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Gene: SPRING1 |
Gene summary for SPRING1 |
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Gene information | Species | Human | Gene symbol | SPRING1 | Gene ID | 79794 |
Gene name | SREBF pathway regulator in golgi 1 | |
Gene Alias | C12orf49 | |
Cytomap | 12q24.22 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | A0A024RBQ8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79794 | SPRING1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.30e-05 | 1.28e-01 | 0.0155 |
79794 | SPRING1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.60e-12 | 3.40e-01 | -0.1808 |
79794 | SPRING1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.43e-08 | 2.87e-01 | -0.0811 |
79794 | SPRING1 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.20e-06 | 2.34e-01 | -0.1088 |
79794 | SPRING1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.04e-25 | 4.23e-01 | -0.1954 |
79794 | SPRING1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.20e-07 | 5.69e-01 | -0.2602 |
79794 | SPRING1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 2.44e-01 | -0.2196 |
79794 | SPRING1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.26e-04 | 2.02e-01 | -0.1207 |
79794 | SPRING1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.47e-06 | 2.58e-01 | -0.1526 |
79794 | SPRING1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.82e-13 | 2.54e-01 | -0.1464 |
79794 | SPRING1 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.55e-09 | 2.01e-01 | -0.1001 |
79794 | SPRING1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.44e-15 | 3.71e-01 | -0.059 |
79794 | SPRING1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.51e-04 | 2.63e-01 | -0.1706 |
79794 | SPRING1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.44e-09 | 3.82e-01 | -0.2061 |
79794 | SPRING1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.52e-01 | -0.1462 |
79794 | SPRING1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 7.36e-06 | 2.34e-01 | -0.0179 |
79794 | SPRING1 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.35e-11 | 2.55e-01 | 0.096 |
79794 | SPRING1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.37e-05 | 2.67e-01 | 0.0528 |
79794 | SPRING1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.29e-03 | 2.04e-01 | 0.0131 |
79794 | SPRING1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.46e-06 | 2.63e-01 | -0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006984 | Colorectum | AD | ER-nucleus signaling pathway | 21/3918 | 46/18723 | 1.47e-04 | 2.08e-03 | 21 |
GO:0032933 | Colorectum | AD | SREBP signaling pathway | 9/3918 | 15/18723 | 1.11e-03 | 1.01e-02 | 9 |
GO:0071501 | Colorectum | AD | cellular response to sterol depletion | 9/3918 | 16/18723 | 2.06e-03 | 1.64e-02 | 9 |
GO:0006991 | Colorectum | AD | response to sterol depletion | 9/3918 | 18/18723 | 5.82e-03 | 3.67e-02 | 9 |
GO:00069841 | Colorectum | SER | ER-nucleus signaling pathway | 15/2897 | 46/18723 | 2.92e-03 | 2.59e-02 | 15 |
GO:00329331 | Colorectum | SER | SREBP signaling pathway | 7/2897 | 15/18723 | 4.30e-03 | 3.45e-02 | 7 |
GO:00715011 | Colorectum | SER | cellular response to sterol depletion | 7/2897 | 16/18723 | 6.63e-03 | 4.69e-02 | 7 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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