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Gene: KIAA0391 |
Gene summary for KIAA0391 |
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Gene information | Species | Human | Gene symbol | KIAA0391 | Gene ID | 9692 |
Gene name | protein only RNase P catalytic subunit | |
Gene Alias | KIAA0391 | |
Cytomap | 14q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000959 | UniProtAcc | O15091 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9692 | KIAA0391 | P1T-E | Human | Esophagus | ESCC | 7.11e-04 | 1.99e-01 | 0.0875 |
9692 | KIAA0391 | P2T-E | Human | Esophagus | ESCC | 1.21e-14 | 2.59e-01 | 0.1177 |
9692 | KIAA0391 | P4T-E | Human | Esophagus | ESCC | 1.06e-14 | 3.47e-01 | 0.1323 |
9692 | KIAA0391 | P5T-E | Human | Esophagus | ESCC | 1.37e-12 | 1.83e-01 | 0.1327 |
9692 | KIAA0391 | P8T-E | Human | Esophagus | ESCC | 2.16e-31 | 5.07e-01 | 0.0889 |
9692 | KIAA0391 | P9T-E | Human | Esophagus | ESCC | 8.38e-03 | 9.64e-02 | 0.1131 |
9692 | KIAA0391 | P10T-E | Human | Esophagus | ESCC | 2.12e-15 | 2.17e-01 | 0.116 |
9692 | KIAA0391 | P11T-E | Human | Esophagus | ESCC | 4.74e-03 | 1.58e-01 | 0.1426 |
9692 | KIAA0391 | P12T-E | Human | Esophagus | ESCC | 3.88e-60 | 1.06e+00 | 0.1122 |
9692 | KIAA0391 | P15T-E | Human | Esophagus | ESCC | 6.21e-15 | 2.85e-01 | 0.1149 |
9692 | KIAA0391 | P16T-E | Human | Esophagus | ESCC | 4.43e-05 | 7.26e-02 | 0.1153 |
9692 | KIAA0391 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 3.09e-01 | 0.1662 |
9692 | KIAA0391 | P20T-E | Human | Esophagus | ESCC | 2.16e-09 | 2.34e-01 | 0.1124 |
9692 | KIAA0391 | P21T-E | Human | Esophagus | ESCC | 4.36e-14 | 2.28e-01 | 0.1617 |
9692 | KIAA0391 | P22T-E | Human | Esophagus | ESCC | 1.42e-08 | 1.27e-01 | 0.1236 |
9692 | KIAA0391 | P23T-E | Human | Esophagus | ESCC | 4.05e-21 | 5.55e-01 | 0.108 |
9692 | KIAA0391 | P24T-E | Human | Esophagus | ESCC | 1.51e-08 | 1.77e-01 | 0.1287 |
9692 | KIAA0391 | P26T-E | Human | Esophagus | ESCC | 3.70e-17 | 2.58e-01 | 0.1276 |
9692 | KIAA0391 | P27T-E | Human | Esophagus | ESCC | 1.25e-26 | 4.49e-01 | 0.1055 |
9692 | KIAA0391 | P28T-E | Human | Esophagus | ESCC | 2.04e-11 | 1.85e-01 | 0.1149 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0391 | SNV | Missense_Mutation | c.1176N>C | p.Lys392Asn | p.K392N | O15091 | protein_coding | tolerated(0.13) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA0391 | SNV | Missense_Mutation | novel | c.1070C>T | p.Ser357Phe | p.S357F | O15091 | protein_coding | deleterious(0) | possibly_damaging(0.9) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0391 | SNV | Missense_Mutation | c.1681G>A | p.Asp561Asn | p.D561N | O15091 | protein_coding | deleterious(0.01) | probably_damaging(0.992) | TCGA-BH-A18U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
KIAA0391 | insertion | Nonsense_Mutation | novel | c.890_891insG | p.Tyr297Ter | p.Y297* | O15091 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0391 | insertion | Frame_Shift_Ins | novel | c.891_892insGGCACAATCTCGGGCTCACTGCAAGCTCCGCCTC | p.Ser298GlyfsTer14 | p.S298Gfs*14 | O15091 | protein_coding | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIAA0391 | SNV | Missense_Mutation | novel | c.526N>A | p.Asp176Asn | p.D176N | O15091 | protein_coding | tolerated(1) | benign(0) | TCGA-ZJ-AAXJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KIAA0391 | SNV | Missense_Mutation | novel | c.316N>A | p.Ala106Thr | p.A106T | O15091 | protein_coding | tolerated(0.92) | benign(0.022) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
KIAA0391 | SNV | Missense_Mutation | novel | c.107G>C | p.Arg36Pro | p.R36P | O15091 | protein_coding | tolerated_low_confidence(0.2) | benign(0) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
KIAA0391 | SNV | Missense_Mutation | c.1214N>T | p.Asp405Val | p.D405V | O15091 | protein_coding | deleterious(0.02) | probably_damaging(0.987) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0391 | SNV | Missense_Mutation | c.668N>T | p.Ser223Leu | p.S223L | O15091 | protein_coding | deleterious(0) | benign(0.444) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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