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Gene: RSPH3 |
Gene summary for RSPH3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | RSPH3 | Gene ID | 83861 |
Gene name | radial spoke head 3 | |
Gene Alias | CILD32 | |
Cytomap | 6q25.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q86UC2 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83861 | RSPH3 | LZE4T | Human | Esophagus | ESCC | 2.04e-05 | 9.59e-02 | 0.0811 |
83861 | RSPH3 | LZE7T | Human | Esophagus | ESCC | 6.76e-07 | 3.43e-01 | 0.0667 |
83861 | RSPH3 | LZE8T | Human | Esophagus | ESCC | 7.47e-05 | 1.33e-01 | 0.067 |
83861 | RSPH3 | LZE22T | Human | Esophagus | ESCC | 1.92e-03 | 1.95e-01 | 0.068 |
83861 | RSPH3 | LZE24T | Human | Esophagus | ESCC | 1.32e-05 | 2.99e-01 | 0.0596 |
83861 | RSPH3 | P1T-E | Human | Esophagus | ESCC | 2.09e-03 | 1.28e-01 | 0.0875 |
83861 | RSPH3 | P2T-E | Human | Esophagus | ESCC | 4.70e-17 | 3.02e-01 | 0.1177 |
83861 | RSPH3 | P4T-E | Human | Esophagus | ESCC | 4.22e-13 | 3.19e-01 | 0.1323 |
83861 | RSPH3 | P5T-E | Human | Esophagus | ESCC | 2.86e-08 | 1.28e-01 | 0.1327 |
83861 | RSPH3 | P8T-E | Human | Esophagus | ESCC | 5.47e-18 | 1.93e-01 | 0.0889 |
83861 | RSPH3 | P9T-E | Human | Esophagus | ESCC | 5.24e-04 | 1.65e-01 | 0.1131 |
83861 | RSPH3 | P10T-E | Human | Esophagus | ESCC | 1.91e-24 | 3.54e-01 | 0.116 |
83861 | RSPH3 | P11T-E | Human | Esophagus | ESCC | 2.20e-02 | 2.38e-01 | 0.1426 |
83861 | RSPH3 | P12T-E | Human | Esophagus | ESCC | 4.21e-09 | 1.89e-01 | 0.1122 |
83861 | RSPH3 | P15T-E | Human | Esophagus | ESCC | 1.56e-18 | 3.59e-01 | 0.1149 |
83861 | RSPH3 | P16T-E | Human | Esophagus | ESCC | 1.22e-12 | 3.08e-01 | 0.1153 |
83861 | RSPH3 | P17T-E | Human | Esophagus | ESCC | 1.05e-04 | 1.34e-01 | 0.1278 |
83861 | RSPH3 | P20T-E | Human | Esophagus | ESCC | 4.63e-18 | 2.96e-01 | 0.1124 |
83861 | RSPH3 | P21T-E | Human | Esophagus | ESCC | 1.49e-20 | 2.59e-01 | 0.1617 |
83861 | RSPH3 | P22T-E | Human | Esophagus | ESCC | 8.80e-14 | 1.62e-01 | 0.1236 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RSPH3 | SNV | Missense_Mutation | novel | c.407N>A | p.Arg136Gln | p.R136Q | Q86UC2 | protein_coding | tolerated_low_confidence(0.18) | benign(0.007) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RSPH3 | SNV | Missense_Mutation | c.1151N>G | p.Ile384Arg | p.I384R | Q86UC2 | protein_coding | tolerated(0.44) | benign(0.418) | TCGA-BH-A18T-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
RSPH3 | SNV | Missense_Mutation | novel | c.1118N>C | p.Glu373Ala | p.E373A | Q86UC2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RSPH3 | SNV | Missense_Mutation | rs756201606 | c.1213C>G | p.Leu405Val | p.L405V | Q86UC2 | protein_coding | deleterious(0.02) | probably_damaging(0.957) | TCGA-E2-A14N-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
RSPH3 | SNV | Missense_Mutation | novel | c.781C>T | p.Leu261Phe | p.L261F | Q86UC2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RSPH3 | SNV | Missense_Mutation | novel | c.937G>C | p.Glu313Gln | p.E313Q | Q86UC2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A2LZ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
RSPH3 | SNV | Missense_Mutation | novel | c.407N>T | p.Arg136Leu | p.R136L | Q86UC2 | protein_coding | tolerated_low_confidence(0.05) | benign(0.048) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RSPH3 | SNV | Missense_Mutation | novel | c.457C>T | p.Arg153Trp | p.R153W | Q86UC2 | protein_coding | deleterious(0.02) | possibly_damaging(0.617) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RSPH3 | SNV | Missense_Mutation | novel | c.683G>T | p.Arg228Met | p.R228M | Q86UC2 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
RSPH3 | SNV | Missense_Mutation | c.1172N>T | p.Thr391Ile | p.T391I | Q86UC2 | protein_coding | deleterious(0.02) | possibly_damaging(0.863) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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