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Gene: LINC01456 |
Gene summary for LINC01456 |
Gene summary. |
Gene information | Species | Human | Gene symbol | LINC01456 | Gene ID | 105373144 |
Gene name | long intergenic non-protein coding RNA 1456 | |
Gene Alias | LINC01456 | |
Cytomap | Xp22.13 | |
Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
105373144 | LINC01456 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.07e-81 | 1.27e+00 | 0.0155 |
105373144 | LINC01456 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.86e-48 | 1.15e+00 | -0.1808 |
105373144 | LINC01456 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.36e-24 | 9.58e-01 | 0.0216 |
105373144 | LINC01456 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.28e-66 | 1.76e+00 | -0.0811 |
105373144 | LINC01456 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.85e-15 | 3.78e-01 | -0.1088 |
105373144 | LINC01456 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.56e-54 | 9.57e-01 | -0.1954 |
105373144 | LINC01456 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.63e-25 | 1.40e+00 | -0.2602 |
105373144 | LINC01456 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.09e-30 | 1.50e+00 | -0.2196 |
105373144 | LINC01456 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.86e-53 | 1.35e+00 | -0.1207 |
105373144 | LINC01456 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.85e-50 | 1.49e+00 | -0.1526 |
105373144 | LINC01456 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.96e-133 | 2.01e+00 | -0.1464 |
105373144 | LINC01456 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.02e-61 | 1.04e+00 | -0.1001 |
105373144 | LINC01456 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.09e-68 | 1.43e+00 | -0.059 |
105373144 | LINC01456 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.75e-38 | 1.48e+00 | -0.1706 |
105373144 | LINC01456 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.92e-43 | 1.57e+00 | -0.2061 |
105373144 | LINC01456 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.37e-37 | 2.05e+00 | -0.1462 |
105373144 | LINC01456 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.74e-35 | 9.75e-01 | -0.0842 |
105373144 | LINC01456 | HTA11_9341_2000001011 | Human | Colorectum | SER | 1.86e-06 | 3.96e-01 | -0.00410000000000005 |
105373144 | LINC01456 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.04e-16 | 5.05e-01 | -0.0179 |
105373144 | LINC01456 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.64e-19 | 4.13e-01 | 0.096 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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