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Gene: SLC66A2 |
Gene summary for SLC66A2 |
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Gene information | Species | Human | Gene symbol | SLC66A2 | Gene ID | 80148 |
Gene name | solute carrier family 66 member 2 | |
Gene Alias | PQLC1 | |
Cytomap | 18q23 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q8N2U9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80148 | SLC66A2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.98e-03 | 1.08e-01 | 0.0155 |
80148 | SLC66A2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.08e-14 | 3.48e-01 | -0.1808 |
80148 | SLC66A2 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.79e-07 | 3.89e-01 | 0.0216 |
80148 | SLC66A2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.73e-09 | 2.65e-01 | -0.0811 |
80148 | SLC66A2 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.42e-01 | -0.1088 |
80148 | SLC66A2 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.41e-38 | 6.19e-01 | -0.1954 |
80148 | SLC66A2 | HTA11_411_2000001011 | Human | Colorectum | SER | 6.89e-14 | 6.61e-01 | -0.2602 |
80148 | SLC66A2 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-05 | 5.59e-01 | -0.2196 |
80148 | SLC66A2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.74e-18 | 5.20e-01 | -0.1207 |
80148 | SLC66A2 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.95e-14 | 3.71e-01 | -0.1526 |
80148 | SLC66A2 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.84e-22 | 4.31e-01 | -0.1464 |
80148 | SLC66A2 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.10e-17 | 3.27e-01 | -0.1001 |
80148 | SLC66A2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.60e-11 | 2.91e-01 | -0.059 |
80148 | SLC66A2 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.54e-11 | 5.26e-01 | -0.1706 |
80148 | SLC66A2 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.16e-07 | 3.42e-01 | -0.2061 |
80148 | SLC66A2 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.84e-10 | 4.90e-01 | -0.1462 |
80148 | SLC66A2 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.56e-06 | 3.04e-01 | -0.0842 |
80148 | SLC66A2 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.01e-04 | 3.68e-01 | -0.00410000000000005 |
80148 | SLC66A2 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.67e-07 | 3.22e-01 | -0.0179 |
80148 | SLC66A2 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-16 | 3.50e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0016482 | Colorectum | AD | cytosolic transport | 68/3918 | 168/18723 | 6.00e-09 | 3.72e-07 | 68 |
GO:0042147 | Colorectum | AD | retrograde transport, endosome to Golgi | 37/3918 | 91/18723 | 1.46e-05 | 3.14e-04 | 37 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0015748 | Colorectum | AD | organophosphate ester transport | 42/3918 | 140/18723 | 7.04e-03 | 4.31e-02 | 42 |
GO:00161971 | Colorectum | SER | endosomal transport | 61/2897 | 230/18723 | 1.03e-05 | 3.35e-04 | 61 |
GO:00164821 | Colorectum | SER | cytosolic transport | 46/2897 | 168/18723 | 5.20e-05 | 1.25e-03 | 46 |
GO:001648215 | Skin | AK | cytosolic transport | 36/1910 | 168/18723 | 1.26e-05 | 2.56e-04 | 36 |
GO:001619716 | Skin | AK | endosomal transport | 41/1910 | 230/18723 | 2.76e-04 | 2.93e-03 | 41 |
GO:00421478 | Skin | AK | retrograde transport, endosome to Golgi | 19/1910 | 91/18723 | 1.84e-03 | 1.27e-02 | 19 |
GO:001619717 | Skin | cSCC | endosomal transport | 98/4864 | 230/18723 | 2.71e-08 | 7.41e-07 | 98 |
GO:001648216 | Skin | cSCC | cytosolic transport | 71/4864 | 168/18723 | 3.02e-06 | 4.72e-05 | 71 |
GO:004214714 | Skin | cSCC | retrograde transport, endosome to Golgi | 40/4864 | 91/18723 | 1.49e-04 | 1.33e-03 | 40 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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