|
Gene: KLF12 |
Gene summary for KLF12 |
Gene summary. |
Gene information | Species | Human | Gene symbol | KLF12 | Gene ID | 11278 |
Gene name | Kruppel like factor 12 | |
Gene Alias | AP-2rep | |
Cytomap | 13q22.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q8WWI3 |
Top |
Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11278 | KLF12 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.96e-06 | -4.10e-01 | 0.0155 |
11278 | KLF12 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.46e-02 | -2.80e-01 | -0.1464 |
11278 | KLF12 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.99e-07 | -4.71e-01 | 0.096 |
11278 | KLF12 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.25e-03 | -1.84e-01 | 0.294 |
11278 | KLF12 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.94e-05 | -4.11e-01 | 0.3859 |
11278 | KLF12 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.91e-05 | -5.81e-01 | 0.2585 |
11278 | KLF12 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.01e-07 | -3.73e-01 | 0.3005 |
11278 | KLF12 | A015-C-203 | Human | Colorectum | FAP | 7.32e-15 | -3.26e-01 | -0.1294 |
11278 | KLF12 | A015-C-204 | Human | Colorectum | FAP | 2.26e-02 | -2.41e-01 | -0.0228 |
11278 | KLF12 | A014-C-040 | Human | Colorectum | FAP | 2.49e-02 | -4.18e-01 | -0.1184 |
11278 | KLF12 | A002-C-201 | Human | Colorectum | FAP | 1.23e-10 | -3.88e-01 | 0.0324 |
11278 | KLF12 | A001-C-108 | Human | Colorectum | FAP | 1.45e-05 | -2.37e-01 | -0.0272 |
11278 | KLF12 | A002-C-205 | Human | Colorectum | FAP | 1.13e-15 | -4.54e-01 | -0.1236 |
11278 | KLF12 | A015-C-005 | Human | Colorectum | FAP | 1.50e-02 | -2.76e-01 | -0.0336 |
11278 | KLF12 | A015-C-006 | Human | Colorectum | FAP | 3.30e-12 | -5.33e-01 | -0.0994 |
11278 | KLF12 | A015-C-106 | Human | Colorectum | FAP | 1.34e-04 | -1.82e-01 | -0.0511 |
11278 | KLF12 | A002-C-114 | Human | Colorectum | FAP | 6.53e-12 | -4.20e-01 | -0.1561 |
11278 | KLF12 | A015-C-104 | Human | Colorectum | FAP | 8.34e-18 | -4.34e-01 | -0.1899 |
11278 | KLF12 | A001-C-014 | Human | Colorectum | FAP | 6.80e-05 | -2.24e-01 | 0.0135 |
11278 | KLF12 | A002-C-016 | Human | Colorectum | FAP | 1.26e-12 | -3.22e-01 | 0.0521 |
Page: 1 2 3 4 |
Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | |
Endometrium | AEH | |
Endometrium | EEC | |
Prostate | BPH | |
Prostate | Tumor |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 2 3 4 |
Top |
Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF12 | SNV | Missense_Mutation | novel | c.1054N>A | p.Glu352Lys | p.E352K | Q9Y4X4 | protein_coding | deleterious(0.01) | benign(0.048) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KLF12 | SNV | Missense_Mutation | rs762948057 | c.44C>T | p.Thr15Ile | p.T15I | Q9Y4X4 | protein_coding | tolerated_low_confidence(0.19) | benign(0) | TCGA-AN-A04A-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.964G>C | p.Glu322Gln | p.E322Q | Q9Y4X4 | protein_coding | deleterious(0.05) | possibly_damaging(0.607) | TCGA-BH-A28O-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |
KLF12 | insertion | Frame_Shift_Ins | novel | c.907_908insCGGTAAAACATGGCTCACAGCAAGCAAGTCCAGTCCA | p.Gln303ProfsTer17 | p.Q303Pfs*17 | Q9Y4X4 | protein_coding | TCGA-A8-A06P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | SD | |||
KLF12 | SNV | Missense_Mutation | rs375091947 | c.634N>A | p.Val212Met | p.V212M | Q9Y4X4 | protein_coding | deleterious(0.03) | benign(0.178) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | novel | c.452N>T | p.Ser151Phe | p.S151F | Q9Y4X4 | protein_coding | deleterious(0) | possibly_damaging(0.462) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF12 | SNV | Missense_Mutation | c.1156N>G | p.Phe386Val | p.F386V | Q9Y4X4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF12 | SNV | Missense_Mutation | novel | c.389N>C | p.Ile130Thr | p.I130T | Q9Y4X4 | protein_coding | tolerated(0.22) | possibly_damaging(0.84) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
KLF12 | SNV | Missense_Mutation | c.250N>G | p.Leu84Val | p.L84V | Q9Y4X4 | protein_coding | deleterious(0) | possibly_damaging(0.899) | TCGA-AA-3842-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | PD | |
KLF12 | SNV | Missense_Mutation | novel | c.1075N>A | p.Ala359Thr | p.A359T | Q9Y4X4 | protein_coding | deleterious(0.02) | benign(0.221) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |