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Gene: PTPRCAP |
Gene summary for PTPRCAP |
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Gene information | Species | Human | Gene symbol | PTPRCAP | Gene ID | 5790 |
Gene name | protein tyrosine phosphatase receptor type C associated protein | |
Gene Alias | CD45-AP | |
Cytomap | 11q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006950 | UniProtAcc | Q14761 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5790 | PTPRCAP | LZE4T | Human | Esophagus | ESCC | 2.39e-17 | 7.23e-01 | 0.0811 |
5790 | PTPRCAP | LZE7T | Human | Esophagus | ESCC | 1.56e-14 | 8.91e-01 | 0.0667 |
5790 | PTPRCAP | LZE8T | Human | Esophagus | ESCC | 1.35e-07 | 4.98e-01 | 0.067 |
5790 | PTPRCAP | LZE20T | Human | Esophagus | ESCC | 1.26e-02 | 2.92e-01 | 0.0662 |
5790 | PTPRCAP | LZE22D1 | Human | Esophagus | HGIN | 1.24e-04 | 6.34e-01 | 0.0595 |
5790 | PTPRCAP | LZE24T | Human | Esophagus | ESCC | 9.19e-06 | 3.11e-01 | 0.0596 |
5790 | PTPRCAP | LZE6T | Human | Esophagus | ESCC | 3.52e-25 | 1.22e+00 | 0.0845 |
5790 | PTPRCAP | P130T-E | Human | Esophagus | ESCC | 9.53e-09 | 2.58e-01 | 0.1676 |
5790 | PTPRCAP | GSM5353216_PA_PB1A_Pool_1_3_S50_L002 | Human | Prostate | Tumor | 2.22e-03 | 5.63e-01 | 0.159 |
5790 | PTPRCAP | GSM5353218_PA_PB1B_Pool_1_2_S74_L003 | Human | Prostate | Tumor | 7.60e-04 | 4.99e-01 | 0.1479 |
5790 | PTPRCAP | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 4.53e-02 | 1.82e-01 | 0.1633 |
5790 | PTPRCAP | GSM5353226_PA_PR5196-2_Pool_1_2_3_S54_L002 | Human | Prostate | Tumor | 1.14e-06 | 6.36e-01 | 0.159 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRCAP | SNV | Missense_Mutation | novel | c.324N>T | p.Glu108Asp | p.E108D | Q14761 | protein_coding | tolerated(0.05) | benign(0.346) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PTPRCAP | SNV | Missense_Mutation | rs138220100 | c.464C>T | p.Thr155Met | p.T155M | Q14761 | protein_coding | tolerated(0.09) | benign(0.001) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
PTPRCAP | SNV | Missense_Mutation | rs142388162 | c.577N>A | p.Ala193Thr | p.A193T | Q14761 | protein_coding | tolerated(0.19) | benign(0.029) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PTPRCAP | SNV | Missense_Mutation | rs199676581 | c.391G>A | p.Glu131Lys | p.E131K | Q14761 | protein_coding | tolerated(0.23) | benign(0.003) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
PTPRCAP | SNV | Missense_Mutation | c.284N>T | p.Ala95Val | p.A95V | Q14761 | protein_coding | tolerated(0.4) | benign(0.012) | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PTPRCAP | SNV | Missense_Mutation | novel | c.454G>T | p.Asp152Tyr | p.D152Y | Q14761 | protein_coding | deleterious(0.01) | possibly_damaging(0.66) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
PTPRCAP | SNV | Missense_Mutation | novel | c.584C>A | p.Ala195Glu | p.A195E | Q14761 | protein_coding | deleterious(0.01) | possibly_damaging(0.494) | TCGA-50-5931-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PTPRCAP | SNV | Missense_Mutation | c.557N>T | p.Ser186Ile | p.S186I | Q14761 | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-69-8253-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
PTPRCAP | SNV | Missense_Mutation | c.262N>A | p.Gly88Ser | p.G88S | Q14761 | protein_coding | deleterious(0.03) | possibly_damaging(0.66) | TCGA-33-4538-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PTPRCAP | SNV | Missense_Mutation | novel | c.236G>T | p.Arg79Leu | p.R79L | Q14761 | protein_coding | deleterious(0.03) | benign(0.09) | TCGA-56-6546-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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