | Human | Esophagus | ESCC | 2.53e-11 | 2.03e-01 | 0.1124 |
85013 | TMEM128 | P21T-E | Human | Esophagus | ESCC | 4.38e-18 | 2.06e-01 | 0.1617 |
85013 | TMEM128 | P22T-E | Human | Esophagus | ESCC | 3.89e-08 | 7.50e-02 | 0.1236 |
85013 | TMEM128 | P23T-E | Human | Esophagus | ESCC | 8.39e-05 | 1.46e-01 | 0.108 |
85013 | TMEM128 | P24T-E | Human | Esophagus | ESCC | 6.00e-10 | 1.32e-01 | 0.1287 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMEM128 | deletion | Frame_Shift_Del | novel | c.214delN | p.Glu74LysfsTer27 | p.E74Kfs*27 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |||
TMEM128 | SNV | Missense_Mutation | novel | c.127A>G | p.Lys43Glu | p.K43E | protein_coding | tolerated(0.08) | benign(0.359) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TMEM128 | SNV | Missense_Mutation | c.269N>A | p.Leu90His | p.L90H | protein_coding | tolerated(0.55) | possibly_damaging(0.8) | TCGA-AA-A02J-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | ||
TMEM128 | insertion | Frame_Shift_Ins | novel | c.122_123insA | p.Glu42GlyfsTer8 | p.E42Gfs*8 | protein_coding | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
TMEM128 | SNV | Missense_Mutation | rs138483289 | c.404N>G | p.Asn135Ser | p.N135S | protein_coding | deleterious(0.02) | probably_damaging(0.994) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
TMEM128 | SNV | Missense_Mutation | novel | c.286G>A | p.Ala96Thr | p.A96T | protein_coding | deleterious(0) | possibly_damaging(0.586) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
TMEM128 | SNV | Missense_Mutation | novel | c.466N>A | p.Gly156Arg | p.G156R | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM128 | SNV | Missense_Mutation | c.481A>T | p.Ile161Phe | p.I161F | protein_coding | deleterious(0) | possibly_damaging(0.555) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TMEM128 | SNV | Missense_Mutation | novel | c.172N>A | p.Ala58Thr | p.A58T | protein_coding | deleterious(0.04) | benign(0.043) | TCGA-EO-A3AZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TMEM128 | SNV | Missense_Mutation | rs759483260 | c.376N>C | p.Ser126Pro | p.S126P | protein_coding | deleterious(0.01) | benign(0.014) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |