![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SHISA4 |
Gene summary for SHISA4 |
![]() |
Gene information | Species | Human | Gene symbol | SHISA4 | Gene ID | 149345 |
Gene name | shisa family member 4 | |
Gene Alias | C1orf40 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96DD7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
149345 | SHISA4 | LZE4T | Human | Esophagus | ESCC | 1.83e-10 | 3.12e-01 | 0.0811 |
149345 | SHISA4 | P2T-E | Human | Esophagus | ESCC | 4.80e-15 | 2.93e-01 | 0.1177 |
149345 | SHISA4 | P4T-E | Human | Esophagus | ESCC | 5.54e-30 | 7.09e-01 | 0.1323 |
149345 | SHISA4 | P8T-E | Human | Esophagus | ESCC | 1.69e-08 | 2.19e-01 | 0.0889 |
149345 | SHISA4 | P9T-E | Human | Esophagus | ESCC | 1.43e-12 | 4.12e-01 | 0.1131 |
149345 | SHISA4 | P10T-E | Human | Esophagus | ESCC | 2.81e-31 | 6.44e-01 | 0.116 |
149345 | SHISA4 | P11T-E | Human | Esophagus | ESCC | 7.60e-19 | 6.71e-01 | 0.1426 |
149345 | SHISA4 | P16T-E | Human | Esophagus | ESCC | 1.14e-45 | 7.76e-01 | 0.1153 |
149345 | SHISA4 | P17T-E | Human | Esophagus | ESCC | 1.98e-04 | 2.15e-01 | 0.1278 |
149345 | SHISA4 | P19T-E | Human | Esophagus | ESCC | 1.12e-11 | 6.00e-01 | 0.1662 |
149345 | SHISA4 | P21T-E | Human | Esophagus | ESCC | 8.50e-04 | 1.67e-01 | 0.1617 |
149345 | SHISA4 | P22T-E | Human | Esophagus | ESCC | 1.07e-27 | 5.29e-01 | 0.1236 |
149345 | SHISA4 | P24T-E | Human | Esophagus | ESCC | 6.40e-16 | 4.20e-01 | 0.1287 |
149345 | SHISA4 | P26T-E | Human | Esophagus | ESCC | 8.37e-16 | 4.06e-01 | 0.1276 |
149345 | SHISA4 | P28T-E | Human | Esophagus | ESCC | 1.87e-12 | 3.34e-01 | 0.1149 |
149345 | SHISA4 | P30T-E | Human | Esophagus | ESCC | 6.98e-12 | 5.35e-01 | 0.137 |
149345 | SHISA4 | P31T-E | Human | Esophagus | ESCC | 3.65e-09 | 1.91e-01 | 0.1251 |
149345 | SHISA4 | P32T-E | Human | Esophagus | ESCC | 1.01e-15 | 3.97e-01 | 0.1666 |
149345 | SHISA4 | P37T-E | Human | Esophagus | ESCC | 3.63e-09 | 2.23e-01 | 0.1371 |
149345 | SHISA4 | P38T-E | Human | Esophagus | ESCC | 8.31e-05 | 2.11e-01 | 0.127 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SHISA4 | SNV | Missense_Mutation | rs867436400 | c.268N>A | p.Ala90Thr | p.A90T | Q96DD7 | protein_coding | deleterious(0) | possibly_damaging(0.7) | TCGA-D8-A1Y2-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
SHISA4 | deletion | In_Frame_Del | novel | c.168_182delNNNNNNNNNNNNNNN | p.Tyr58_Cys62del | p.Y58_C62del | Q96DD7 | protein_coding | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | ||
SHISA4 | insertion | Frame_Shift_Ins | novel | c.436_437insCA | p.Asp146AlafsTer65 | p.D146Afs*65 | Q96DD7 | protein_coding | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | ||
SHISA4 | insertion | Frame_Shift_Ins | novel | c.438_439insTTTCTGGGGCAGGAGCCTAT | p.Pro147PhefsTer70 | p.P147Ffs*70 | Q96DD7 | protein_coding | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | ||
SHISA4 | SNV | Missense_Mutation | rs367890261 | c.347G>A | p.Arg116His | p.R116H | Q96DD7 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SHISA4 | SNV | Missense_Mutation | novel | c.145T>G | p.Phe49Val | p.F49V | Q96DD7 | protein_coding | tolerated(0.32) | benign(0.007) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SHISA4 | SNV | Missense_Mutation | c.40G>A | p.Ala14Thr | p.A14T | Q96DD7 | protein_coding | tolerated_low_confidence(0.15) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SHISA4 | SNV | Missense_Mutation | novel | c.89A>T | p.Asp30Val | p.D30V | Q96DD7 | protein_coding | deleterious(0) | benign(0.44) | TCGA-AG-3894-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
SHISA4 | SNV | Missense_Mutation | novel | c.370N>A | p.Pro124Thr | p.P124T | Q96DD7 | protein_coding | tolerated(0.08) | benign(0.007) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SHISA4 | SNV | Missense_Mutation | novel | c.569N>T | p.Pro190Leu | p.P190L | Q96DD7 | protein_coding | tolerated(0.74) | benign(0.098) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |