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Gene: PDIA2 |
Gene summary for PDIA2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PDIA2 | Gene ID | 64714 |
| Gene name | protein disulfide isomerase family A member 2 | |
| Gene Alias | PDA2 | |
| Cytomap | 16p13.3 | |
| Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | Q13087 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 64714 | PDIA2 | HTA12-26-1 | Human | Pancreas | PDAC | 9.84e-03 | -5.31e-01 | 0.3728 |
| 64714 | PDIA2 | HTA12-29-1 | Human | Pancreas | PDAC | 1.59e-13 | -5.31e-01 | 0.3722 |
| 64714 | PDIA2 | HTA12-9-1 | Human | Pancreas | PDAC | 2.00e-05 | -5.31e-01 | 0.1532 |
| 64714 | PDIA2 | 3829-EC | Human | Pancreas | PanIN | 1.54e-10 | 3.78e-01 | 0.009 |
| 64714 | PDIA2 | 4347-EC | Human | Pancreas | PanIN | 4.68e-05 | -2.59e-01 | 0.0572 |
| 64714 | PDIA2 | 4741-EC1 | Human | Pancreas | PanIN | 3.85e-06 | 8.05e-01 | 0.0223 |
| 64714 | PDIA2 | 4741-EC2 | Human | Pancreas | PanIN | 4.17e-13 | 4.97e-01 | 0.0194 |
| 64714 | PDIA2 | DS20191261Tumor | Human | Pancreas | PDAC | 5.26e-07 | -5.31e-01 | 0.1367 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Cervix | N_HPV |  |
| Endometrium | AEH |  |
| Endometrium | EEC |  |
| Prostate | BPH |  |
| Prostate | Tumor |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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