GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:000599612 | Liver | Cirrhotic | monosaccharide metabolic process | 104/4634 | 257/18723 | 1.74e-08 | 6.32e-07 | 104 |
GO:001931812 | Liver | Cirrhotic | hexose metabolic process | 97/4634 | 237/18723 | 2.67e-08 | 9.16e-07 | 97 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:000941012 | Liver | Cirrhotic | response to xenobiotic stimulus | 165/4634 | 462/18723 | 6.82e-08 | 2.09e-06 | 165 |
GO:000600611 | Liver | Cirrhotic | glucose metabolic process | 82/4634 | 196/18723 | 1.01e-07 | 2.93e-06 | 82 |
GO:006201212 | Liver | Cirrhotic | regulation of small molecule metabolic process | 124/4634 | 334/18723 | 2.74e-07 | 6.79e-06 | 124 |
GO:000762312 | Liver | Cirrhotic | circadian rhythm | 84/4634 | 210/18723 | 7.04e-07 | 1.50e-05 | 84 |
GO:001921611 | Liver | Cirrhotic | regulation of lipid metabolic process | 119/4634 | 331/18723 | 3.05e-06 | 5.39e-05 | 119 |
GO:00329221 | Liver | Cirrhotic | circadian regulation of gene expression | 34/4634 | 68/18723 | 6.04e-06 | 9.74e-05 | 34 |
GO:000610911 | Liver | Cirrhotic | regulation of carbohydrate metabolic process | 70/4634 | 178/18723 | 1.14e-05 | 1.62e-04 | 70 |
GO:00192181 | Liver | Cirrhotic | regulation of steroid metabolic process | 44/4634 | 100/18723 | 1.97e-05 | 2.62e-04 | 44 |
GO:004851111 | Liver | Cirrhotic | rhythmic process | 103/4634 | 298/18723 | 8.47e-05 | 9.19e-04 | 103 |
GO:00714661 | Liver | Cirrhotic | cellular response to xenobiotic stimulus | 66/4634 | 177/18723 | 1.34e-04 | 1.31e-03 | 66 |
GO:004426211 | Liver | Cirrhotic | cellular carbohydrate metabolic process | 97/4634 | 283/18723 | 1.89e-04 | 1.76e-03 | 97 |
GO:00109061 | Liver | Cirrhotic | regulation of glucose metabolic process | 47/4634 | 119/18723 | 2.61e-04 | 2.33e-03 | 47 |
GO:00106751 | Liver | Cirrhotic | regulation of cellular carbohydrate metabolic process | 54/4634 | 146/18723 | 6.53e-04 | 4.96e-03 | 54 |
GO:000680511 | Liver | Cirrhotic | xenobiotic metabolic process | 43/4634 | 111/18723 | 7.51e-04 | 5.54e-03 | 43 |
GO:00427525 | Liver | Cirrhotic | regulation of circadian rhythm | 45/4634 | 121/18723 | 1.55e-03 | 1.01e-02 | 45 |
GO:0036314 | Liver | Cirrhotic | response to sterol | 17/4634 | 36/18723 | 2.82e-03 | 1.63e-02 | 17 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RORC | SNV | Missense_Mutation | rs368067137 | c.1183G>A | p.Glu395Lys | p.E395K | P51449 | protein_coding | deleterious(0) | benign(0.191) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RORC | SNV | Missense_Mutation | | c.502G>A | p.Glu168Lys | p.E168K | P51449 | protein_coding | tolerated(0.21) | possibly_damaging(0.694) | TCGA-AN-A04D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RORC | SNV | Missense_Mutation | | c.40N>A | p.Glu14Lys | p.E14K | P51449 | protein_coding | tolerated(0.19) | benign(0.015) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
RORC | SNV | Missense_Mutation | novel | c.1483N>A | p.Gln495Lys | p.Q495K | P51449 | protein_coding | tolerated(0.31) | benign(0.084) | TCGA-AR-A1AP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
RORC | SNV | Missense_Mutation | rs866433322 | c.847N>A | p.Glu283Lys | p.E283K | P51449 | protein_coding | deleterious(0) | benign(0.036) | TCGA-BH-A18F-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
RORC | insertion | Nonsense_Mutation | novel | c.867_868insTAAGATTTTAACAGGCATTCATGGGGGTGGGGCAGGCATTCG | p.Leu289_Glu290insTer | p.L289_E290ins* | P51449 | protein_coding | | | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
RORC | SNV | Missense_Mutation | novel | c.427G>A | p.Gly143Arg | p.G143R | P51449 | protein_coding | tolerated(0.37) | benign(0.067) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RORC | SNV | Missense_Mutation | | c.1303N>C | p.Glu435Gln | p.E435Q | P51449 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD |
RORC | SNV | Missense_Mutation | novel | c.313N>T | p.Arg105Cys | p.R105C | P51449 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
RORC | SNV | Missense_Mutation | rs546157871 | c.278N>T | p.Ala93Val | p.A93V | P51449 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | DOMIPHEN BROMIDE | DOMIPHEN BROMIDE | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | ANDROSTENEDIONE | ANDROSTENEDIONE | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | TESTOSTERONE | TESTOSTERONE | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | VTP-43742 | | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | CARMINE | CARMINE | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | agonist | 348353620 | | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | FLUTAMIDE | FLUTAMIDE | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | RHEIN | RHEIN | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | TAK-828 | | |
6097 | RORC | DRUGGABLE GENOME, NUCLEAR HORMONE RECEPTOR, TRANSCRIPTION FACTOR | | BBI-6000 | | |