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Gene: SUMF2 |
Gene summary for SUMF2 |
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Gene information | Species | Human | Gene symbol | SUMF2 | Gene ID | 25870 |
Gene name | sulfatase modifying factor 2 | |
Gene Alias | pFGE | |
Cytomap | 7p11.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q8NBJ7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25870 | SUMF2 | LZE4T | Human | Esophagus | ESCC | 9.17e-12 | 4.01e-01 | 0.0811 |
25870 | SUMF2 | LZE5T | Human | Esophagus | ESCC | 5.18e-03 | 5.79e-01 | 0.0514 |
25870 | SUMF2 | LZE7T | Human | Esophagus | ESCC | 1.07e-07 | 3.39e-01 | 0.0667 |
25870 | SUMF2 | LZE8T | Human | Esophagus | ESCC | 6.66e-12 | 3.96e-01 | 0.067 |
25870 | SUMF2 | LZE20T | Human | Esophagus | ESCC | 9.31e-13 | 6.34e-01 | 0.0662 |
25870 | SUMF2 | LZE22D1 | Human | Esophagus | HGIN | 5.96e-06 | 2.72e-01 | 0.0595 |
25870 | SUMF2 | LZE22T | Human | Esophagus | ESCC | 1.27e-04 | 6.60e-01 | 0.068 |
25870 | SUMF2 | LZE24T | Human | Esophagus | ESCC | 4.22e-18 | 6.19e-01 | 0.0596 |
25870 | SUMF2 | LZE21T | Human | Esophagus | ESCC | 3.46e-03 | 5.37e-01 | 0.0655 |
25870 | SUMF2 | LZE6T | Human | Esophagus | ESCC | 4.42e-09 | 4.42e-01 | 0.0845 |
25870 | SUMF2 | P1T-E | Human | Esophagus | ESCC | 1.18e-12 | 7.61e-01 | 0.0875 |
25870 | SUMF2 | P2T-E | Human | Esophagus | ESCC | 4.59e-38 | 7.67e-01 | 0.1177 |
25870 | SUMF2 | P4T-E | Human | Esophagus | ESCC | 2.40e-46 | 1.09e+00 | 0.1323 |
25870 | SUMF2 | P5T-E | Human | Esophagus | ESCC | 1.19e-11 | 2.53e-01 | 0.1327 |
25870 | SUMF2 | P8T-E | Human | Esophagus | ESCC | 4.04e-35 | 6.08e-01 | 0.0889 |
25870 | SUMF2 | P9T-E | Human | Esophagus | ESCC | 1.58e-28 | 6.84e-01 | 0.1131 |
25870 | SUMF2 | P10T-E | Human | Esophagus | ESCC | 5.26e-70 | 1.14e+00 | 0.116 |
25870 | SUMF2 | P11T-E | Human | Esophagus | ESCC | 3.13e-18 | 6.10e-01 | 0.1426 |
25870 | SUMF2 | P12T-E | Human | Esophagus | ESCC | 9.83e-43 | 8.69e-01 | 0.1122 |
25870 | SUMF2 | P15T-E | Human | Esophagus | ESCC | 7.27e-30 | 7.39e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SUMF2 | SNV | Missense_Mutation | novel | c.107N>A | p.Gly36Asp | p.G36D | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.999) | TCGA-5L-AAT0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
SUMF2 | SNV | Missense_Mutation | rs150976522 | c.220C>T | p.Arg74Trp | p.R74W | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.614) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SUMF2 | SNV | Missense_Mutation | c.895N>G | p.Pro299Ala | p.P299A | protein_coding | tolerated_low_confidence(0.13) | benign(0.115) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
SUMF2 | SNV | Missense_Mutation | rs377488706 | c.149T>C | p.Val50Ala | p.V50A | protein_coding | tolerated_low_confidence(0.05) | possibly_damaging(0.648) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
SUMF2 | SNV | Missense_Mutation | rs778778455 | c.770N>T | p.Ser257Leu | p.S257L | protein_coding | tolerated_low_confidence(0.06) | benign(0) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
SUMF2 | SNV | Missense_Mutation | rs529975935 | c.803G>A | p.Arg268His | p.R268H | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SUMF2 | SNV | Missense_Mutation | c.571G>A | p.Ala191Thr | p.A191T | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | ||
SUMF2 | SNV | Missense_Mutation | c.536G>T | p.Gly179Val | p.G179V | protein_coding | deleterious(0) | probably_damaging(0.933) | TCGA-AJ-A23M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | unknown | PD | ||
SUMF2 | SNV | Missense_Mutation | novel | c.663N>T | p.Lys221Asn | p.K221N | protein_coding | tolerated(0.17) | benign(0.255) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR | |
SUMF2 | SNV | Missense_Mutation | c.211N>T | p.Gly71Trp | p.G71W | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.996) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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