![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SLC17A4 |
Gene summary for SLC17A4 |
![]() |
Gene information | Species | Human | Gene symbol | SLC17A4 | Gene ID | 10050 |
Gene name | solute carrier family 17 member 4 | |
Gene Alias | KAIA2138 | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006793 | UniProtAcc | Q9Y2C5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10050 | SLC17A4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.22e-07 | 3.78e-01 | -0.1808 |
10050 | SLC17A4 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.34e-02 | 1.93e-01 | -0.1088 |
10050 | SLC17A4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.78e-16 | 5.64e-01 | -0.1954 |
10050 | SLC17A4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.57e-04 | 5.25e-01 | -0.2196 |
10050 | SLC17A4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.48e-02 | 3.56e-01 | -0.2061 |
10050 | SLC17A4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 4.76e-11 | 3.81e-01 | 0.3005 |
Page: 1 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC17A4 | SNV | Missense_Mutation | novel | c.664N>T | p.Leu222Phe | p.L222F | Q9Y2C5 | protein_coding | deleterious(0) | possibly_damaging(0.844) | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC17A4 | SNV | Missense_Mutation | c.659G>C | p.Gly220Ala | p.G220A | Q9Y2C5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-C8-A12Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
SLC17A4 | SNV | Missense_Mutation | novel | c.1101G>T | p.Arg367Ser | p.R367S | Q9Y2C5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SLC17A4 | insertion | In_Frame_Ins | novel | c.1252_1253insATGAACATATACATACTAAAAGTATATTGGCTCATTATAGTAACA | p.Leu418delinsTyrGluHisIleHisThrLysSerIleLeuAlaHisTyrSerAsnMet | p.L418delinsYEHIHTKSILAHYSNM | Q9Y2C5 | protein_coding | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
SLC17A4 | insertion | Frame_Shift_Ins | novel | c.890_891insACAAC | p.Leu298GlnfsTer3 | p.L298Qfs*3 | Q9Y2C5 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
SLC17A4 | insertion | In_Frame_Ins | novel | c.890_891insACAACTTGC | p.Ile297_Leu298insGlnLeuAla | p.I297_L298insQLA | Q9Y2C5 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | insertion | In_Frame_Ins | novel | c.1304_1305insCATATATAATCC | p.Phe435_Ala436insIleTyrAsnPro | p.F435_A436insIYNP | Q9Y2C5 | protein_coding | TCGA-B6-A0I8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | ||
SLC17A4 | insertion | Nonsense_Mutation | novel | c.774_775insGGAGGGATGCTGACTGGTACGTGAA | p.Phe259GlyfsTer8 | p.F259Gfs*8 | Q9Y2C5 | protein_coding | TCGA-B6-A0IM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SLC17A4 | SNV | Missense_Mutation | novel | c.1208N>T | p.Ser403Phe | p.S403F | Q9Y2C5 | protein_coding | tolerated(0.54) | benign(0.033) | TCGA-C5-A1MF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC17A4 | SNV | Missense_Mutation | c.923N>G | p.Phe308Cys | p.F308C | Q9Y2C5 | protein_coding | tolerated(0.41) | benign(0.053) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |