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Gene: INO80C |
Gene summary for INO80C |
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Gene information | Species | Human | Gene symbol | INO80C | Gene ID | 125476 |
Gene name | INO80 complex subunit C | |
Gene Alias | C18orf37 | |
Cytomap | 18q12.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q6PI98 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
125476 | INO80C | LZE4T | Human | Esophagus | ESCC | 1.10e-05 | 2.23e-01 | 0.0811 |
125476 | INO80C | LZE7T | Human | Esophagus | ESCC | 6.92e-10 | 6.77e-01 | 0.0667 |
125476 | INO80C | LZE8T | Human | Esophagus | ESCC | 3.30e-02 | 4.78e-02 | 0.067 |
125476 | INO80C | LZE24T | Human | Esophagus | ESCC | 5.13e-07 | 1.41e-01 | 0.0596 |
125476 | INO80C | P1T-E | Human | Esophagus | ESCC | 1.94e-03 | 3.13e-01 | 0.0875 |
125476 | INO80C | P2T-E | Human | Esophagus | ESCC | 1.50e-18 | 3.57e-01 | 0.1177 |
125476 | INO80C | P4T-E | Human | Esophagus | ESCC | 1.87e-19 | 6.20e-01 | 0.1323 |
125476 | INO80C | P5T-E | Human | Esophagus | ESCC | 4.31e-17 | 2.35e-01 | 0.1327 |
125476 | INO80C | P8T-E | Human | Esophagus | ESCC | 1.16e-14 | 3.05e-01 | 0.0889 |
125476 | INO80C | P9T-E | Human | Esophagus | ESCC | 2.41e-38 | 1.01e+00 | 0.1131 |
125476 | INO80C | P10T-E | Human | Esophagus | ESCC | 1.16e-11 | 2.63e-01 | 0.116 |
125476 | INO80C | P11T-E | Human | Esophagus | ESCC | 1.01e-06 | 3.93e-01 | 0.1426 |
125476 | INO80C | P12T-E | Human | Esophagus | ESCC | 2.37e-24 | 5.28e-01 | 0.1122 |
125476 | INO80C | P15T-E | Human | Esophagus | ESCC | 3.07e-15 | 3.44e-01 | 0.1149 |
125476 | INO80C | P16T-E | Human | Esophagus | ESCC | 7.83e-12 | 1.21e-01 | 0.1153 |
125476 | INO80C | P17T-E | Human | Esophagus | ESCC | 1.88e-06 | 4.50e-01 | 0.1278 |
125476 | INO80C | P19T-E | Human | Esophagus | ESCC | 2.04e-03 | 7.05e-01 | 0.1662 |
125476 | INO80C | P20T-E | Human | Esophagus | ESCC | 8.49e-24 | 5.41e-01 | 0.1124 |
125476 | INO80C | P21T-E | Human | Esophagus | ESCC | 1.30e-26 | 5.48e-01 | 0.1617 |
125476 | INO80C | P22T-E | Human | Esophagus | ESCC | 1.65e-20 | 3.01e-01 | 0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000632517 | Esophagus | ESCC | chromatin organization | 240/8552 | 409/18723 | 6.52e-08 | 1.14e-06 | 240 |
GO:00063101 | Esophagus | ESCC | DNA recombination | 168/8552 | 305/18723 | 5.58e-04 | 3.05e-03 | 168 |
GO:000632511 | Liver | HCC | chromatin organization | 206/7958 | 409/18723 | 7.23e-04 | 4.41e-03 | 206 |
GO:0006310 | Oral cavity | OSCC | DNA recombination | 147/7305 | 305/18723 | 6.33e-04 | 3.56e-03 | 147 |
GO:000632510 | Oral cavity | OSCC | chromatin organization | 190/7305 | 409/18723 | 1.17e-03 | 5.97e-03 | 190 |
GO:000632519 | Skin | cSCC | chromatin organization | 147/4864 | 409/18723 | 4.41e-06 | 6.52e-05 | 147 |
GO:000633812 | Skin | cSCC | chromatin remodeling | 94/4864 | 255/18723 | 7.58e-05 | 7.26e-04 | 94 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INO80C | SNV | Missense_Mutation | c.106N>T | p.Gly36Cys | p.G36C | Q6PI98 | protein_coding | deleterious_low_confidence(0) | benign(0.258) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INO80C | SNV | Missense_Mutation | c.683N>T | p.Pro228Leu | p.P228L | Q6PI98 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.617) | TCGA-D8-A1XV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
INO80C | SNV | Missense_Mutation | c.477N>G | p.Asn159Lys | p.N159K | Q6PI98 | protein_coding | deleterious(0.01) | benign(0.194) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
INO80C | SNV | Missense_Mutation | rs768152671 | c.82N>C | p.Ser28Pro | p.S28P | Q6PI98 | protein_coding | deleterious_low_confidence(0) | benign(0.26) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
INO80C | SNV | Missense_Mutation | novel | c.277N>A | p.Glu93Lys | p.E93K | Q6PI98 | protein_coding | deleterious(0.01) | benign(0.081) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
INO80C | SNV | Missense_Mutation | c.671N>T | p.Thr224Met | p.T224M | Q6PI98 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-CI-6622-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD | |
INO80C | SNV | Missense_Mutation | c.369C>A | p.Asn123Lys | p.N123K | Q6PI98 | protein_coding | tolerated(0.08) | benign(0.366) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD | |
INO80C | SNV | Missense_Mutation | novel | c.659N>C | p.Leu220Pro | p.L220P | Q6PI98 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
INO80C | SNV | Missense_Mutation | novel | c.392N>T | p.Gly131Val | p.G131V | Q6PI98 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-B5-A5OC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
INO80C | SNV | Missense_Mutation | rs376287863 | c.619N>T | p.Arg207Trp | p.R207W | Q6PI98 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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