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Gene: NPIPB3 |
Gene summary for NPIPB3 |
Gene summary. |
Gene information | Species | Human | Gene symbol | NPIPB3 | Gene ID | 23117 |
Gene name | nuclear pore complex interacting protein family member B3 | |
Gene Alias | KIAA0220L | |
Cytomap | 16p12.2 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23117 | NPIPB3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.63e-36 | 8.28e-01 | 0.0155 |
23117 | NPIPB3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.34e-39 | 1.20e+00 | -0.1808 |
23117 | NPIPB3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.66e-20 | 1.39e+00 | 0.0216 |
23117 | NPIPB3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.13e-49 | 1.51e+00 | -0.0811 |
23117 | NPIPB3 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.07e-42 | 1.24e+00 | -0.1088 |
23117 | NPIPB3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.04e-93 | 1.98e+00 | -0.1954 |
23117 | NPIPB3 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.78e-17 | 1.34e+00 | -0.2602 |
23117 | NPIPB3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.13e-12 | 1.18e+00 | -0.2196 |
23117 | NPIPB3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.96e-33 | 1.06e+00 | -0.1207 |
23117 | NPIPB3 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.11e-26 | 1.01e+00 | -0.1526 |
23117 | NPIPB3 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.01e-77 | 1.43e+00 | -0.1464 |
23117 | NPIPB3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.05e-99 | 1.69e+00 | -0.1001 |
23117 | NPIPB3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.85e-58 | 1.64e+00 | -0.059 |
23117 | NPIPB3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.39e-13 | 1.00e+00 | -0.1706 |
23117 | NPIPB3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.41e-11 | 8.27e-01 | -0.2061 |
23117 | NPIPB3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 2.68e-15 | 1.04e+00 | -0.1462 |
23117 | NPIPB3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.28e-32 | 1.42e+00 | -0.0842 |
23117 | NPIPB3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.18e-10 | 1.05e+00 | -0.00410000000000005 |
23117 | NPIPB3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.29e-12 | 7.98e-01 | -0.0179 |
23117 | NPIPB3 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.07e-28 | 8.36e-01 | 0.096 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NPIPB3 | SNV | Missense_Mutation | rs371811840 | c.382N>A | p.Glu128Lys | p.E128K | Q92617 | protein_coding | tolerated(0.11) | probably_damaging(0.956) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NPIPB3 | SNV | Missense_Mutation | novel | c.445A>C | p.Asn149His | p.N149H | Q92617 | protein_coding | tolerated(0.11) | probably_damaging(0.994) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
NPIPB3 | SNV | Missense_Mutation | novel | c.431C>A | p.Pro144His | p.P144H | Q92617 | protein_coding | tolerated(0.2) | probably_damaging(0.996) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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