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Gene: MRPL27 |
Gene summary for MRPL27 |
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Gene information | Species | Human | Gene symbol | MRPL27 | Gene ID | 51264 |
Gene name | mitochondrial ribosomal protein L27 | |
Gene Alias | L27mt | |
Cytomap | 17q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9P0M9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51264 | MRPL27 | GSM4909290 | Human | Breast | IDC | 4.02e-20 | 6.23e-01 | 0.2096 |
51264 | MRPL27 | GSM4909291 | Human | Breast | IDC | 3.46e-53 | 1.08e+00 | 0.1753 |
51264 | MRPL27 | GSM4909296 | Human | Breast | IDC | 6.34e-06 | -2.12e-02 | 0.1524 |
51264 | MRPL27 | GSM4909297 | Human | Breast | IDC | 1.70e-09 | 3.06e-02 | 0.1517 |
51264 | MRPL27 | GSM4909301 | Human | Breast | IDC | 3.01e-02 | 1.99e-01 | 0.1577 |
51264 | MRPL27 | GSM4909307 | Human | Breast | IDC | 2.64e-05 | 3.31e-01 | 0.1569 |
51264 | MRPL27 | GSM4909308 | Human | Breast | IDC | 3.22e-07 | 3.60e-01 | 0.158 |
51264 | MRPL27 | GSM4909311 | Human | Breast | IDC | 5.52e-20 | -1.61e-01 | 0.1534 |
51264 | MRPL27 | GSM4909312 | Human | Breast | IDC | 1.12e-08 | 1.20e-03 | 0.1552 |
51264 | MRPL27 | GSM4909316 | Human | Breast | IDC | 3.68e-07 | 3.80e-01 | 0.21 |
51264 | MRPL27 | GSM4909318 | Human | Breast | IDC | 1.42e-04 | 3.15e-01 | 0.2031 |
51264 | MRPL27 | GSM4909319 | Human | Breast | IDC | 1.76e-31 | 9.02e-02 | 0.1563 |
51264 | MRPL27 | GSM4909320 | Human | Breast | IDC | 3.58e-07 | 4.63e-02 | 0.1575 |
51264 | MRPL27 | GSM4909321 | Human | Breast | IDC | 1.46e-11 | 1.15e-01 | 0.1559 |
51264 | MRPL27 | brca1 | Human | Breast | Precancer | 1.61e-12 | 4.57e-01 | -0.0338 |
51264 | MRPL27 | brca2 | Human | Breast | Precancer | 9.86e-05 | 3.21e-01 | -0.024 |
51264 | MRPL27 | brca3 | Human | Breast | Precancer | 6.01e-10 | 3.21e-01 | -0.0263 |
51264 | MRPL27 | M1 | Human | Breast | IDC | 6.49e-08 | 4.47e-01 | 0.1577 |
51264 | MRPL27 | NCCBC14 | Human | Breast | DCIS | 1.14e-13 | 4.27e-01 | 0.2021 |
51264 | MRPL27 | NCCBC5 | Human | Breast | DCIS | 1.71e-05 | -3.64e-04 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa0301039 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010115 | Esophagus | HGIN | Ribosome | 108/1383 | 167/8465 | 1.44e-45 | 4.71e-43 | 3.74e-43 | 108 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPL27 | SNV | Missense_Mutation | novel | c.58N>T | p.Pro20Ser | p.P20S | Q9P0M9 | protein_coding | tolerated(0.09) | benign(0) | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPL27 | insertion | Nonsense_Mutation | novel | c.55_56insAATATGGTTAAAAACTGTATATACAACACAGTTTAATCTCTCT | p.Ser19LysfsTer4 | p.S19Kfs*4 | Q9P0M9 | protein_coding | TCGA-A8-A06Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
MRPL27 | SNV | Missense_Mutation | c.384G>T | p.Lys128Asn | p.K128N | Q9P0M9 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
MRPL27 | SNV | Missense_Mutation | rs768545678 | c.148C>T | p.Arg50Cys | p.R50C | Q9P0M9 | protein_coding | tolerated(0.13) | benign(0.053) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MRPL27 | SNV | Missense_Mutation | c.356N>A | p.Arg119Lys | p.R119K | Q9P0M9 | protein_coding | tolerated(0.61) | benign(0) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPL27 | SNV | Missense_Mutation | c.43A>G | p.Thr15Ala | p.T15A | Q9P0M9 | protein_coding | tolerated(0.75) | benign(0.015) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
MRPL27 | SNV | Missense_Mutation | rs763878672 | c.221N>A | p.Arg74His | p.R74H | Q9P0M9 | protein_coding | deleterious(0.01) | benign(0.157) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | rs750648679 | c.212N>A | p.Arg71His | p.R71H | Q9P0M9 | protein_coding | tolerated(0.07) | possibly_damaging(0.896) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | novel | c.307N>A | p.Val103Ile | p.V103I | Q9P0M9 | protein_coding | tolerated(0.1) | probably_damaging(0.999) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPL27 | SNV | Missense_Mutation | novel | c.287N>C | p.Ile96Thr | p.I96T | Q9P0M9 | protein_coding | tolerated(0.41) | benign(0.007) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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