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Gene: PAPD4 |
Gene summary for PAPD4 |
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Gene information | Species | Human | Gene symbol | PAPD4 | Gene ID | 167153 |
Gene name | terminal nucleotidyltransferase 2 | |
Gene Alias | APD4 | |
Cytomap | 5q14.1 | |
Gene Type | protein-coding | GO ID | GO:0000956 | UniProtAcc | Q6PIY7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
167153 | PAPD4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.29e-28 | 5.11e-01 | 0.294 |
167153 | PAPD4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 5.11e-13 | 1.04e+00 | 0.3487 |
167153 | PAPD4 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.80e-21 | 6.80e-01 | 0.281 |
167153 | PAPD4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.29e-28 | 5.97e-01 | 0.3859 |
167153 | PAPD4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.79e-04 | 2.27e-01 | 0.2585 |
167153 | PAPD4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.73e-12 | 2.44e-01 | 0.3005 |
167153 | PAPD4 | P1T-E | Human | Esophagus | ESCC | 3.10e-03 | 9.26e-02 | 0.0875 |
167153 | PAPD4 | P2T-E | Human | Esophagus | ESCC | 1.09e-17 | 3.38e-01 | 0.1177 |
167153 | PAPD4 | P4T-E | Human | Esophagus | ESCC | 1.35e-14 | 2.45e-01 | 0.1323 |
167153 | PAPD4 | P5T-E | Human | Esophagus | ESCC | 1.16e-11 | 1.10e-01 | 0.1327 |
167153 | PAPD4 | P8T-E | Human | Esophagus | ESCC | 1.38e-13 | 2.22e-01 | 0.0889 |
167153 | PAPD4 | P9T-E | Human | Esophagus | ESCC | 3.58e-10 | 1.73e-01 | 0.1131 |
167153 | PAPD4 | P10T-E | Human | Esophagus | ESCC | 1.01e-18 | 2.52e-01 | 0.116 |
167153 | PAPD4 | P11T-E | Human | Esophagus | ESCC | 1.30e-12 | 2.72e-01 | 0.1426 |
167153 | PAPD4 | P12T-E | Human | Esophagus | ESCC | 1.01e-19 | 3.44e-01 | 0.1122 |
167153 | PAPD4 | P15T-E | Human | Esophagus | ESCC | 6.04e-21 | 3.23e-01 | 0.1149 |
167153 | PAPD4 | P16T-E | Human | Esophagus | ESCC | 5.84e-21 | 2.35e-01 | 0.1153 |
167153 | PAPD4 | P17T-E | Human | Esophagus | ESCC | 8.99e-04 | 1.70e-01 | 0.1278 |
167153 | PAPD4 | P20T-E | Human | Esophagus | ESCC | 1.06e-16 | 3.83e-01 | 0.1124 |
167153 | PAPD4 | P21T-E | Human | Esophagus | ESCC | 8.24e-12 | 2.33e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAPD4 | SNV | Missense_Mutation | c.1209N>G | p.Asp403Glu | p.D403E | Q6PIY7 | protein_coding | tolerated(0.06) | possibly_damaging(0.522) | TCGA-BH-A1EX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PAPD4 | SNV | Missense_Mutation | c.275N>A | p.Arg92His | p.R92H | Q6PIY7 | protein_coding | deleterious(0.03) | benign(0.058) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
PAPD4 | SNV | Missense_Mutation | rs759971099 | c.1234N>T | p.Arg412Cys | p.R412C | Q6PIY7 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
PAPD4 | SNV | Missense_Mutation | rs759269207 | c.973N>T | p.Arg325Cys | p.R325C | Q6PIY7 | protein_coding | deleterious(0) | benign(0.125) | TCGA-A6-2679-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAPD4 | SNV | Missense_Mutation | c.542N>A | p.Arg181Gln | p.R181Q | Q6PIY7 | protein_coding | deleterious(0.02) | possibly_damaging(0.555) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PAPD4 | SNV | Missense_Mutation | c.542N>A | p.Arg181Gln | p.R181Q | Q6PIY7 | protein_coding | deleterious(0.02) | possibly_damaging(0.555) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PAPD4 | SNV | Missense_Mutation | rs549225169 | c.1339G>A | p.Glu447Lys | p.E447K | Q6PIY7 | protein_coding | deleterious(0.01) | benign(0.081) | TCGA-CM-6168-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAPD4 | SNV | Missense_Mutation | c.1239N>T | p.Glu413Asp | p.E413D | Q6PIY7 | protein_coding | tolerated(0.17) | benign(0.18) | TCGA-CM-6171-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAPD4 | SNV | Missense_Mutation | c.268C>T | p.Arg90Trp | p.R90W | Q6PIY7 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PAPD4 | SNV | Missense_Mutation | c.238G>A | p.Asp80Asn | p.D80N | Q6PIY7 | protein_coding | tolerated(0.45) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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