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Gene: HYLS1 |
Gene summary for HYLS1 |
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Gene information | Species | Human | Gene symbol | HYLS1 | Gene ID | 219844 |
Gene name | HYLS1 centriolar and ciliogenesis associated | |
Gene Alias | HLS | |
Cytomap | 11q24.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A0A024R3K0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
219844 | HYLS1 | HCC1_Meng | Human | Liver | HCC | 8.56e-27 | 3.77e-02 | 0.0246 |
219844 | HYLS1 | HCC1 | Human | Liver | HCC | 5.88e-05 | 1.47e+00 | 0.5336 |
219844 | HYLS1 | HCC2 | Human | Liver | HCC | 2.14e-16 | 1.77e+00 | 0.5341 |
219844 | HYLS1 | HCC5 | Human | Liver | HCC | 3.45e-05 | 7.38e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Cervix | N_HPV | ![]() |
Endometrium | AEH | ![]() |
Endometrium | EEC | ![]() |
Prostate | BPH | ![]() |
Prostate | Tumor | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HYLS1 | SNV | Missense_Mutation | c.664G>A | p.Asp222Asn | p.D222N | Q96M11 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A2-A0EV-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HYLS1 | SNV | Missense_Mutation | c.627N>C | p.Lys209Asn | p.K209N | Q96M11 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HYLS1 | SNV | Missense_Mutation | novel | c.786N>G | p.Asn262Lys | p.N262K | Q96M11 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-LL-A8F5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
HYLS1 | SNV | Missense_Mutation | rs772908693 | c.377A>G | p.Gln126Arg | p.Q126R | Q96M11 | protein_coding | tolerated(0.53) | benign(0.043) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
HYLS1 | SNV | Missense_Mutation | c.295N>A | p.Leu99Met | p.L99M | Q96M11 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HYLS1 | SNV | Missense_Mutation | rs192439596 | c.589N>T | p.Leu197Phe | p.L197F | Q96M11 | protein_coding | tolerated(0.16) | probably_damaging(0.974) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
HYLS1 | SNV | Missense_Mutation | novel | c.76N>T | p.Ala26Ser | p.A26S | Q96M11 | protein_coding | tolerated(0.1) | benign(0.355) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
HYLS1 | SNV | Missense_Mutation | novel | c.705N>T | p.Lys235Asn | p.K235N | Q96M11 | protein_coding | deleterious(0.01) | probably_damaging(0.983) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HYLS1 | insertion | Frame_Shift_Ins | novel | c.316dupG | p.Glu106GlyfsTer7 | p.E106Gfs*7 | Q96M11 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
HYLS1 | SNV | Missense_Mutation | novel | c.437N>A | p.Ser146Tyr | p.S146Y | Q96M11 | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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