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Gene: NUDT22 |
Gene summary for NUDT22 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NUDT22 | Gene ID | 84304 |
Gene name | nudix hydrolase 22 | |
Gene Alias | NUDT22 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BRQ3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84304 | NUDT22 | LZE2T | Human | Esophagus | ESCC | 3.32e-02 | 5.83e-01 | 0.082 |
84304 | NUDT22 | LZE4T | Human | Esophagus | ESCC | 2.02e-12 | 4.29e-01 | 0.0811 |
84304 | NUDT22 | LZE7T | Human | Esophagus | ESCC | 3.68e-09 | 4.37e-01 | 0.0667 |
84304 | NUDT22 | LZE8T | Human | Esophagus | ESCC | 2.30e-13 | 4.20e-01 | 0.067 |
84304 | NUDT22 | LZE20T | Human | Esophagus | ESCC | 8.46e-07 | 2.92e-01 | 0.0662 |
84304 | NUDT22 | LZE22D1 | Human | Esophagus | HGIN | 3.96e-03 | 2.74e-01 | 0.0595 |
84304 | NUDT22 | LZE22T | Human | Esophagus | ESCC | 1.03e-05 | 3.96e-01 | 0.068 |
84304 | NUDT22 | LZE24T | Human | Esophagus | ESCC | 3.29e-30 | 8.74e-01 | 0.0596 |
84304 | NUDT22 | LZE6T | Human | Esophagus | ESCC | 9.11e-16 | 4.72e-01 | 0.0845 |
84304 | NUDT22 | P1T-E | Human | Esophagus | ESCC | 1.18e-20 | 7.44e-01 | 0.0875 |
84304 | NUDT22 | P2T-E | Human | Esophagus | ESCC | 9.28e-26 | 4.87e-01 | 0.1177 |
84304 | NUDT22 | P4T-E | Human | Esophagus | ESCC | 2.74e-49 | 1.23e+00 | 0.1323 |
84304 | NUDT22 | P5T-E | Human | Esophagus | ESCC | 1.00e-28 | 6.11e-01 | 0.1327 |
84304 | NUDT22 | P8T-E | Human | Esophagus | ESCC | 1.98e-28 | 5.76e-01 | 0.0889 |
84304 | NUDT22 | P9T-E | Human | Esophagus | ESCC | 3.95e-27 | 6.23e-01 | 0.1131 |
84304 | NUDT22 | P10T-E | Human | Esophagus | ESCC | 1.59e-15 | 3.64e-01 | 0.116 |
84304 | NUDT22 | P11T-E | Human | Esophagus | ESCC | 1.95e-17 | 6.36e-01 | 0.1426 |
84304 | NUDT22 | P12T-E | Human | Esophagus | ESCC | 2.32e-36 | 7.41e-01 | 0.1122 |
84304 | NUDT22 | P15T-E | Human | Esophagus | ESCC | 3.62e-15 | 3.11e-01 | 0.1149 |
84304 | NUDT22 | P16T-E | Human | Esophagus | ESCC | 3.41e-16 | 3.82e-01 | 0.1153 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NUDT22 | SNV | Missense_Mutation | novel | c.763G>A | p.Glu255Lys | p.E255K | Q9BRQ3 | protein_coding | tolerated(0.47) | benign(0.021) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
NUDT22 | SNV | Missense_Mutation | c.316N>T | p.Gly106Cys | p.G106C | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | novel | c.152N>T | p.Ala51Val | p.A51V | Q9BRQ3 | protein_coding | tolerated(0.15) | benign(0.076) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | novel | c.187N>A | p.Leu63Met | p.L63M | Q9BRQ3 | protein_coding | deleterious(0.04) | probably_damaging(0.928) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | rs763178803 | c.175N>T | p.Pro59Ser | p.P59S | Q9BRQ3 | protein_coding | tolerated(0.66) | benign(0.005) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | rs764713316 | c.730N>A | p.Glu244Lys | p.E244K | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A2K7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD |
NUDT22 | SNV | Missense_Mutation | novel | c.98N>A | p.Pro33Gln | p.P33Q | Q9BRQ3 | protein_coding | tolerated(0.22) | benign(0.281) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NUDT22 | SNV | Missense_Mutation | c.775G>A | p.Val259Met | p.V259M | Q9BRQ3 | protein_coding | tolerated(0.27) | benign(0.095) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | c.602N>C | p.Leu201Pro | p.L201P | Q9BRQ3 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A11U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NUDT22 | SNV | Missense_Mutation | novel | c.732N>T | p.Glu244Asp | p.E244D | Q9BRQ3 | protein_coding | deleterious(0) | possibly_damaging(0.755) | TCGA-B5-A11Y-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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