TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
PBX4 | LYMEND | Colorectum | Healthy | FYB1,ABCC3,CDH1, etc. | 6.93e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Colorectum/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PBX4 | QUIE | Esophagus | ADJ | PLA2G16,LDLRAD4,LTB, etc. | 1.26e-01 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PBX4 | PRO | Esophagus | ADJ | PLA2G16,LDLRAD4,LTB, etc. | 7.29e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PBX4 | QUIE | Esophagus | HGIN | PLA2G16,LDLRAD4,LTB, etc. | 8.69e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_HGIN/regulons_activity_in_dotplot.png) |
PBX4 | MYOFIB | Esophagus | ADJ | PPFIBP2,TNFRSF18,CDS1, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PBX4 | INCAF | Esophagus | ADJ | PPFIBP2,TNFRSF18,CDS1, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ADJ/regulons_activity_in_dotplot.png) |
PBX4 | FIB | Esophagus | ESCC | PPFIBP2,TNFRSF18,CDS1, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_ESCC/regulons_activity_in_dotplot.png) |
PBX4 | MYOFIB | Esophagus | Healthy | PPFIBP2,TNFRSF18,CDS1, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Esophagus/Str/TF_Healthy/regulons_activity_in_dotplot.png) |
PBX4 | BAS | Lung | AAH | IL7R,CD6,SYTL3, etc. | 9.56e-02 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AAH/regulons_activity_in_dotplot.png) |
PBX4 | BAS | Lung | AIS | IL7R,CD6,SYTL3, etc. | 0.00e+00 | ![The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.](images/gene_regulatory/Lung/Str/TF_AIS/regulons_activity_in_dotplot.png) |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PBX4 | SNV | Missense_Mutation | novel | c.503C>A | p.Pro168His | p.P168H | Q9BYU1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A25A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Cytoxan | SD |
PBX4 | SNV | Missense_Mutation | rs762057005 | c.614N>T | p.Ser205Leu | p.S205L | Q9BYU1 | protein_coding | deleterious(0) | benign(0.015) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | rs139542458 | c.872C>T | p.Thr291Met | p.T291M | Q9BYU1 | protein_coding | deleterious(0.04) | possibly_damaging(0.761) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | rs199673541 | c.662N>T | p.Ala221Val | p.A221V | Q9BYU1 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PBX4 | SNV | Missense_Mutation | | c.706N>A | p.Pro236Thr | p.P236T | Q9BYU1 | protein_coding | deleterious(0.02) | probably_damaging(0.924) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PBX4 | SNV | Missense_Mutation | rs550438529 | c.287N>T | p.Pro96Leu | p.P96L | Q9BYU1 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AD-A5EK-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | rs766502529 | c.610N>T | p.Arg204Cys | p.R204C | Q9BYU1 | protein_coding | deleterious(0.01) | benign(0.067) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | rs762057005 | c.614C>T | p.Ser205Leu | p.S205L | Q9BYU1 | protein_coding | deleterious(0) | benign(0.015) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | novel | c.166G>A | p.Val56Met | p.V56M | Q9BYU1 | protein_coding | deleterious(0) | possibly_damaging(0.688) | TCGA-AJ-A8CT-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PBX4 | SNV | Missense_Mutation | rs757291376 | c.640N>T | p.Arg214Trp | p.R214W | Q9BYU1 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |