![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MRPS33 |
Gene summary for MRPS33 |
![]() |
Gene information | Species | Human | Gene symbol | MRPS33 | Gene ID | 51650 |
Gene name | mitochondrial ribosomal protein S33 | |
Gene Alias | CGI-139 | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | A4D1T3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51650 | MRPS33 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.00e-05 | 2.12e-01 | 0.0155 |
51650 | MRPS33 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.08e-06 | 3.53e-01 | -0.0811 |
51650 | MRPS33 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.40e-18 | 5.14e-01 | -0.1954 |
51650 | MRPS33 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.79e-08 | 6.63e-01 | -0.1526 |
51650 | MRPS33 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.76e-07 | 3.72e-01 | -0.1464 |
51650 | MRPS33 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.81e-08 | 4.89e-01 | -0.059 |
51650 | MRPS33 | HTA11_2992_2000001011 | Human | Colorectum | SER | 4.93e-05 | 6.06e-01 | -0.1706 |
51650 | MRPS33 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.93e-03 | 4.07e-01 | -0.2061 |
51650 | MRPS33 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.94e-06 | 5.44e-01 | -0.1462 |
51650 | MRPS33 | HTA11_546_2000001011 | Human | Colorectum | AD | 2.02e-03 | 3.21e-01 | -0.0842 |
51650 | MRPS33 | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.46e-04 | 5.05e-01 | -0.0179 |
51650 | MRPS33 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.13e-09 | 4.15e-01 | 0.096 |
51650 | MRPS33 | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.16e-05 | 5.22e-01 | 0.0446 |
51650 | MRPS33 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.04e-03 | 4.36e-01 | 0.0528 |
51650 | MRPS33 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.30e-04 | 4.56e-01 | 0.0131 |
51650 | MRPS33 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.26e-07 | 6.29e-01 | 0.0171 |
51650 | MRPS33 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.57e-09 | 4.38e-01 | 0.0674 |
51650 | MRPS33 | HTA11_7469_2000001011 | Human | Colorectum | AD | 8.15e-07 | 7.81e-01 | -0.0124 |
51650 | MRPS33 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.06e-19 | 6.34e-01 | 0.294 |
51650 | MRPS33 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.02e-02 | 8.56e-01 | 0.3487 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS33 | SNV | Missense_Mutation | c.302N>C | p.Arg101Thr | p.R101T | Q9Y291 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS33 | SNV | Missense_Mutation | rs779139791 | c.50N>A | p.Arg17Gln | p.R17Q | Q9Y291 | protein_coding | tolerated(0.12) | benign(0.173) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
MRPS33 | deletion | Frame_Shift_Del | c.301delA | p.Arg101GlufsTer55 | p.R101Efs*55 | Q9Y291 | protein_coding | TCGA-G4-6302-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MRPS33 | SNV | Missense_Mutation | novel | c.71G>T | p.Arg24Met | p.R24M | Q9Y291 | protein_coding | deleterious(0.03) | probably_damaging(0.945) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS33 | SNV | Missense_Mutation | c.280N>T | p.Pro94Ser | p.P94S | Q9Y291 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-BS-A0TJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MRPS33 | deletion | Frame_Shift_Del | c.301delN | p.Arg101GlufsTer55 | p.R101Efs*55 | Q9Y291 | protein_coding | TCGA-D1-A17M-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |||
MRPS33 | deletion | Frame_Shift_Del | novel | c.223delN | p.His75IlefsTer11 | p.H75Ifs*11 | Q9Y291 | protein_coding | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPS33 | deletion | Frame_Shift_Del | novel | c.313delA | p.Arg105GlyfsTer51 | p.R105Gfs*51 | Q9Y291 | protein_coding | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPS33 | SNV | Missense_Mutation | c.203N>C | p.Leu68Pro | p.L68P | Q9Y291 | protein_coding | deleterious(0.01) | possibly_damaging(0.892) | TCGA-DD-A1EK-01 | Liver | liver hepatocellular carcinoma | Female | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
MRPS33 | SNV | Missense_Mutation | rs750148841 | c.304N>T | p.Ala102Ser | p.A102S | Q9Y291 | protein_coding | tolerated(0.33) | benign(0.033) | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |