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Gene: PDIA5 |
Gene summary for PDIA5 |
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Gene information | Species | Human | Gene symbol | PDIA5 | Gene ID | 10954 |
Gene name | protein disulfide isomerase family A member 5 | |
Gene Alias | PDIR | |
Cytomap | 3q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | Q14554 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10954 | PDIA5 | LZE2T | Human | Esophagus | ESCC | 7.47e-07 | 5.31e-01 | 0.082 |
10954 | PDIA5 | LZE4T | Human | Esophagus | ESCC | 7.63e-06 | 1.62e-01 | 0.0811 |
10954 | PDIA5 | LZE7T | Human | Esophagus | ESCC | 2.84e-02 | 2.18e-01 | 0.0667 |
10954 | PDIA5 | LZE24T | Human | Esophagus | ESCC | 4.79e-02 | 1.26e-01 | 0.0596 |
10954 | PDIA5 | P1T-E | Human | Esophagus | ESCC | 2.66e-03 | 1.54e-01 | 0.0875 |
10954 | PDIA5 | P2T-E | Human | Esophagus | ESCC | 8.12e-16 | 2.53e-01 | 0.1177 |
10954 | PDIA5 | P4T-E | Human | Esophagus | ESCC | 6.30e-17 | 3.50e-01 | 0.1323 |
10954 | PDIA5 | P5T-E | Human | Esophagus | ESCC | 6.42e-19 | 4.15e-01 | 0.1327 |
10954 | PDIA5 | P8T-E | Human | Esophagus | ESCC | 1.28e-09 | 2.18e-01 | 0.0889 |
10954 | PDIA5 | P9T-E | Human | Esophagus | ESCC | 2.73e-22 | 5.86e-01 | 0.1131 |
10954 | PDIA5 | P10T-E | Human | Esophagus | ESCC | 9.56e-37 | 6.75e-01 | 0.116 |
10954 | PDIA5 | P11T-E | Human | Esophagus | ESCC | 1.42e-11 | 4.23e-01 | 0.1426 |
10954 | PDIA5 | P12T-E | Human | Esophagus | ESCC | 1.63e-21 | 3.89e-01 | 0.1122 |
10954 | PDIA5 | P15T-E | Human | Esophagus | ESCC | 1.26e-19 | 4.50e-01 | 0.1149 |
10954 | PDIA5 | P16T-E | Human | Esophagus | ESCC | 3.88e-30 | 6.29e-01 | 0.1153 |
10954 | PDIA5 | P17T-E | Human | Esophagus | ESCC | 4.95e-07 | 3.13e-01 | 0.1278 |
10954 | PDIA5 | P19T-E | Human | Esophagus | ESCC | 4.54e-02 | 2.83e-01 | 0.1662 |
10954 | PDIA5 | P20T-E | Human | Esophagus | ESCC | 4.45e-08 | 1.84e-01 | 0.1124 |
10954 | PDIA5 | P21T-E | Human | Esophagus | ESCC | 6.50e-18 | 2.80e-01 | 0.1617 |
10954 | PDIA5 | P22T-E | Human | Esophagus | ESCC | 1.79e-16 | 3.27e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:0022900110 | Esophagus | ESCC | electron transport chain | 133/8552 | 175/18723 | 2.18e-16 | 1.67e-14 | 133 |
GO:00060917 | Liver | NAFLD | generation of precursor metabolites and energy | 84/1882 | 490/18723 | 7.03e-07 | 3.95e-05 | 84 |
GO:00229007 | Liver | NAFLD | electron transport chain | 29/1882 | 175/18723 | 4.87e-03 | 3.84e-02 | 29 |
GO:000609112 | Liver | Cirrhotic | generation of precursor metabolites and energy | 238/4634 | 490/18723 | 6.85e-31 | 1.07e-27 | 238 |
GO:002290012 | Liver | Cirrhotic | electron transport chain | 111/4634 | 175/18723 | 1.94e-27 | 1.52e-24 | 111 |
GO:00064577 | Liver | Cirrhotic | protein folding | 114/4634 | 212/18723 | 9.23e-20 | 2.31e-17 | 114 |
GO:000609122 | Liver | HCC | generation of precursor metabolites and energy | 340/7958 | 490/18723 | 4.04e-34 | 2.85e-31 | 340 |
GO:000645712 | Liver | HCC | protein folding | 160/7958 | 212/18723 | 1.07e-22 | 1.88e-20 | 160 |
GO:002290022 | Liver | HCC | electron transport chain | 134/7958 | 175/18723 | 3.32e-20 | 4.68e-18 | 134 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:002290018 | Oral cavity | OSCC | electron transport chain | 126/7305 | 175/18723 | 6.65e-19 | 8.42e-17 | 126 |
GO:000609118 | Oral cavity | OSCC | generation of precursor metabolites and energy | 286/7305 | 490/18723 | 1.45e-18 | 1.71e-16 | 286 |
GO:000645719 | Oral cavity | LP | protein folding | 125/4623 | 212/18723 | 1.62e-26 | 8.45e-24 | 125 |
GO:002290019 | Oral cavity | LP | electron transport chain | 108/4623 | 175/18723 | 2.21e-25 | 9.90e-23 | 108 |
GO:000609119 | Oral cavity | LP | generation of precursor metabolites and energy | 214/4623 | 490/18723 | 1.12e-20 | 2.60e-18 | 214 |
GO:0006457112 | Thyroid | PTC | protein folding | 137/5968 | 212/18723 | 8.29e-23 | 2.01e-20 | 137 |
GO:0006091112 | Thyroid | PTC | generation of precursor metabolites and energy | 252/5968 | 490/18723 | 8.24e-20 | 1.13e-17 | 252 |
GO:0022900111 | Thyroid | PTC | electron transport chain | 104/5968 | 175/18723 | 4.68e-14 | 2.79e-12 | 104 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDIA5 | SNV | Missense_Mutation | novel | c.1057C>T | p.Pro353Ser | p.P353S | Q14554 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
PDIA5 | SNV | Missense_Mutation | c.68N>T | p.Ser23Phe | p.S23F | Q14554 | protein_coding | deleterious(0.01) | possibly_damaging(0.541) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PDIA5 | SNV | Missense_Mutation | c.1336N>A | p.Asp446Asn | p.D446N | Q14554 | protein_coding | tolerated(0.07) | probably_damaging(0.988) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
PDIA5 | SNV | Missense_Mutation | novel | c.1510N>G | p.Leu504Val | p.L504V | Q14554 | protein_coding | tolerated(0.05) | benign(0.347) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
PDIA5 | SNV | Missense_Mutation | rs544687330 | c.599G>A | p.Arg200Gln | p.R200Q | Q14554 | protein_coding | deleterious(0) | possibly_damaging(0.7) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
PDIA5 | SNV | Missense_Mutation | c.1030G>A | p.Ala344Thr | p.A344T | Q14554 | protein_coding | deleterious(0.01) | benign(0.42) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PDIA5 | SNV | Missense_Mutation | rs774726526 | c.1222C>T | p.Arg408Trp | p.R408W | Q14554 | protein_coding | deleterious(0) | probably_damaging(0.956) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDIA5 | SNV | Missense_Mutation | rs768075468 | c.688A>T | p.Ile230Phe | p.I230F | Q14554 | protein_coding | tolerated(0.49) | benign(0.159) | TCGA-IR-A3LB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
PDIA5 | SNV | Missense_Mutation | rs772836826 | c.673C>T | p.Arg225Cys | p.R225C | Q14554 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PDIA5 | SNV | Missense_Mutation | c.242N>T | p.Cys81Phe | p.C81F | Q14554 | protein_coding | tolerated(0.12) | benign(0.001) | TCGA-AA-A02Y-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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